Islet allograft rejection in nonobese diabetic mice involves the common γ-chain and CD28/CD154-dependent and-independent mechanisms

Journal of Immunology

Volumn 171, Issue 7, 2003, Pages 3878-3885

  Demirci, Gulcin ^a   Strom, Terry B ^a   Li, Xian Chang ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD40 LIGAND; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 9; INTERLEUKIN 9 RECEPTOR; UNCLASSIFIED DRUG;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; LYMPHOCYTE ACTIVATION; MEMORY CELL; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0141886132     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3878     Document Type: Article

References (36)

1. Castano, L., and G. S. Eisenbarth. 1990. Type 1 diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8:647.
2. Ryu, S., S. Kodama, K. Ryu, D. A. Schoenfeld, and D. L. Faustman. 2001. Reversal of established autoimmune diabetes by restoration of endogenous β cell function. J. Clin. Invest. 108:63.
3. Rossini, A. A., J. P. Mordes, D. L. Greiner, and J. S. Stoff. Islet cell transplantation tolerance. Transplantation 72:S43, 2001.
4. Santamaria, P. 2001. Effector lymphocytes in autoimmunity. Curr. Opin. Immunol. 13:663.
5. Markees, T., D. Serreze, N. Phillips, C. Sorli, E. Gordon, L. Shultz, R. Noelle, B. Woda, D. Greiner, J. Mordes, et al. 1999. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes 48:967.
6. Kukreja, A., G. Cost, J. Marker, C. Zhang, Z. Sun, K. Lin-Su, S. Ten, M. Sanz, M. Exley, B. Wilson, et al. 2002. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109:131.
7. Pearson, T., T. G. Markees, D. V. Serreze, M. A. Pierce, M. P. Marron, L. S. Wicker, L. B. Peterson, L. D. Shultz, J. P. Mordes, A. A. Rossini, et al 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J. Immunol. 171:185.
8. Janeway, C. A., and K. Bottomly. 1994. Signals and signs for lymphocyte responses, Cell 76:275.
9. Lenschow, D. I., T. L. Walunas, and I. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
10. Li, X. C., and T. B. Strom. 2003. T cell growth factors and the allograft response. Curr. Opin. Organ Transplant. 8:19.
11. Sagamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo, M. Nakamura, and T. Takeshita. 1996. The interleukin-2 receptor γ chain: its role in multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14:179.
12. Asao, H., C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura. 2001. Cutting edge: the common γ-chain is an indispensable sub-unit of the IL-21 receptor complex. J. Immunol. 167:1.
13. Larsen, C. P., and T. C. Pearson. 1997. The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr. Opin. Immunol. 9:641.
14. Kim, Y. S., W. Maslinski, X. X. Zheng, A. C. Stevens, X. C. Li, G. H. Tesch, V. R. Kelley, and T. B. Strom. 1998. Targeting the IL-15 receptor with an antagonist IL- 15 mutant/Fc protein blocks delayed-type hypersensitivity. J. Immunol. 161:5742.
15. Steurer, W., P. W. Nickerson, A. W. Steele, J. Steiger, X. X. Zheng, and T. B. Strom. 1995. Ex vivo coating of islet cell allografts with murine CTLA-4/Fc promotes graft tolerance. J. Immunol. 155:1165.
16. He, Y. W., B. Adkins, R. K. Furse, and T. R. Malek. 1995. Expression and function of the γ subunit of the IL-2, IL-4, and IL-7 receptors. J. Immunol. 154:1596.
17. Li, X. C., A. Ima, Y. Li, X. X. Zheng, T. R. Malek, and T. B. Strom. 2000. Blocking the common γ chain of cytokine receptors induces T cell apoptosis and long term islet allograft survival. J. Immunol. 164:1193.
18. Gallichan, W. S., B. Balasa, J. D. Davies, and N. Sarvetnick. 1999. Pancreatic expression of IL-4 results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. J. Immunol. 163:1696.
19. Li, X. C., P. Roy-Chaadhury, W. W. Hancock, R. C. Manfro, M. S. Zand, Y. Li, X. X. Zheng, J. Steiger, P. W. Nickerson, T. R. Malek, et al. 1998. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J. Immunol. 161:890.
20. Sprent, J., and C. D. Surh. 2001. Generation and maintenance of memory T cells. Curr. Opin. Immunol. 13:248.
21. Bradley, L. M., M. Croft, and S. L. Swaim. 1993. T-cell memory: new perspectives. Immunol. Today 14:197.
22. Makhlouf, L., K. Kishimoto, R. N. Smith, R. Abdi, M. Koulmanda, H. J. Winn, H. Auchincloss, Jr. and M. H. Sayegh. 2002. The role of autoimmunity in islet allograft destruction. Diabetes 51:3202.
23. Li, X. C., Y. Li, I. Dodge, A. D. Wells, X. X. Zheng, L. A. Turka, and T. B. Strom. 1999. Induction of allograft tolerance in the absence of Fas-mediated apoptosis. J. Immunol. 163:2500.
24. Lenschow, D., S. Ho, H. Sattar, L. Rhee, G. Gray, N. Nabavi, K. Herold, and J. Bluestone. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145.
25. Balasa, B., T. Krahl, G. Patstone, J. Lee, R. Tisch, H. McDevitt, and N. Sarvetnick. 1997. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J. Immunol. 159:4620.
26. Demirci, G., W. Gao, X. X. Zheng, T. R. Malek, T. B. Strom, and X. C. Li. 2002. On CD28/CD40 ligand costimulation, common γ-chain signals, and the alloimmune response. J. Immunol. 168:4382.
27. Cao, X., E. W. Shores, J. Hu-Li, M. R. Anver, B. L. Kelsall, S. M. Russell, J. Drago, M. Noguchi, A. Grinberg, and E. T. Bloom. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2:223.
28. + T cells can trigger allograft rejection. J. Immunol. 165:1111.
29. + T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104:1715.
30. Li, X. C., and T. B. Strom. 2000. Blocking T cell costimulation in transplantation: opportunities and challenges. Transfusion 40:139.
31. Yamada, A., A. D. Salama, and M. H. Sayegh. 2002. The role of novel T cell costimulatory pathways in autoimmunity and transplantation. J. Am. Soc. Nephrol. 13:559.
32. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
33. Naumov, Y. N., K. S. Bahjat, R. Gausling, R. Abraham, M. A. Exley, Y. Koezuka, S. B. Balk, J. L. Strominger, M. Clare-Salzer, and S. B. Wilson. 2001. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 98:13838.
34. Okazaki, T., Y. Iwai, and T. Honjo. 2002. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14:779.
35. Bluestone, J. A. 1997. Is CTLA-4 a master switch for peripheral T cell tolerance?. J. Immunol. 158:1989.
36. Luhder, F., C. Chambers, J. P. Allison, C. Benoist, and D. Mathis. 2000. Pin-pointing when T cell costimulaotry receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc. Natl. Acad. Sci. USA 97:12204.