A chemokine-driven positive feedback loop organizes lymphoid follicles

Nature

Volumn 406, Issue 6793, 2000, Pages 309-314

  Ansel, K Mark ^a   Ngo, Vu N ^a   Hyman, Paul L ^a   Luther, Sanjlv A ^a   Förster, Relnhold ^b   Sedgwlck, Jonathon D ^c   Browning, Jeffrey L ^d   Upp, Martin ^b   Cyster, Jason G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c MERCK RESEARCH LABORATORIES   (United States)

^d BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; LYMPHOTOXIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DENDRITIC CELL; FEEDBACK SYSTEM; GENE EXPRESSION; GERMINAL CENTER; LYMPH FOLLICLE; LYMPH NODE; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SPLEEN;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES, CXC; DENDRITIC CELLS; FEEDBACK; FEMALE; LYMPH NODES; LYMPHOTOXIN-ALPHA; MALE; MICE; PEYER'S PATCHES; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE;

ANIMALIA;

EID: 0034691531     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35018581     Document Type: Article

References (30)

1. Förster, R. et al. A putative chemokine receptor, BLR1, directs B-cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87, 1037-1047 (1996).
2. Gunn, M. D. et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391, 799-803 (1998).
3. Legler, D. F. et al. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187, 655-660 (1998).
4. Fu, Y. -X. & Chaplin, D. D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
5. Ngo, V. N. et al. Lymphotoxin-α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412 (1999).
6. Tew, J. G. et al. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156, 39-52 (1997).
7. Fu, Y. X., Huang, G., Wang, Y. & Chaplin, D. D. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J. Exp. Med. 187, 1009-1018 (1998).
8. Gonzalez, M., Mackay, F., Browning, J. L., Kosco-Vilbois, M. H. & Noelle, R. J. The sequential role of lymphotoxin and B cells in the development of splenic follicles. J. Exp. Med. 187, 997-1007 (1998).
9. Endres, R. et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J. Exp. Med. 189, 159-168 (1999).
10. Browning, J. L. et al. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72, 847-856 (1993).
11. Worm, M. & Geha, R. S. CD40 ligation induces lymphotoxin alpha gene expression in human B cells. Int. Immunol. 6, 1883-1890 (1994).
12. Pokholok, D. K. et al. Cloning and expression analysis of the murine lymphotoxin beta gene. Proc. Natl Acad. Sci. USA 92, 674-678 (1995).
13. Browning, J. L. et al. Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes. J. Immunol. 159, 3288-3298 (1997).
14. Miller, J. J. D., Johnsen, D. O. & Ada, G. L. Differences in localization of Salmonella flagella in lymph node follicles of germ-free and conventional rats. Nature 217, 1059-1061 (1968).
15. Mason, D. Y., Jones, M. & Goodnow, C. C. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4, 163-175 (1992).
16. Gutman, G. A. & Weissman, I. L. Homing properties of thymus-independent follicular lymphocytes. Transplantation 16, 621-629 (1973).
17. Kawabe, T. et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1, 167-178 (1994).
18. Vajdy, M., Kosco-Vilbois, M. H., Kopf, M., Kohler, G. & Lycke, N. Impaired mucosal immune responses in interleukin 4-targeted mice. J. Exp. Med. 181, 41-53 (1995).
19. Cyster, J. G. Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102 (1999).
20. Voigt, I. et al. CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone. Eur. J. Immunol. 30, 560-567 (2000).
21. Mackay, F. & Browning, J. L. Turning off follicular dendritic cells. Nature 395, 26-27 (1998).
22. Golovkina, T. V., Shlomchik, M., Hannum, L. & Chervonsky, A. Organogenic role of B lymphocytes in mucosal immunity. Science 286, 1965-1968 (1999).
23. Luther, S. A., Lopez, T., Bai, W., Hanahan, D. & Cyster, J. G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12, 471-481 (2000).
24. Yokota, Y. et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397, 702-706 (1999).
25. + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493-504 (1997).
26. - cells in the embryonic intestine induces the organizing center of Peyer's patches. Int. Immunol. 11, 643-655 (1999).
27. Matsumoto, M. et al. RoIe of lymphotoxin and the type 1 TNF receptor in the formation of germinal centers. Science 271, 1289-1291 (1996).
28. Korner, H. et al. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol. 27, 2600-2609 (1997).
29. Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G. & Cyster, J. G. In vivo activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190, 1123-1134 (1999).
30. Tilney, N. L. Patterns of lymphatic drainage in the adult laboratory rat. J. Anat. 109, 369-383 (1971).