메뉴 건너뛰기




Volumn 53, Issue 7, 2004, Pages 1035-1043

The CD40/CD40L costimulatory pathway in inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

EID: 3042614161     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.026278     Document Type: Review
Times cited : (129)

References (53)
  • 1
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115:182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 2
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 4
    • 0037308263 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology 2003;124:521-36.
    • (2003) Gastroenterology , vol.124 , pp. 521-536
    • Bonen, D.K.1    Cho, J.H.2
  • 5
    • 0036107919 scopus 로고    scopus 로고
    • Immunoregulation in the gut: Success and failures in human disease
    • Monteleone I, Vavassori P, Biancone L, et al. Immunoregulation in the gut: success and failures in human disease. Gut 2002;50(suppl III):iii60-4.
    • (2002) Gut , vol.50 , Issue.3 SUPPL.
    • Monteleone, I.1    Vavassori, P.2    Biancone, L.3
  • 7
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 on cell-mediated immunity
    • Grewal IS, Flavell RA. CD40 and CD154 on cell-mediated immunity. Annu Rev Immunol 1998;16:111-35.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 9
    • 0035129767 scopus 로고    scopus 로고
    • The CD40/CD154 receptor/ligand dyad
    • Schonbeck U, Libby P. The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 2001;58:4-43.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 4-43
    • Schonbeck, U.1    Libby, P.2
  • 10
    • 0345059235 scopus 로고    scopus 로고
    • Targeting of costimulatory molecules as a therpeutic approach in inflammatory bowel disease
    • Maerten P, Liu Z, Ceuppens JL. Targeting of costimulatory molecules as a therpeutic approach in inflammatory bowel disease. Biodrugs 2003;17:395-411.
    • (2003) Biodrugs , vol.17 , pp. 395-411
    • Maerten, P.1    Liu, Z.2    Ceuppens, J.L.3
  • 11
    • 0026535399 scopus 로고
    • Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help)
    • Lederman S, Yellin MJ, Krichevsky A, et al. Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help). J Exp Med 1992;175:1091-101.
    • (1992) J Exp Med , vol.175 , pp. 1091-1101
    • Lederman, S.1    Yellin, M.J.2    Krichevsky, A.3
  • 12
    • 0028353492 scopus 로고
    • The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
    • Smith CA, Farrah T, Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 1994;76:956-62.
    • (1994) Cell , vol.76 , pp. 956-962
    • Smith, C.A.1    Farrah, T.2    Goodwin, R.G.3
  • 13
    • 0029915835 scopus 로고    scopus 로고
    • Human native soluble CD40L is a biologically activer trimer, processed inside microsomes
    • Pietravalle F, Lecoanet-Henchoz S, Blasey H, et al. Human native soluble CD40L is a biologically activer trimer, processed inside microsomes. J Biol Chem 1996;271:5965-7.
    • (1996) J Biol Chem , vol.271 , pp. 5965-5967
    • Pietravalle, F.1    Lecoanet-Henchoz, S.2    Blasey, H.3
  • 14
    • 0033753644 scopus 로고    scopus 로고
    • CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms
    • Grammer AC, Lipsky PE. CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms. Adv Immunol 2001;76:61-178.
    • (2001) Adv Immunol , vol.76 , pp. 61-178
    • Grammer, A.C.1    Lipsky, P.E.2
  • 15
    • 0032534070 scopus 로고    scopus 로고
    • CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: Evidence for TGF-beta but not IL-10-dependnet direct S mu→S alpha and sequential S mu→S gamma, S gamma→A alpha DNA recombination
    • Zan H, Cerutti A, Dramitinos P, et al. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependnet direct S mu→S alpha and sequential S mu→S gamma, S gamma→A alpha DNA recombination. J Immunol 1998;161:5217-25.
    • (1998) J Immunol , vol.161 , pp. 5217-5225
    • Zan, H.1    Cerutti, A.2    Dramitinos, P.3
  • 16
    • 0027504649 scopus 로고
    • CD40 ligand and its role in X-linked hyper-IgM syndrome
    • Callard RE, Armitage RJ, Fanslow WC, et al. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol Today 1993;14:559-64.
    • (1993) Immunol Today , vol.14 , pp. 559-564
    • Callard, R.E.1    Armitage, R.J.2    Fanslow, W.C.3
  • 17
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu J, Foy TM, Laman JD, et al. Mice deficient for the CD40 ligand. Immunity 1994;1:423-31.
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1    Foy, T.M.2    Laman, J.D.3
  • 18
    • 0028806723 scopus 로고    scopus 로고
    • Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
    • Grewal IS, Xu J, Flavell RA. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 1998;378:617-20.
    • (1998) Nature , vol.378 , pp. 617-620
    • Grewal, I.S.1    Xu, J.2    Flavell, R.A.3
  • 19
    • 0028033310 scopus 로고
    • Activation of human dendritic cells through CD40 cross-linking
    • Caux C, Massacrier C, Vanbervliet B, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994;180:1263-72.
    • (1994) J Exp Med , vol.180 , pp. 1263-1272
    • Caux, C.1    Massacrier, C.2    Vanbervliet, B.3
  • 20
    • 0028935411 scopus 로고
    • Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses
    • Roy M, Aruffo A, Ledbetter J, et al. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol 1995;25:596-603.
    • (1995) Eur J Immunol , vol.25 , pp. 596-603
    • Roy, M.1    Aruffo, A.2    Ledbetter, J.3
  • 21
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhnaces T cell stimulatory capacity T-T help via APC activation
    • Cella M, Scheidegger D, Palmer-Lehman K, et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhnaces T cell stimulatory capacity T-T help via APC activation. J Exp Med 1996;184:747-52.
    • (1996) J Exp Med , vol.184 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehman, K.3
  • 22
    • 0034695882 scopus 로고    scopus 로고
    • CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis
    • Blair PJ, Riley JL, Harlan DM, et al. CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000;191:651-60.
    • (2000) J Exp Med , vol.191 , pp. 651-660
    • Blair, P.J.1    Riley, J.L.2    Harlan, D.M.3
  • 24
    • 0029033142 scopus 로고
    • Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation
    • Yellin MJ, Winikoff S, Fortune SM, et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J Leukoc Biol 1995;58:209-16.
    • (1995) J Leukoc Biol , vol.58 , pp. 209-216
    • Yellin, M.J.1    Winikoff, S.2    Fortune, S.M.3
  • 25
    • 0029073133 scopus 로고
    • CD40 on human endothelial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression
    • Karmann K, Hughes CCH, Schechner J, et al. CD40 on human endothelial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995;92:4342-6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4342-4346
    • Karmann, K.1    Hughes, C.C.H.2    Schechner, J.3
  • 26
    • 0031297249 scopus 로고    scopus 로고
    • CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells
    • Dechanet J, Grosset C, Taupin J-L, et al. CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells. J Immunol 1997;159:5640-7.
    • (1997) J Immunol , vol.159 , pp. 5640-5647
    • Dechanet, J.1    Grosset, C.2    Taupin, J.-L.3
  • 27
    • 0344699318 scopus 로고    scopus 로고
    • T lymphocytes induce endothelial cell matrix metalloprofeinase expression by a CD40L-dependent mechanism
    • Mach F, Schonbeck U, Fabunmi RP, et al. T lymphocytes induce endothelial cell matrix metalloprofeinase expression by a CD40L-dependent mechanism. Am J Pathol 1999;154:229-38.
    • (1999) Am J Pathol , vol.154 , pp. 229-238
    • Mach, F.1    Schonbeck, U.2    Fabunmi, R.P.3
  • 28
    • 0033375952 scopus 로고    scopus 로고
    • CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocyte subsets
    • Thienel U, Loike J, Yellin MJ. CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocyte subsets. Cell Immunol 1999;198:87-95.
    • (1999) Cell Immunol , vol.198 , pp. 87-95
    • Thienel, U.1    Loike, J.2    Yellin, M.J.3
  • 29
    • 0031993721 scopus 로고    scopus 로고
    • CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts
    • Zhang Y, Cao HJ, Graf B, et al. CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts. J Immunol 1998;160:1053-7.
    • (1998) J Immunol , vol.160 , pp. 1053-1057
    • Zhang, Y.1    Cao, H.J.2    Graf, B.3
  • 30
    • 0037877918 scopus 로고    scopus 로고
    • CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
    • Inwald DP, McDowall A, Peters MJ, et al. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res 2003;92:944-6.
    • (2003) Circ Res , vol.92 , pp. 944-946
    • Inwald, D.P.1    McDowall, A.2    Peters, M.J.3
  • 31
    • 0842321794 scopus 로고    scopus 로고
    • T-cells trigger CD40-dependent platelet activation and granular RANTES release: A novel pathway for immune response amplification
    • Danese S, de la Motte C, Rivera-Reyes BM, et al. T-cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification. J Immunol 2004;172:2011-15.
    • (2004) J Immunol , vol.172 , pp. 2011-2015
    • Danese, S.1    De La Motte, C.2    Rivera-Reyes, B.M.3
  • 32
    • 0034548824 scopus 로고    scopus 로고
    • Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo
    • Melter M, Reinders MEJ, Sho M, et al. Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. Blood 2000;96:3801-8.
    • (2000) Blood , vol.96 , pp. 3801-3808
    • Melter, M.1    Reinders, M.E.J.2    Sho, M.3
  • 33
    • 0034657793 scopus 로고    scopus 로고
    • CD40 engagement on synovial fibroblasts up-regulates production of vascular endothelial growth factor
    • Cho C-S, Cho M-L, Min S-Y, et al. CD40 engagement on synovial fibroblasts up-regulates production of vascular endothelial growth factor. J Immunol 2000;164:5055-61.
    • (2000) J Immunol , vol.164 , pp. 5055-5061
    • Cho, C.-S.1    Cho, M.-L.2    Min, S.-Y.3
  • 34
    • 0032748465 scopus 로고    scopus 로고
    • Expression of CD40 and its ligand, CD40L, in intestinal lesions or Crohn's disease
    • Battaglia E, Biancone L, Resegotti A, et al. Expression of CD40 and its ligand, CD40L, in intestinal lesions or Crohn's disease. Am J Gastroenterol 1999;94:3279-84.
    • (1999) Am J Gastroenterol , vol.94 , pp. 3279-3284
    • Battaglia, E.1    Biancone, L.2    Resegotti, A.3
  • 35
    • 0036201566 scopus 로고    scopus 로고
    • The role of CD40 in ulcerative colitis: Histochemical analysis and clinical correlation
    • Polese L, Angriman I, Cecchetto A, et al. The role of CD40 in ulcerative colitis: histochemical analysis and clinical correlation. Eur J Gastroenterol Hepatol 2002;14:237-41.
    • (2002) Eur J Gastroenterol Hepatol , vol.14 , pp. 237-241
    • Polese, L.1    Angriman, I.2    Cecchetto, A.3
  • 36
    • 0141534417 scopus 로고    scopus 로고
    • Inducible CD40 expression mediates NFB activation and cytokine secretion in human colonic fibroblasts
    • Gelbmann CM, Leeb SN, Vogel D, et al. Inducible CD40 expression mediates NFB activation and cytokine secretion in human colonic fibroblasts. Gut 2003;52:1448-56.
    • (2003) Gut , vol.52 , pp. 1448-1456
    • Gelbmann, C.M.1    Leeb, S.N.2    Vogel, D.3
  • 37
    • 0346100583 scopus 로고    scopus 로고
    • CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines causing T-cell transmigration
    • Vogel JD, West GA, Sturm A, et al. CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines causing T-cell transmigration. Gastroenterology 2004;126:63-80.
    • (2004) Gastroenterology , vol.126 , pp. 63-80
    • Vogel, J.D.1    West, G.A.2    Sturm, A.3
  • 38
    • 0033214529 scopus 로고    scopus 로고
    • Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production
    • Liu Z, Colpaert S, D'Haens GR, et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J Immunol 1999;163:4049-57.
    • (1999) J Immunol , vol.163 , pp. 4049-4057
    • Liu, Z.1    Colpaert, S.2    D'Haens, G.R.3
  • 39
    • 0038297520 scopus 로고    scopus 로고
    • Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
    • Danese S, de la Motte C, Sturm A, et al. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 2003;124:1249-64.
    • (2003) Gastroenterology , vol.124 , pp. 1249-1264
    • Danese, S.1    De La Motte, C.2    Sturm, A.3
  • 40
    • 0141534421 scopus 로고    scopus 로고
    • Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients
    • Danese S, Katz JA, Saibeni S, et al. Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients. Gut 2003;52:1435-41.
    • (2003) Gut , vol.52 , pp. 1435-1441
    • Danese, S.1    Katz, J.A.2    Saibeni, S.3
  • 41
    • 20244374221 scopus 로고    scopus 로고
    • An increased number of CD40-high monocytes in patients with Crohn's disease
    • Sawada-Hase N, Kiyohara T, Miyagawa J, et al. An increased number of CD40-high monocytes in patients with Crohn's disease. Am J Gastroenterol 2000;95:1516-23.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1516-1523
    • Sawada-Hase, N.1    Kiyohara, T.2    Miyagawa, J.3
  • 42
    • 0038390440 scopus 로고    scopus 로고
    • Plasma levels of soluble CD40 ligand are elevated in inflammatory bowel diseases
    • Ludwiczek O, Kaser A, Tilg H. Plasma levels of soluble CD40 ligand are elevated in inflammatory bowel diseases. Int J Colorectal Dis 2003;18:142-7.
    • (2003) Int J Colorectal Dis , vol.18 , pp. 142-147
    • Ludwiczek, O.1    Kaser, A.2    Tilg, H.3
  • 43
    • 25344468220 scopus 로고    scopus 로고
    • Collagen synthesis by human intestinal fibroblasts (HIF) is modulated by T-cells through the CD40/CD40 ligand (CD40L) pathway
    • Vogel JD, Majors A, Sturm A, et al. Collagen synthesis by human intestinal fibroblasts (HIF) is modulated by T-cells through the CD40/CD40 ligand (CD40L) pathway. Gastroenterology 2001;120:A135.
    • (2001) Gastroenterology , vol.120
    • Vogel, J.D.1    Majors, A.2    Sturm, A.3
  • 44
    • 0142105503 scopus 로고    scopus 로고
    • Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
    • Monk NJ, Hargreaves REG, Marsh JE, et al. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med 2003;9:1275-80.
    • (2003) Nat Med , vol.9 , pp. 1275-1280
    • Monk, N.J.1    Hargreaves, R.E.G.2    Marsh, J.E.3
  • 45
    • 0030029222 scopus 로고    scopus 로고
    • Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of helper T helper 1 cells through the inhibition of interleukin 12 secretion
    • Stuber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of helper T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996;183:693-8.
    • (1996) J Exp Med , vol.183 , pp. 693-698
    • Stuber, E.1    Strober, W.2    Neurath, M.3
  • 46
    • 0034040020 scopus 로고    scopus 로고
    • high CD4+ T cells by blocking the CD40-CD154 interactions
    • high CD4+ T cells by blocking the CD40-CD154 interactions. J Immunol 2000;164:6005-14.
    • (2000) J Immunol , vol.164 , pp. 6005-6014
    • Liu, Z.1    Geboes, K.2    Colpaert, S.3
  • 47
    • 0033865073 scopus 로고    scopus 로고
    • Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration
    • de Jong Y, Comiskey M, Kalled SL, et al. Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology 2000;119:715-23.
    • (2000) Gastroenterology , vol.119 , pp. 715-723
    • De Jong, Y.1    Comiskey, M.2    Kalled, S.L.3
  • 48
    • 0034663766 scopus 로고    scopus 로고
    • Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12
    • Cong BY, Weaver CT, Lazenby A, et al. Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J Immunol 2000;165:2173-82.
    • (2000) J Immunol , vol.165 , pp. 2173-2182
    • Cong, B.Y.1    Weaver, C.T.2    Lazenby, A.3
  • 49
    • 0036177912 scopus 로고    scopus 로고
    • CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice
    • Li W, Buzoni-Gatel D, Debbobi H, et al. CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice. Gastroenterology 2002;122:762-73.
    • (2002) Gastroenterology , vol.122 , pp. 762-773
    • Li, W.1    Buzoni-Gatel, D.2    Debbobi, H.3
  • 51
    • 0036899589 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo controlled trial
    • Kalunian KC, Davis JC, Merrill JT, et al. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo controlled trial. Arthritis Rheum 2002;46:3251-8.
    • (2002) Arthritis Rheum , vol.46 , pp. 3251-3258
    • Kalunian, K.C.1    Davis, J.C.2    Merrill, J.T.3
  • 52
    • 0345824714 scopus 로고    scopus 로고
    • Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    • Grammer AC, Slota R, Fischer R, et al. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J Clin Invest 2003;112:1506-20.
    • (2003) J Clin Invest , vol.112 , pp. 1506-1520
    • Grammer, A.C.1    Slota, R.2    Fischer, R.3
  • 53
    • 0347357810 scopus 로고    scopus 로고
    • Therapeutic CD154 antibody for lupus: Promise for the future?
    • Kelsoe G. Therapeutic CD154 antibody for lupus: promise for the future? J Clin Invest 2003;112:1480-2.
    • (2003) J Clin Invest , vol.112 , pp. 1480-1482
    • Kelsoe, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.