메뉴 건너뛰기




Volumn 19, Issue 3, 2007, Pages 275-280

Affinity of antigen encounter and other early B-cell signals determine B-cell fate

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR;

EID: 34247583988     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2007.04.009     Document Type: Review
Times cited : (59)

References (46)
  • 1
    • 0022353594 scopus 로고
    • Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
    • Vitetta E.S., Ohara J., Myers C.D., Layton J.E., Krammer P.H., and Paul W.E. Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med 162 (1985) 1726-1731
    • (1985) J Exp Med , vol.162 , pp. 1726-1731
    • Vitetta, E.S.1    Ohara, J.2    Myers, C.D.3    Layton, J.E.4    Krammer, P.H.5    Paul, W.E.6
  • 3
    • 0027493906 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39
    • Foy T.M., Shepherd D.M., Durie F.H., Aruffo A., Ledbetter J.A., and Noelle R.J. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med 178 (1993) 1567-1575
    • (1993) J Exp Med , vol.178 , pp. 1567-1575
    • Foy, T.M.1    Shepherd, D.M.2    Durie, F.H.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 5
    • 0031913668 scopus 로고    scopus 로고
    • IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells
    • Choe J., and Choi Y.S. IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells. Eur J Immunol 28 (1998) 508-515
    • (1998) Eur J Immunol , vol.28 , pp. 508-515
    • Choe, J.1    Choi, Y.S.2
  • 7
    • 0036073140 scopus 로고    scopus 로고
    • Role of BCR affinity in T cell dependent antibody responses in vivo
    • Shih T.A., Meffre E., Roederer M., and Nussenzweig M.C. Role of BCR affinity in T cell dependent antibody responses in vivo. Nat Immunol 3 (2002) 570-575
    • (2002) Nat Immunol , vol.3 , pp. 570-575
    • Shih, T.A.1    Meffre, E.2    Roederer, M.3    Nussenzweig, M.C.4
  • 9
    • 0037029607 scopus 로고    scopus 로고
    • Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced
    • Dal Porto J.M., Haberman A.M., Kelsoe G., and Shlomchik M.J. Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med 195 (2002) 1215-1221
    • (2002) J Exp Med , vol.195 , pp. 1215-1221
    • Dal Porto, J.M.1    Haberman, A.M.2    Kelsoe, G.3    Shlomchik, M.J.4
  • 10
    • 0032533470 scopus 로고    scopus 로고
    • Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers
    • Dal Porto J.M., Haberman A.M., Shlomchik M.J., and Kelsoe G. Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J Immunol 161 (1998) 5373-5381
    • (1998) J Immunol , vol.161 , pp. 5373-5381
    • Dal Porto, J.M.1    Haberman, A.M.2    Shlomchik, M.J.3    Kelsoe, G.4
  • 11
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano A., and Rajewsky K. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J 5 (1986) 2459-2468
    • (1986) EMBO J , vol.5 , pp. 2459-2468
    • Cumano, A.1    Rajewsky, K.2
  • 12
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek C., Berger A., and Apel M. Maturation of the immune response in germinal centers. Cell 67 (1991) 1121-1129
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 13
    • 0025213248 scopus 로고
    • V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin
    • Clarke S.H., Staudt L.M., Kavaler J., Schwartz D., Gerhard W.U., and Weigert M.G. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J Immunol 144 (1990) 2795-2801
    • (1990) J Immunol , vol.144 , pp. 2795-2801
    • Clarke, S.H.1    Staudt, L.M.2    Kavaler, J.3    Schwartz, D.4    Gerhard, W.U.5    Weigert, M.G.6
  • 16
    • 33645856486 scopus 로고    scopus 로고
    • Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
    • Using BCR transgenic mice that have varying affinities to the model antigen hen egg lysozyme, the authors showed that initial high BCR affinity drives naïve B cells to differentiate into extrafollicular plasma cells, whereas low-affinity B cells are driven into the GC B cells.
    • Paus D., Phan T.G., Chan T.D., Gardam S., Basten A., and Brink R. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med 203 (2006) 1081-1091. Using BCR transgenic mice that have varying affinities to the model antigen hen egg lysozyme, the authors showed that initial high BCR affinity drives naïve B cells to differentiate into extrafollicular plasma cells, whereas low-affinity B cells are driven into the GC B cells.
    • (2006) J Exp Med , vol.203 , pp. 1081-1091
    • Paus, D.1    Phan, T.G.2    Chan, T.D.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 17
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • Phan T.G., Paus D., Chan T.D., Turner M.L., Nutt S.L., Basten A., and Brink R. High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med 203 (2006) 2419-2424
    • (2006) J Exp Med , vol.203 , pp. 2419-2424
    • Phan, T.G.1    Paus, D.2    Chan, T.D.3    Turner, M.L.4    Nutt, S.L.5    Basten, A.6    Brink, R.7
  • 18
    • 0030925491 scopus 로고    scopus 로고
    • The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
    • Smith K.G., Light A., Nossal G.J., and Tarlinton D.M. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J 16 (1997) 2996-3006
    • (1997) EMBO J , vol.16 , pp. 2996-3006
    • Smith, K.G.1    Light, A.2    Nossal, G.J.3    Tarlinton, D.M.4
  • 20
    • 0033748344 scopus 로고    scopus 로고
    • B cell immunopoiesis: visualizing the impact of CD40 engagement on the course of T cell-independent immune responses in an Ig transgenic system
    • Erickson L.D., Vogel L.A., Cascalho M., Wong J., Wabl M., Durell B.G., and Noelle R.J. B cell immunopoiesis: visualizing the impact of CD40 engagement on the course of T cell-independent immune responses in an Ig transgenic system. Eur J Immunol 30 (2000) 3121-3131
    • (2000) Eur J Immunol , vol.30 , pp. 3121-3131
    • Erickson, L.D.1    Vogel, L.A.2    Cascalho, M.3    Wong, J.4    Wabl, M.5    Durell, B.G.6    Noelle, R.J.7
  • 22
    • 0032033127 scopus 로고    scopus 로고
    • Humoral immunity due to long-lived plasma cells
    • Slifka M.K., Antia R., Whitmire J.K., and Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity 8 (1998) 363-372
    • (1998) Immunity , vol.8 , pp. 363-372
    • Slifka, M.K.1    Antia, R.2    Whitmire, J.K.3    Ahmed, R.4
  • 23
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi N.L., Traggiai E., and Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298 (2002) 2199-2202
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 24
    • 0142188050 scopus 로고    scopus 로고
    • Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice
    • Rahman Z.S., Rao S.P., Kalled S.L., and Manser T. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 198 (2003) 1157-1169
    • (2003) J Exp Med , vol.198 , pp. 1157-1169
    • Rahman, Z.S.1    Rao, S.P.2    Kalled, S.L.3    Manser, T.4
  • 26
    • 27844541797 scopus 로고    scopus 로고
    • Control of B-cell responses by Toll-like receptors
    • Pasare C., and Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 438 (2005) 364-368
    • (2005) Nature , vol.438 , pp. 364-368
    • Pasare, C.1    Medzhitov, R.2
  • 29
    • 33644978463 scopus 로고    scopus 로고
    • Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells
    • Delogu A., Schebesta A., Sun Q., Aschenbrenner K., Perlot T., and Busslinger M. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24 (2006) 269-281
    • (2006) Immunity , vol.24 , pp. 269-281
    • Delogu, A.1    Schebesta, A.2    Sun, Q.3    Aschenbrenner, K.4    Perlot, T.5    Busslinger, M.6
  • 31
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • Shaffer A.L., Yu X., He Y., Boldrick J., Chan E.P., and Staudt L.M. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13 (2000) 199-212
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1    Yu, X.2    He, Y.3    Boldrick, J.4    Chan, E.P.5    Staudt, L.M.6
  • 32
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent A.L., Shaffer A.L., Yu X., Allman D., and Staudt L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 (1997) 589-592
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 33
    • 23444459544 scopus 로고
    • Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
    • Turner Jr. C.A., Mack D.H., and Davis M.M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77 (1994) 297-306
    • (1994) Cell , vol.77 , pp. 297-306
    • Turner Jr., C.A.1    Mack, D.H.2    Davis, M.M.3
  • 35
    • 28544444025 scopus 로고    scopus 로고
    • Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
    • Shapiro-Shelef M., Lin K.I., Savitsky D., Liao J., and Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med 202 (2005) 1471-1476
    • (2005) J Exp Med , vol.202 , pp. 1471-1476
    • Shapiro-Shelef, M.1    Lin, K.I.2    Savitsky, D.3    Liao, J.4    Calame, K.5
  • 37
    • 0036272784 scopus 로고    scopus 로고
    • Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells
    • Lin K.I., Angelin-Duclos C., Kuo T.C., and Calame K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol 22 (2002) 4771-4780
    • (2002) Mol Cell Biol , vol.22 , pp. 4771-4780
    • Lin, K.I.1    Angelin-Duclos, C.2    Kuo, T.C.3    Calame, K.4
  • 39
    • 3142658576 scopus 로고    scopus 로고
    • XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    • Shaffer A.L., Shapiro-Shelef M., Iwakoshi N.N., Lee A.H., Qian S.B., Zhao H., Yu X., Yang L., Tan B.K., Rosenwald A., et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21 (2004) 81-93
    • (2004) Immunity , vol.21 , pp. 81-93
    • Shaffer, A.L.1    Shapiro-Shelef, M.2    Iwakoshi, N.N.3    Lee, A.H.4    Qian, S.B.5    Zhao, H.6    Yu, X.7    Yang, L.8    Tan, B.K.9    Rosenwald, A.10
  • 40
    • 33745182931 scopus 로고    scopus 로고
    • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    • The IRF-4 gene was conditionally deleted in class-switched, post-germinal center B cells. The authors show that IRF-4 is required for plasma cell differentiation and implicate IRF-4 in the induction of AID and class-switch recombination.
    • Klein U., Casola S., Cattoretti G., Shen Q., Lia M., Mo T., Ludwig T., Rajewsky K., and Dalla-Favera R. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 7 (2006) 773-782. The IRF-4 gene was conditionally deleted in class-switched, post-germinal center B cells. The authors show that IRF-4 is required for plasma cell differentiation and implicate IRF-4 in the induction of AID and class-switch recombination.
    • (2006) Nat Immunol , vol.7 , pp. 773-782
    • Klein, U.1    Casola, S.2    Cattoretti, G.3    Shen, Q.4    Lia, M.5    Mo, T.6    Ludwig, T.7    Rajewsky, K.8    Dalla-Favera, R.9
  • 41
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 42
    • 1342287073 scopus 로고    scopus 로고
    • Developmentally distinct Th cells control plasma cell production in vivo
    • McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Developmentally distinct Th cells control plasma cell production in vivo. Immunity 20 (2004) 231-242
    • (2004) Immunity , vol.20 , pp. 231-242
    • McHeyzer-Williams, L.J.1    McHeyzer-Williams, M.G.2
  • 43
    • 33747133955 scopus 로고    scopus 로고
    • Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
    • These authors show that graded expression of IRF-4 drives the induction of either AID or Blimp-1 in B cells. Through genome-wide analysis, they find that IRF-4 regulates the Blimp-1-dependent plasma-cell differentiation program by interacting with a conserved region of the gene that encodes Blimp-1.
    • Sciammas R., Shaffer A.L., Schatz J.H., Zhao H., Staudt L.M., and Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25 (2006) 225-236. These authors show that graded expression of IRF-4 drives the induction of either AID or Blimp-1 in B cells. Through genome-wide analysis, they find that IRF-4 regulates the Blimp-1-dependent plasma-cell differentiation program by interacting with a conserved region of the gene that encodes Blimp-1.
    • (2006) Immunity , vol.25 , pp. 225-236
    • Sciammas, R.1    Shaffer, A.L.2    Schatz, J.H.3    Zhao, H.4    Staudt, L.M.5    Singh, H.6
  • 44
    • 0034654411 scopus 로고    scopus 로고
    • A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
    • Falini B., Fizzotti M., Pucciarini A., Bigerna B., Marafioti T., Gambacorta M., Pacini R., Alunni C., Natali-Tanci L., Ugolini B., et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95 (2000) 2084-2092
    • (2000) Blood , vol.95 , pp. 2084-2092
    • Falini, B.1    Fizzotti, M.2    Pucciarini, A.3    Bigerna, B.4    Marafioti, T.5    Gambacorta, M.6    Pacini, R.7    Alunni, C.8    Natali-Tanci, L.9    Ugolini, B.10
  • 45
    • 2142750272 scopus 로고    scopus 로고
    • Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation
    • Sciammas R., and Davis M.M. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol 172 (2004) 5427-5440
    • (2004) J Immunol , vol.172 , pp. 5427-5440
    • Sciammas, R.1    Davis, M.M.2
  • 46
    • 33644746220 scopus 로고    scopus 로고
    • Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    • Luckey C.J., Bhattacharya D., Goldrath A.W., Weissman I.L., Benoist C., and Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci USA 103 (2006) 3304-3309
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3304-3309
    • Luckey, C.J.1    Bhattacharya, D.2    Goldrath, A.W.3    Weissman, I.L.4    Benoist, C.5    Mathis, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.