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These authors show that graded expression of IRF-4 drives the induction of either AID or Blimp-1 in B cells. Through genome-wide analysis, they find that IRF-4 regulates the Blimp-1-dependent plasma-cell differentiation program by interacting with a conserved region of the gene that encodes Blimp-1.
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Sciammas R., Shaffer A.L., Schatz J.H., Zhao H., Staudt L.M., and Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25 (2006) 225-236. These authors show that graded expression of IRF-4 drives the induction of either AID or Blimp-1 in B cells. Through genome-wide analysis, they find that IRF-4 regulates the Blimp-1-dependent plasma-cell differentiation program by interacting with a conserved region of the gene that encodes Blimp-1.
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A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
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Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation
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Sciammas R., and Davis M.M. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol 172 (2004) 5427-5440
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Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
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Luckey C.J., Bhattacharya D., Goldrath A.W., Weissman I.L., Benoist C., and Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci USA 103 (2006) 3304-3309
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