Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model

Xenotransplantation

Volumn 14, Issue 3, 2007, Pages 243-248

  Mai, Gang ^a,b   Del Rio, Maria Luisa ^c,d   Tian, Jiong ^e   Ramirez, Pablo ^f   Buhler, Leo ^b   Rodriguez Barbosa, Jose Ignacio ^c,d  

^a SICHUAN UNIVERSITY   (China)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF LEÓN   (Spain)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e ZHEJIANG UNIVERSITY   (China)

^f HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

CD40 CD40L costimulatory pathway; Concordant islet xenotransplantation; PD 1 PD 1L inhibitory pathway

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; LIGAND; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 LIGAND; PROGRAMMED DEATH 1 MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY CAPSULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CD40 LIGAND; CRICETINAE; CRICETULUS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; GRAFT SURVIVAL; ISLETS OF LANGERHANS TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 34247881846     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2007.00402.x     Document Type: Article

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