Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells

Journal of Immunology

Volumn 163, Issue 2, 1999, Pages 787-793

  Revy, Patrick ^a   Hivroz, Claire ^b   Andreu, Georges ^c   Graber, Pierre ^d   Martinache, Chantal ^c   Fischer, Alain ^a   Durandy, Anne ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b INSTITUT CURIE   (France)

^c Etablissement Transfus Sang l'A   (France)

^d SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 3; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; STAT5A PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD40; B-LYMPHOCYTES; ENZYME ACTIVATION; HUMANS; INTERPHASE; JANUS KINASE 3; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TYROSINE;

EID: 0033565949     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Clark, E. A., and J. A. Ledbetter. 1986. Activation of human B cells mediated through two distinct cell surface differentiation antigens. Bp35 and Bp50. Proc. Natl. Acad. Sci. USA 83:4494.
2. Paulie, S., H. B. Ehlin, H. Mellstedt, H. Koho, A. H. Ben, and P. Perlmann. 1985. A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes. Cancer Immunol. Immunother. 20:23.
3. Hart, D. N., and J. L. McKenzie. 1988. Isolation and characterization of human tonsil dendritic cells. J. Exp. Med 168:157.
4. Galy, A. H., and H. Spits. 1992. CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 149:775.
5. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig chain isotypes in human B cells. J. Immunol. 152:438.
6. Zhang, K., E. A. Clark, and A. Saxon. 1991. CD40 stimulation provides an IFN-γ-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production. J. Immunol. 146:1836.
7. Rousset, P., E. Garcia, and I. Banchereau. 1991. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J. Exp. Med. 173:705.
8. Shapira, S. K., D. Vercelli, H. H. Jabara, S. M. Fu, and R. S. Geha. 1992. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of the CD40 antigen. J. Exp. Med. 175:289.
9. Spriggs, M. K., R. J. Armitage, L. Strockbine, K. N. Clifford, B. M. Macduff, T. A. Sato, C. R. Maliszewski, and W. C. Fanslow. 1992. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 176:1543.
10. +) B cells to secrete IgG1 and IgG3. J. Exp. Med. 179:757.
11. Lane, P., S. Traunecker, S. Hubele, S. Inui, A. Lanzavecchia, and D. Gray. 1992. Activated human T cells express a ligand for the human B cell-associated antigen CD40, which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22:2573.
12. Hollenbaugh, D., L. Grosmaire, D. Kullas, N. J. Chalupny, R. J. Noelle, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T-cell antigen gp39 a member of the TNF family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulating activity. EMBO J. 11:4313.
13. Lederman, S., M. J. Yellin, G. Inghirani, J. L. Lee, D. M. Knowles, and L. Chess. 1992. Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles: role of T cell-B cell activity molecule (5c8 antigen) and CD40 in contact-dependent help. J. Immunol. 149:3817.
14. Holder, M. J., H. Wang, A. E. M. Casamayor, R. Armitage, M. K. Spriggs, W. C. Fanslow, I. C. M. MacLennan, C. D. Gregory, and J. Gordon. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocyte by CD40 is independent of bcl2 induction. Eur. J. Immunol. 23:2368.
15. + T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur. J. Immunol. 24:3148.
16. Alderson, M., R. J. Armitage, T. W. Tough, L. Strockbine, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178:669.
17. Kiener, P. A., P. Moran-Davis, B. M. Rankin, A. F. Wahl, A. Ajuffo, and D. Hollenbaugh. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917.
18. Suttles, J., M. Evans, R. W. Miller, J. C. Poe, R. D. Stout, and L. M. Wahl. 1996. T cell rescue of monocytes from apoptosis: role of CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity. J. Leukocyte Biol. 60:651.
19. Cella, M., D. Scheidegger, K. Palmer-Lehman, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
20. + T-helper and a T-killer cell. Nature 393:474.
21. Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
22. Bennett, S. R. M., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. A. P. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature 393:478.
23. Soong, L., J. C. Xu, I. S Grewal, P. Kima, J. Sun, B. J. Longley, N. H. Ruddle, D. MacMahon-Pratt, and R. A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4:263.
24. Kamanaka, M., P. Yu, T. Yasui, K. Yoshida, T. Kawabe, T. Horii, T. Kishimoto, and H. Kikutani. 1996. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 4:275.
25. Campbell, K. A., P. J. Ovendale, M. K. Kennedy, W. C. Fanslow, S. G, Reed, and C. R. Maliszewski. 1996. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 4:283.
26. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
27. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal formation. Immunity 1:167.
28. Allen, R. C., R. J. Armitage, M. E. Conley, H. Rosenblatt, N. A. Jenkins, N. G. Copeland, M. A. Bedell, S. Edelhoff, C. M. Disteche, D. K. Simoneaux, et al. 1993. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259:990.
29. Aruffo, A., M. Farrington, D. Hollenbaugh, X. Li, A. Milatovitch, S. Nonoyama, J. Bajorath, L. S. Grosmaire, R. Stenkamp, M. Neubauer, et al. 1993. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 72:291.
30. Korthauer, U., D. Graf, H. W. Mages, F. Brière, M. Padayachee, S. Malcolm, A. G. Ugazio, L. D. Notarangelo, R. J. Levinsky, and R. A. Kroczek. 1993. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361:359.
31. DiSanto, J. P., J. Y. Bonnefoy, J. F. Gauchat, A. Fischer, and G. de Saint Basile. 1993. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature 361:541.
32. Fuleihan, R., N. Ramesh, R. Loh, H. Jabara, F. S. Rosen, T. Chatila, S. M. Fu, I. Stamenkovic, and R. Geha. 1993. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl. Acad. Sci. USA 90:2170.
33. Durandy, A., C. Hivroz, F. Mazerolles, C. Schiff, F. Bernard, E. Jouanguy, P. Revy, J. P. DiSanto, J. F. Gauchat, J. Y. Bonnefoy, et al. 1997. Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper IgM syndrome and normal CD40-ligand expression. J. Immunol. 158:2576.
34. Conley, M. E., M. Larch, V. R. Bonagura, A. R. Lawton III, R. H. Buckley, S. M. Fu, E. Coustan-Smith, H. G. Herrod, and D. Campana. 1994. Hyper IgM syndrome associated with defective CD40-mediated B cell activation. J. Clin. Invest. 94:1404.
35. Callard, R. E., S. H. Smith, J. Herbert, G. Morgan, M. Padayachee, S. Lederman, L. Chess, R. A. Kroczek, W. C. Fanslow, and R. J. Armitage. 1994. CD40 ligand (CD40L) expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM (HIM). J. Immunol. 153:3295.
36. Revy, P., F. Geissmann, M. Debré, A. Fischer, and A. Durandy. 1998. Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper IgM syndrome due to a CD40 pathway defect in B cells. Eur. J. Immunol. 28:3648.
37. Ren, C. L., T. Morio, S. M. Fu, and R. S. Geha. 1994. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med. 179:673.
38. Francis, D. A., J. G. Karras, X. Y. Ke, R. Sen, and T. L. Rothstein. 1994. Induction of the transcription factors NF-κB, AP-1, and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol. 7:151.
39. Berberich, I., G. L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates NF-κB. J. Immunol. 153:4357.
40. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424.
41. Hu, H. M., K. O'Rourke, M. S. Boguski, and V. M. Dixit. 1994. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269:30069.
42. Sato, T., S. Irie, and J. C. Reed. 1995. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358:113.
43. Cheng, G., A. M. Cleary, Z. S. Ye, D. I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494.
44. Cheng, G., and D. Baltimore. 1996. TANK, a co-inducer with TRAF2 of TNF- and CD40L-mediated NF-κB activation. Genes Dev. 10:963.
45. Rothe, M., M. G. Pan, W. J. Henzel, T. M. Ayres, and D. V. Goeddel. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83:1243.
46. Hanissian, S. H., and R. S. Geha. 1997. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379.
47. Karras, J. G., Z. Whang, L. Huo, D. A. Frank, and T. Rothstein. 1997. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes. J. Immunol. 159:4350.
48. Jabara, H. H., R. H. Buckley, J. L. Roberts, G. Lefranc, J. Loiselet, G. Khalil, and R. S. Geha. 1998. Role of JAK3 in CD40-mediated signaling. Blood 92:2435.
49. Faradji, A., A. Bohbot, M. Schmitt-Goguel, J. C. Siffert, S. Dumont, M. L. Wiesel, Y. Piemont, A. Eischen, J. P. Bergerat, J. Bartholeyns, P. Paindron, J. P. Witz, et al. 1994. Large scale isolation of human blood monocytes by continuous flow centrifugation leukapheresis and counterflow centrifugation elutriation for adoptive cellular immunotherapy in cancer patients. J. Immunol. Methods 174:297.
50. Mazzei, G. J., M. D. Edgerton, C. Losberger, S. Lecoanet-Henchoz, P. Graber, A. Durandy, J. F. Gauchat, A. Bernard, and J. Y. Bonnefoy. 1995. Recombinant soluble trimeric CD40 ligand is biologically active. J. Biol. Chem. 270:7025.
51. Gouilleux, F., C. Pallard, I. Dusanter-Fourt, H. Wakao, L. A. Haldosen, G. Norstedt, D. Levy, and B. Groner. 1995. Prolactin, growth hormone, erythropoietin, and granulocyte-macrophage colony-stimulating factor induce MGF-STAT5 DNA binding activity. EMBO J. 14:2005.
52. Hivroz-Burgaud, C., N. A. Clipstone, and D. A. Cantrell. 1991. Signaling requirements for the expression of the transactivating factor NF-AT in human T lymphocytes. Eur. J. Immunol. 21:2811.
53. Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, W. E. Thierfelder, B. Kreider, and O. Silvennoinen. 1994. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 19:222.
54. Wilks, A. F., and A. G. Harpur. 1994. Cytokine signal transduction and the JAK family of protein tyrosine kinases. Bioessays 16:313.
55. Pelligrini, S., and I. Dusanter-Fourt. 1997. The structure, regulation, and function of the Janus Kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur. J. Biochem. 248:615.
56. Jeppson, J. D., H. R. Patel, N. Sakata, J. Domenico, N. Terada, and E. W. Gelfand. 1998. Requirement for dual signals by anti-CD40 and IL-4 for the induction of NF-κB, IL-6, and IgE in human B lymphocytes. J. Immunol. 161: 1738.
57. Rosen, R. L., K. D. Winestock, G. Chen, X. Liu, L. Hennighausen, and D. S. Finbloom. 1996. Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kDa STATSA and an 80-kDa STAT5A isoform in human peripheral blood monocytes. Blood 88:1206.
58. Lokuta, M. A., M. A. McDowell, and D. M. Paulnock. 1998. Identification of an additional isoform of STATS expressed in immature macrophages. J. Immunol. 161:1594.
59. Tortolani, P. J., B. K. Lal, A. Riva, J. A. Johnston, Y Q. Chen, G. H. Reaman, M. Beckwith, D. Longo, J. R. Ortaldo, K. Bhatia, et al. 1995. Regulation of Jak3 expression and activation in human B cells and B cell malignancies. J. Immunol. 155:5220.
60. Oakes, S. A., F. Candotti, J. A. Johnston, Y. Chen, J. J. Ryan, N. Taylor, X. Liu, L. Hennighausen, L. D. Notarangelo, W. E. Paul, et al. 1996. Signaling via IL-2 and IL-4 in JAK-deficient severe combined immunodeficiency lymphocytes: Jak3-dependent and -independent pathways. Immunity 5:605.
61. Keegan, A. D., J. A. Johnston, P. J. Tortolani, M. J. McReynolds, C. Kinzer, J. J. O'Shea, and W. E. Paul. 1995. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc. Natl. Acad. Sci. USA 92:7681.
62. Krajewski, S., J. M. Zapata, M. Krajewska, T. van Arsdale, A. Shabaik, R. D. Gascoyne, and J. C. Reed. 1997. Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family. J. Immunol. 159:5841.
63. Grammer, A. C., J. L. Swantek, R. D. McFarland, Y. Miura, T. Geppert, and P. E. Lipsky. 1998. TNF receptor-associated factor-3 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells. J. Immunol. 161:1183.