CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance

Transplantation

Volumn 76, Issue 9, 2003, Pages 1375-1379

  Jarvinen, Lamis Z ^a   Blazar, Bruce R ^b   Adeyi, Oyedele A ^a   Strom, Terry B ^c   Noelle, Randolph J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; INTERLEUKIN 2 RECEPTOR; NEUTRALIZING ANTIBODY;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; BLOOD DONOR; BLOOD TRANSFUSION; CELL SURFACE; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOREGULATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TIME;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; GRAFT REJECTION; GRAFT SURVIVAL; HOMEODOMAIN PROTEINS; IMMUNE TOLERANCE; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0242660129     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000093462.16309.73     Document Type: Article

References (23)

1. Biancone L, Cantaluppi V, Camussi G. CD40-CD154 interaction in experimental and human disease (review). Int J Mol Med 1999; 3: 343.
2. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
3. Parker DC, Greiner DL, Phillips NE, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A 1995; 92: 9560.
4. Markees T, Phillips N, Gordon E, et al. Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody. Transplant Proc 1998; 30: 2444.
5. Zheng XX, Li Y, Li XC, et al. Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts. Transplant Proc 1999; 31: 627.
6. van Maurik A, Herber M, Wood KJ, et al. Cutting edge: CD4(+)CD25(+) alloantigen-specific immunoregulatory cells that can prevent CD8(+) T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 2002; 169: 5401.
7. Taylor PA, Friedman TM, Korngold R, et al. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002; 99: 4601.
8. Brennan DC, Mohanakumar T, Flye MW. Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: a review of efficacy and mechanisms. Am J Kidney Dis 1995; 26: 701.
9. Okazaki H, Maki T, Wood M, et al. Effect of a single transfusion of donor-specific and nonspecific blood on skin allograft survival in mice. Transplantation 1980; 30: 421.
10. Markees TG, Phillips NE, Gordon EJ, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest 1998; 101: 2446.
11. Buhlmann JE, Foy TM, Aruffo A, et al. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 1995; 2: 645.
12. Li YY, Baccam M, Waters SB, et al. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. J Immunol 1996; 157: 1440.
13. Noelle RJ, Roy M, Shepherd DM, et al. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci U S A 1992; 89: 6550.
14. Sutmuller RP, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001; 194: 823.
15. Li Y, Li XC, Zheng XX, et al. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298.
16. Itoh M, Takahashi T, Sakaguchi N, et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 5317.
17. Graca L, Honey K, Adams E, et al. Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol 2000; 165: 4783.
18. Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via cost/mulatory blockade. J Exp Med 2001; 193: 1311.
19. Griggs ND, Agersborg SS, Noelle RJ, et al. The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells. J Exp Med 1996; 183: 801.
20. Smith KM, Pottage L, Thomas ER, et al. Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. J Immunol 2000; 165: 3136.
21. Grewal IS, Foellmer HG, Grewal KD, et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 1996; 273: 1864.
22. Liu Z, Geboes K, Colpaert S, et al. Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions. J Immunol 2000; 164: 6005.
23. Bingaman AW, Ha J, Durham MM, et al. Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4 + T cells in vivo. Transplantation 2001; 72: 1286.