Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas

Clinical Cancer Research

Volumn 9, Issue 6, 2003, Pages 2204-2212

  Takahiro, Tajino ^a   Shinichi, Kikuchi ^a   Toshimitsu, Suzuki ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; KI 67 ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHONDROSARCOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LEIOMYOSARCOMA; LIPOSARCOMA; MAJOR CLINICAL STUDY; MALE; MALIGNANT FIBROUS HISTIOCYTOMA; NERVE SHEATH TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RHABDOMYOSARCOMA; SOFT TISSUE SARCOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; KI-67 ANTIGEN; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; SARCOMA;

EID: 0038176163     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Wakil, S. J. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry, 28: 4523-4530, 1989.
2. Smith, S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. FASEB J., 8: 1248-1259, 1994.
3. Semenkovich, C. F. Regulation of fatty acid synthase (FAS). Prog. Lipid Res., 36: 43-53, 1997.
4. Weiss, L., Hoffmann, G. E., Schreiber, R., Andres, H., Fuchs, E., Körber, E., and Kolb, H. J. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol. Chem. Hoppe-Seyler, 367: 905-912, 1986.
5. Amy, C. M., Williams-Ahlf, B., Naggert, J., and Smith, S. Molecular cloning of the mammalian fatty acid synthase gene and identification of the promoter region. Biochem. J., 271: 675-679, 1990.
6. Escot, C., Joyeux, C., Mathieu, M., Maudelonde, T., Pages, A., Rochefort, H., and Chalbos, D. Regulation of fatty acid synthase ribonucleic acid in the human endometrium during the menstrual cycle. J. Clin. Endocrinol. Metab., 70: 1319-1324, 1990.
7. Pope, T. S., Smart, D. A., and Rooney, S. A. Hormonal effects on fatty-acid synthase in cultured fetal rat lung; induction by dexamethasone and inhibition of activity by triiodothyronine. Biochim. Biophys. Acta, 959: 169-177, 1988.
8. Xu, Z. X., Stenzel, W., Sasic, S. M., Smart, D. A., and Rooney, S. A. Glucocorticoid regulation of fatty acid synthase gene expression in fetal rat lung. Am. J. Physiol., 265: L140-L147, 1993.
9. Smith, S., and Ryan, P. Asynchronous appearance of two enzymes concerned with medium chain fatty acid synthesis in developing rat mammary gland. J. Biol. Chem., 254: 8932-8936, 1979.
10. Thompson, B. J., and Smith, S. Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat. Pediatr. Res., 19: 139-143, 1985.
11. Joyeux, C., Chalbos, D., and Rochefort, H. Effects of progestins and menstrual cycle on fatty acid synthetase and progesterone receptor in human mammary glands. J. Clin. Endocrinol. Metab., 70: 1438-1444, 1990.
12. Kuhajda, F. P., Katumuluwa, A. I., and Pasternack, G. R. Expression of haptoglobin-related protein and its potential role as a tumor antigen. Proc. Natl. Acad. Sci. USA, 86: 1188-1192, 1989.
13. Kuhajda, F. P., Piantadosi, S., and Pasternack, G. R. Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. N. Engl. J. Med., 321: 636-641, 1989.
14. Shurbaji, M. S., Pasternack, G. R., and Kuhajda, F. P. Expression of haptoglobin-related protein in primary and metastatic breast cancers. A longitudinal study of 48 fatal tumors. Am. J. Clin. Pahol., 96: 238-242, 1991.
15. Jensen, V., Ladekarl, M., Holm-Nielsen, P., Melsen, F., and Soerensen, F. B. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer. J. Pathol., 176: 343-352, 1995.
16. Alò, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C., and Di Tondo, U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer (Phila.), 77: 474-482, 1996.
17. Milgraum, L. Z., Witters, L. A., Pasternack, G. R., and Kuhajda, F. P. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res., 3: 2115-2120, 1997.
18. Alò, P. L., Visca, P., Trombetta, G., Mangoni, A., Lenti, L., Monaco, S., Botti, C., Serpieri, D. E., and Di Tondo, U. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori, 85: 35-40, 1999.
19. Shurbaji, M. S., Kuhajda, F. P., Pasternack, G. R., and Thurmond, T. S. Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator. Am. J. Clin. Pathol., 97: 686-691, 1992.
20. Epstein, J. I., Carmichael, M., and Partin, A. W. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology, 45: 81-86, 1995.
21. Shurbaji, M. S., Kalbfleisch, J. H., and Thurmond, T. S. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum. Pathol., 27: 917-921, 1996.
22. Gansler, T. S., Hardman, W., Hunt, D. A., Schaffel, S., and Hennigar, R. A. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum. Pathol., 28: 686-692, 1997.
23. Rashid, A., Pizer, E. S., Moga, M., Milgraum, L. Z., Zahurak, M., Pasternack, G. R., Kuhajda, F. P., and Hamilton, S. R. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am. J. Pathol., 150: 201-208, 1997.
24. Visca, P., Alò, P. L., Del Nonno, F., Botti, C., Trombetta, G., Marandino, F., Filippi, S., Di Tondo, U., and Donnorso, R. P. Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. Clin. Cancer Res., 5: 4111-4118, 1999.
25. Pizer, E. S., Lax, S. F., Kuhajda, F. P., Pasternack, G. R., and Kurman, R. J. Fatty acid synthase expression in endometrial carcinoma. Correlation with cell proliferation and hormone receptors. Cancer (Phila.), 83: 528-537, 1998.
26. Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., and Pasternack, G. R. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc. Natl. Acad. Sci. USA, 91: 6379-6383, 1994.
27. Vance, D., Goldberg, I., Mitsuhashi, O., and Bloch, K. Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem. Biophys. Res. Commun., 48: 649-656, 1972.
28. Omura, S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol. Rev., 40: 681-697, 1976.
29. Funabashi, H., Kawaguchi, A., Tomoda, H., Omura, S., Okuda, S., and Iwasaki, S. Binding site cerulenin in fatty acid synthetase. J. Biochem. (Tokyo), 105: 751-755, 1989.
30. Pizer, E. S., Wood, F. D., Pasternack, G. R., and Kuhajda, F. P. Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res., 56: 745-751, 1996.
31. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., and Kuhajda, F. P. Inhibition of fatty acid synthesis induced programmed cell death in human breast cancer cells. Cancer Res., 56: 2745-2747, 1996.
32. Furuya, Y., Akimoto, S., Yasuda, K., and Ito, H. Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis. Anticancer Res., 17: 4589-4594, 1997.
33. Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., and Han, W. F. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res., 58: 4611-4615, 1998.
34. Pizer, E. S., Wood, F. D., Heine, H. S., Romantsev, F. E., Pasternack, G. R., and Kuhajda, F. P. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res., 56: 1189-1193, 1996.
35. Weiss, S. W., and Goldblum, J. R. Enzinger and Weiss's Soft Tissue Tumors, 4th ed., pp. 1-2. St. Louis, MO: Mosby Inc., 2001.
36. Ueda, T., Aozasa, K., Tsujimoto, M., Ohsawa, M., Uchida, A., Aoki, Y., Ono, K., and Matsumoto, K. Prognostic significance of Ki-67 reactivity soft tissue sarcomas. Cancer (Phila.), 63: 1607-1611, 1989.
37. Drobnjak, M., Latres, E., Pollack, D., Karpeh, M., Dubas, M., Woodruff, J. M., Brennan, M. F., and Cordon-Cardo, C. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. J. Natl. Cancer Inst. (Bethesda), 86: 549-554, 1994.
38. Choong, P. F. M., Åkerman, M., Willén, H., Andersson, C., Gustafson, P., Baldetorp, B., Fernö, M., Alvegård, T., and Rydholm, A. Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation-a marker of metastasis? APMIS, 102: 915-924, 1994.
39. Choong, P. F. M., Åkerman, M., Willén, H., Andersson, C., Gustafson, P., Alvegård, T., and Rydholm, A. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in soft tissue sarcoma. Is prognostic significance histotype-specific? APMIS, 103: 797-805, 1995.
40. Levine, E. A., Holzmayer, T., Bacus, S., Mechetner, E., Mera, R., Bolliger, C., Roninson, I. B., and Das Gupta, T. K. Evaluation of newer prognostic markers for adult soft tissue sarcomas. J. Clin. Oncol., 15: 3249-3257, 1997.
41. Rudolph, P., Kellner, U., Chassevent, A., Collin, F., Bonichon, F., Parwaresch, R., and Coindre, J. M. Prognostic relevance of a novel proliferation marker, Ki-S11, for soft-tissue sarcoma. A multivariate study. Am. J. Pathol., 150: 1997-2007, 1997.
42. Kawai, A., Noguchi, M., Beppu, Y., Yokoyama, R., Mukai, K., Hirohashi, S., Inoue, H., and Fukuma, H. Nuclear immunoreaction of p53 protein in soft tissue sarcomas. A possible prognostic factor. Cancer (Phila.), 73: 2499-2505, 1994.
43. Nakanishi, H., Ohsawa, M., Naka, N., Uchida, A., Ochi, T., and Aozasa, K. Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis. Oncology (Basel), 54: 238-244, 1997.
44. Würl, P., Taubert, H., Meye, A., Berger, D., Lautenschläger, C., Holzhausen, H. J., Schmidt, H., Kalthoff, H., Rath, F. W., and Dralle, H. Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: a multivariate analysis of five antibodies. J. Cancer Res. Clin. Oncol., 123: 502-508, 1997.
45. Cordon-Cardo, C., Latres, E., Drobnjak, M., Oliva, M. R., Pollack, D., Woodruff, J. M., Marechal, V., Chen, J., Brennan, M. F., and Levine, A. J. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res., 54: 794-799, 1994.
46. Würl, P., Meye, A., Schmidt, H., Lautenschläger, C., Kalthoff, H., Rath, F. W., and Taubert, H. High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities. Oncogene, 16: 1183-1185, 1998.
47. Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., and Suzuki, T. Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J. Histochem. Cytochem., 48: 613-622, 2000.
48. Enneking, W. F. Muskuloskeletal Tumor Surgery, Vol. 1, pp. 90-95. New York: Churchill Livingstone, Inc., 1983.
49. Enzinger, F. M., and Weiss, S. W. Soft Tissue Tumors, 3rd ed., pp. 4-12. St. Louis, MO: Mosby-Year Book, Inc., 1995.
50. Kaplan, E. L., and Meier, P. Nonparametric estimation from incomplete observation. J. Am. Stat. Assoc., 53: 457-481, 1958.
51. Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., and Smith, P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br. J. Cancer, 35: 1-39, 1977.
52. Cox, D. R. Regression models and life tables. J. R. Stat. Soc., 34: 187-220, 1972.
53. Coindre, J. M., Nguyen, B. B., Bonichon, F., de Mascarel, I., and Trojani, M. Histopathologic grading in spindle cell soft tissue sarcomas. Cancer (Phila.), 61: 2305-2309, 1988.
54. Tsujimoto, M., Aozasa, K., Ueda, T., Morimura, Y., Komatsubara, Y., and Doi, T. Multivariate analysis for histologic prognostic factors in soft tissue sarcomas. Cancer (Phila.), 62: 994-998, 1988.
55. Coindre, J. M., Terrier, P., Bui, N. B., Bonichon, F., Collin, F., Le Doussal, V., Mandard, A. M., Vilain, M. O., Jacquemier, J., Duplay, H., Sastre, X., Barlier, C., Henry-Amar, M., Mace-Lesech, J., and Contesso, G. Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J. Clin. Oncol., 14: 869-877, 1996.
56. Kuhajda, F. P. Fatty acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition, 16: 202-208, 2000.
57. Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., and Stein, H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol., 133: 1710-1715, 1984.
58. Würl, P., Lautenschläger, C., Meye, A., Schmidt, H., Bache, M., Rath, F. W., Schönfelder, M., and Taubert, H. A multifactorial prognostic model for adult soft tissue sarcoma considering clinical, histopathological and molecular data. Anticancer Res., 20: 2065-2072, 2000.