Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas

Human Pathology

Volumn 38, Issue 9, 2007, Pages 1351-1360

  Conde, Esther ^a,b   Suarez Gauthier, Ana ^a   García García, Elena ^b   Lopez Rios, Fernando ^b   Lopez Encuentra, Angel ^b   García Lujan, Ricardo ^b   Morente, Manuel ^a   Sanchez Verde, Lydia ^a   Sanchez Cespedes, Montserrat ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

ACC; AMPK; LKB1 or STK11; Lung cancer; Peutz Jeghers syndrome

Indexed keywords

CARBOXYLASE; PHOSPHO ACETYL COENZYME A CARBOXYLASE; PROTEIN KINASE LKB1; UNCLASSIFIED DRUG;

ARTICLE; CANCER SURVIVAL; CELL POLARITY; CONTROLLED STUDY; CYTOSOL; ENZYME INACTIVATION; EPITHELIUM; EPITHELIUM CELL; GLIA CELL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; LUNG ADENOCARCINOMA; LUNG CARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; MUSCLE CELL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEMINIFEROUS TUBULE; SKELETAL MUSCLE;

ACETYL-COA CARBOXYLASE; ADENOCARCINOMA; CARCINOMA; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; PHOSPHORYLATION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL;

EID: 34547828813     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.01.022     Document Type: Article

References (30)

1. Spicer J., and Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. Curr Biol 14 (2004) R383-R385
2. Hemminki A., Markie D., Tomlinson I., et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 18 (1998) 184-187
3. Jenne D.E., Reimann H., Nezu J., et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet 18 (1998) 38-44
4. Giardiello F.M., Welsh S.B., Hamilton S.R., et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316 (1987) 1511-1514
5. Sanchez-Cespedes M., Parrella P., Esteller M., et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 62 (2002) 3659-3662
6. Carretero J., Medina P.P., Pio R., Montuenga L.M., and Sanchez-Cespedes M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 23 (2004) 4037-4040
7. Smith D.P., Spicer J., Smith A., Swift S., and Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 8 (1999) 1479-1485
8. Su G.H., Hruban R.H., Bansal R.K., et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154 (1999) 1835-1840
9. Martin S.G., and St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421 (2003) 379-384
10. Watts J.L., Morton D.G., Bestman J., and Kemphues K.J. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127 (2000) 1467-1475
11. Baas A.F., Kuipers J., van der Wel N.N., et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 16 (2004) 457-466
12. Szczepañska K., and Maleszewski M. LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle. Gene Expr Patterns 6 (2005) 86-93
13. Yoo L.I., Chung D.C., and Yuan J. LKB1, a master tumour suppressor of the small intestine and beyond. Nat Rev 2 (2002) 529-535
14. Tiainen M., Ylikorkala A., and Makela T.P. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A 96 (1999) 9248-9251
15. Karuman P., Gozani O., Odze R.D., et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7 (2001) 1307-1319
16. Jimenez A.I., Fernandez P., Dominguez O., Dopazo A., and Sanchez-Cespedes M. Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway. Cancer Res 63 (2003) 1382-1388
17. Woods A., Johnstone S.R., Dickerson K., et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13 (2003) 2004-2008
18. Shaw R.J., Kosmatka M., Bardeesy N., et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 101 (2004) 3329-3335
19. Hawley S.A., Pan D.A., Mustard K.J., et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2 (2005) 9-19
20. Carretero J., Medina P.P., Blanco R., et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene 26 (2007) 1616-1625
21. Conde E., Angulo B., Tang M., et al. Molecular context of the epidermal growth factor receptor mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res 12 (2006) 710-717
22. Ha J., Lee J.K., Kim K.S., Witters L.A., and Kim K.H. Cloning of human acetyl-CoA carboxylase-8 and its unique features. Proc Natl Acad Sci U S A 93 (1996) 11466-11470
23. Rowan A., Churchman M., Jefferey R., Hanby A., Poulsom R., and Tomlinson I. In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours. J Pathol 192 (2000) 203-206
24. Boudeau J., Baas A.F., Deak M., et al. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22 (2003) 5102-5114
25. Kudo N., Barr A.J., Barr R.L., Desai S., and Lopaschuk G.D. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270 (1995) 17513-17520
26. Young L.H., Li J., Baron S.J., and Russell R.R. AMP-activated protein kinase: a key stress signaling pathway in the heart. Trends Cardiovasc Med 15 (2005) 110-118
27. Sakamoto K., McCarthy A., Smith D., et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 24 (2005) 1810-1820
28. Sahin F., Maitra A., Argani P., et al. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol 16 (2003) 686-691
29. Ghaffar H., Sahin F., Sanchez-Cespedes M., et al. LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res 9 (2003) 2998-3003
30. Sanchez-Cespedes M. Dissecting the genetic alterations involved in lung carcinogenesis. Lung Cancer 40 (2003) 111-121