Involvement of extracellular signal-regulated kinase 2 and stress- activated protein kinase/Jun N-terminal kinase activation by transforming growth factor β in the negative growth control of breast cancer cells

Cancer Research

Volumn 57, Issue 4, 1997, Pages 628-633

  Frey, Randall S ^a   Mulder, Kathleen M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELL LINE; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031059867     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Roberts, A. B., and Sporn, M. B. The transforming growth factor-betas. In: M. B. Sporn and A. B. Roberts (eds.), Peptides, Growth Factors and Their Receptors, pp. 419-472. Berlin: Springer-Verlag, 1990.
2. Moses, H. L., Yang, E. Y., and Pietenpol, J. A. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell, 63: 245-247, 1990.
3. Massagué, J. The transforming growth factor-β family. Annu. Rev. Cell Biol., 6: 597-641, 1990.
4. Lin, H. Y., and Lodish, H. F. Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases. Trends Cell Biol., 3: 14-19, 1993.
5. Sporn, M. B., and Roberts, A. B. Peptide growth factors are multifunctional. Nature (Lond.), 332: 217-219, 1988.
6. Lin, H. Y., Wang, X-F., Ng-Eaton, E., Weinberg, R. A., and Lodish, H. F. Expression cloning of the TGF-β type-II receptor, a functional transmembrane serine/threonine kinase. Cell, 68: 775-785, 1992.
7. Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C-H., and Myazono, K. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell, 75: 681-692, 1993.
8. Attisano, L., Cárcamo, J., Ventura, F., Weis, F. M. B., Massagué, J., and Wrana, J. L. Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors. Cell, 75: 671-680, 1993.
9. Derynck, R. TGF-β-receptor mediated signaling. Trends Biochem. Sci., 19: 548-552, 1994.
10. Wang, T., Donahoe, P. K., and Servos, A. S. Specific interactions of type I receptors of the TGFβ family with the immunophilin FKBP-12. Science (Washington DC), 205: 674-676, 1994.
11. Chen, R-H., Miettinen, P. J., Maruoka, E. M., Choy, L., and Derynck, R. A WD- domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature (Lond.), 377: 548-552, 1995.
12. Kawataba, M., Imamura, T., Miyazono, K., Engel, M. E., and Moses, H. L. Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-α. J. Biol. Chem., 270: 29628-29631, 1995.
13. 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCL64 cells. EMBO J., 10: 1083-1089, 1991.
14. Reynisdóttir, I., Polyak, K., Iavarone, A., and Massagué. Kip/Cip and Ink4 inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9: 1831- 1845, 1995.
15. 1 cyclin-dependent kinases. Genes Dev., 9: 1149-1163, 1995.
16. Alexandrow, M. G., and Moses, H. L. Transforming growth factor β and cell cycle regulation. Cancer Res., 55: 1452-1457, 1995.
17. Peter, M., and Herskowitz, I. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell, 79: 181-184, 1994.
18. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
19. ras by transforming growth factor β in epithelial cells. J. Biol. Chem., 267: 5029-5031, 1992.
20. mapk in proliferating cultures of epithelial cells. J. Biol. Chem., 270: 7117-7124, 1995.
21. Hartsough, M. T., Frey, R. S., Zipfel, P. A., Buard, A., Cook, S. J., McCormick, F., and Mulder, K. M. Altered TGFβ signaling in epithelial cells when ras activation is blocked. J. Biol. Chem., 271: 22368-22375, 1996.
22. Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., and Matsumoto, K. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science (Washington, DC), 270: 2008-2011, 1995.
23. Sánchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M., and Zon, L. I. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (Lond.), 372: 794-798, 1994.
24. Moriguchi, T., Kawasaki, H., Matsuda, S., Gotoh, Y., and Nishida, E. Evidence for multiple activators for stress-activated protein kinases/c-Jun amino-terminal kinases. J. Biol. Chem., 270: 12969-12972, 1995.
25. Yan, M., Dai, T., Deak, J. C., Kyriakis, J. M., Zon, L. I., Woodgett, J. R., and Templeton, D. J. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (Lond.), 372: 798-800, 1994.
26. Arteaga, C. L., Tandon, A. K., VonHoff, D. D., and Osborne, C. K. Transforming growth factor β: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res., 48: 3898-3904, 1988.
27. Sun, L., Wu, G., Willson, J. K. V., Zborowska, E., Yang, J., Rajkarunanayake, L. Wang, J., Gentry, L. E., Wang, X. F., and Brattain, M. G. Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem., 269: 26449-26455, 1994.
28. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. R., Avruch, J., and Woodgett, J. R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature (Lond.), 369: 156-160, 1994.
29. Zhou, G-H. K., Sechrist, G. L., Periyasamy, S., Brattain, M. G., and Mulder, K. M. Transforming growth factor β isoform-specific differences in interactions with type I and II transforming growth factor β receptors. Cancer Res., 55: 2056-2062, 1995.
30. Zhou, G. H., Sechrist, G. L., Brattain, M. G., and Mulder, K. M. Clonal heterogeneity of the sensitivity of human colon carcinoma cell lines to TGF-β isoforms. J. Cell. Physiol., 165: 512-520, 1995.
31. Moustakis, A., Lin, H. Y., Henis, Y. I., Plamondon, J., O'Connor-McCourt, D., and Lodish, H. F. The transforming growth factor β receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand. J. Biol. Chem., 268: 22215- 22218, 1993.
32. Kalkhoven, E., Roelen, B. A. J., de Winter, J. P., Mummery, C. L., van den Eijnden-van Raaij, A. J. M., van der Saag, P. T., and van der Burg, B. Resistance to transforming growth factor β and activin due to reduced receptor expression in human breast tumor cell lines. Cell Growth & Differ., 6: 1151-1161, 1995.
33. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B., Davis, R. J., Johnson, G. L., and Karin, M. Differential activation of ERK and JNK mitogen- activated protein kinases by Raf-1 and MEKK. Science (Washington DC), 266: 1719-1723, 1994.
34. Jeoung, D. I., Tang, B., and Sonenberg, M. Effects of tumor necrosis factor on antimitogenicity and cell cycle related proteins in MCF-7 cells. J. Biol. Chem., 270: 18367-18373, 1995.
35. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (Washington DC), 270: 1326-1331, 1995.
36. Mane, B. M., Graus-Porta, D., Jeschke, M., Fabbro, D., Hynes, N. E., and Taverna, D. NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells. Oncogene, 10: 167-175, 1995.
37. Janes, P. W., Daly, R. J., deFazio, A., and Sutherland, R. L. Activation of the ras signaling pathway in human breast cancer cells overexpressing erbB-2. Oncogene, 9: 3601-3608, 1994.
38. Buard, A., Zipfel, P. A., Frey, R. S., and Mulder, K. M. Maintenance of signaling through Ras in human colon carcinoma cells with K-ras mutations. Int. J. Cancer, 67: 539-546, 1996.
39. 2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. Cell Growth & Differ., 6: 1437-1446, 1995.
40. Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J., and Bokoch, G. M. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem., 270: 23934-23936, 1995.
41. Bagrodia, S., Dérijard, B., Davis, R. J., and Cerione, R. A. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem., 270: 27995-27998, 1995.
42. 13. J. Biol. Chem., 270: 18655-18659, 1995.
43. Minden, A., Lin, A., Smeal, T., Dérijard, B., Cobb, M., Davis, R., and Karin, M, c-Jun terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol., 14: 6683- 6688, 1994.
44. Vojtek, A. B., and Cooper, J. A. Rho family members: activators of MAP kinase cascades. Cell, 82: 527-529, 1995.
45. Centrella, M., McCarthy, T. L., and Canalis, E. Transforming growth factor β is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J. Biol. Chem., 262: 2869-2874, 1987.
46. Ohta, S., Hiraki, Y., Shigeno, C., Suzuki, F., Kasai, R., Ikeda, T., Kohno, H., Lee, K., Kikuchi, H., Konishi, J., Bentz, H., Rosen, D. M., and Yamamuro, T. Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells. FEBS Lett., 314: 356-360, 1992.
47. Chatani, Y., Tanimura, S., Miyoshi, N., Hattori, A., Sato, M., and Kohno, M. Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation. J. Biol. Chem., 270: 30686-30692, 1995.
48. Yan, Z., Winawer, S., and Friedman, E. Two different signal transduction pathways can be activated by transforming growth factor β1 in epithelial cells. J. Biol. Chem., 269: 13231-13237, 1994.
49. 1 on mitogenic response, transforming growth factor α and c-myc in quiescent, well-differentiated colon carcinoma cells. Cancer Res., 50: 7581-7586, 1990.
50. Mulder, K. M., Humphrey, L. E., Choi, H. G., Childress-Fields, K. E., and Brattain, M. G. Evidence for c-myc in the signaling pathway for TGF-β in well differentiated human colon carcinoma cells. J. Cell. Physiol., 145: 501-507, 1990.
51. Mulder, K. M. Differential regulation of c-myc and transforming growth factor-α messenger RNA expression in poorly differentiated and well-differentiated colon carcinoma cells during establishment of a quiescent state. Cancer Res., 51: 2256- 2262, 1991.
52. Leof, E. B., Proper, J. A., Goustin, A. S., Shipley, G. D., DiCorletto, P. E., and Moses, H. L. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: a proposed model for indirect mitogenesis involving autocrine activity. Proc. Natl. Acad. Sci. USA., 83: 2453-2457, 1986.
53. Seifert, R. A., Coats, S. A., Raines, E. W., Ross, R., and Bowen-Pope, D. F. Platelet-derived growth factor (PDGF) receptor α-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-β can be mitogenic through PDGF A-chain-dependent and -independent pathways. J. Biol. Chem., 269: 13951- 13955, 1994.
54. Majack, R. A., Majesky, M. W., and Goodman, L. V. Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-β. J. Cell Biol., 111: 239-247, 1990.
55. 1, epidermal growth factor, and N,N-dimethylformamide in human colon carcinoma cells. Cell Growth & Differ., 4: 637-645, 1993.
56. 1 growth arrest by transforming growth factor β1 requires cellular ras activity. J. Biol. Chem., 268: 21448-21452, 1993.
57. Diaz-Meco, M. T., Dominguez, I., Sanz, L., Municio, M. M., Berra, E., Cornet, M. E., De Herreros, A. G., Johansen, T., and Moscat, J. Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor β1 inhibitory signals. Mol. Cell. Biol., 12: 302-308, 1992.
58. 1in cycling epithelial cells. Cell Growth & Differ., 6: 915-925, 1995.
59. WAF1 and p53 requires c-raf-1. Cancer Res., 55: 4623-4626, 1995.