Physical and functional interactions between type I transforming growth factor β receptors and Bα, a WD-40 repeat subunit of phosphatase 2A

Molecular and Cellular Biology

Volumn 18, Issue 11, 1998, Pages 6595-6604

  Griswold Prenner, Irene ^a,c   Kamibayashi, Craig ^b   Maruoka, E Miko ^a   Mumby, Marc C ^b   Derynck, Rik ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Athena Neurosciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL TRANSFORMATION; ENZYME ACTIVITY; ENZYME ASSAY; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 0031741865     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.11.6595     Document Type: Article

References (50)

1. Alessi, D. R., N. Gomez, G. Moorhead, T. Lewis, S. M. Keyse, and P. Cohen. 1995. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Curr. Biol. 5:283-295.
2. Andersson, S., D. L. Davis, H. Dahlback, H. Jornvall, and D. W. Russell. 1989. Cloning, structure, and expression of the mitrochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264:8222-8229.
3. Bussing, C. H., J. M. Yingling, D. J. Howe, T. Wang, W. W. He, M. L. Gustafson, P. Shah, P. K. Donahoe, and X.-F. Wang. 1993. A transforming growth factor β type I receptor that signals to activate gene expression. Science 263:87-89.
4. Brand, T., and M. D. Schneidert. 1995. Inactive type II and type I receptors for TGF β are dominant inhibitors of TGF beta-dependent transcription. J. Biol. Chem. 270:8274-8284.
5. Cairns, J., S. Qin, R. Philp, Y. H. Tan, and G. R. Guy. 1994. Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A. J. Biol. Chem. 269:9176-9183.
6. Chen, J., S. Parsons, and D. L. Brautigan. 1994. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J. Biol. Chem. 269:7957-7962.
7. Chen, R.-H., and R. Derynck. 1994. Homomeric interactions between the type II TGF-β receptors. J. Biol. Chem. 269:22868-22874.
8. Chen, R.-H., P. J. Miettinen, E. M. Maruoka, L. Choy, and R. Derynck. 1995. A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 377:548-552.
9. Clarke, P. R., I. Hoffmann, G. Draetta, and E. Karsenti. 1993. Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol. Biol. Cell 4:397-411.
10. Cohen, P. 1991. Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts. Methods Enzymol. 201:389-397.
11. Derynck, R., and Y. Zhang. 1996. Intracellular signalling: the mad way to do it. Curr. Biol. 6:1226-1229.
12. Derynck, R., and X.-H. Feng. 1997. TGF-β receptor signaling. BBA Rev. Cancer. 1333:F105-F150.
13. Ebner, R., R.-H. Chen, L. Shum. S. Lawler, T. Zioncheck, A. R. Lopez, and R. Derynck. 1993. Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260:1344-1348.
14. Feng, X.-H., E. H. Filvaroff, and R. Derynck. 1995. Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. J. Biol. Chem. 270:24237-24245.
15. Franzén, P., P. ten Dijke, H. Ichijo, H. Yamashita, P. Schulz, C.-H. Heldin, and K. Miyazono. 1993. Cloning of TGF-β type I receptor that forms a heteromeric complex with the TGF-β type I receptor. Cell 75:681-692.
16. Geng, Y., and R. A. Weinberg. 1993. Transforming growth factor β effects on expression of G1 cyclins and eyelin-dependent protein kinases. Proc. Natl. Acad. Sci. USA 90:10315-10319.
17. Goyette, M. C., K. Cho, C. L. Fasching, D. B. Levy, K. W. Kinzler, C. Paraskeva, B. Vogelstein, and E. Stanbridge. 1992. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol. Cell. Biol. 12:1387-1395.
18. Graycar, J. L., D. A. Miller, B. A. Arrick, R. M. Lyons, H. L. Moses, and R. Derynck. 1989. Human transforming growth factor-β3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-βl and -β2. Mol. Endocrinol. 3:1977-1986.
19. Guy, G. R., R. Philp, and Y. H. Tan. 1995. Activation of protein kinases and inactivation of protein phosphatase 2A in tumor necrosis factor and interleukin-1 signal-transduction pathways. Eur. J. Biochem. 229:503-511.
20. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-260.
21. Healy, A. M., S. Zolnierowicz, A. E. Stapleton, M. Goebl, A. A. DePaoli-Roach, and J. R. Pringle. 1991. CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase. Mol. Cell. Biol. 11:5767-5780.
22. Hedman, K., M. Kurkinen, K. Alitalo, A. Vaheri, S. Johansson, and M. Hook. 1979. Isolation of the pericellular matrix of human fibroblast cultures. J. Cell Biol. 81:83-91.
23. Heldin, C.-H. 1996. Protein tyrosine kinase receptors. Cancer Surv. 27:7-24.
24. Heldin, C.-H, K. Miyazono, and P. ten Dijke. 1997. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390:465-471.
25. Kamibayashi, C., R. Estes, R. L. Lickteig, S.-I. Yang, C. Craft, and M. C. Mumby. 1994. Comparison of heterotrimeric protein phosphatase 2A containing different B subunits. J. Biol. Chem. 269:20139-20148.
26. Kato, M., A. Ishizaki, U. Hellman, C. Wernstedt, M. Kyogoku, K. Miyazono, C.-H. Heldin, and K. Funa. 1995. A human keratinocytc cell line produces two autocrine growth inhibitors, transforming growth factor-β and insulin-like growth factor binding protein-6, in a calcium-and cell density-dependent manner. J. Biol. Chem. 270:12373-12379.
27. Keeton, M. R., S. A. Curriden, A.-J. van Zonneveld, and D. J. Loskutoff. 1991. Identification of regulatory sequences in the type I plasminogen activator inhibitor gene responsive to transforming growth factor β. J. Biol. Chem. 266:23048-24052.
28. Lagna, G., A. Hata, A. Hemmati-Brivanlou, and J. Massagué. 1996. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383:832-836.
29. Laiho, M., F. M. B. Weis, and J. Massague. 1990. Concomitant loss of transforming growth factor (TGF)-β receptor types 1 and II in TGF-β-resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265:18518-18524.
30. Laiho, M., F. M. B. Weis, F. T. Boyd, R. A. Ignotz, and J. Massagué. 1991. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J. Biol. Chem. 266:9108-9112.
31. Lin, H. Y., X.-F. Wang, E. Ng-Eaton, R. A. Weinberg, and H. F. Lodish. 1992. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775-785.
32. Liu, F., F. Ventura, J. Doody, and J. Massagué. 1995. Human type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol. Cell. Biol. 15:3479-3486.
33. Massagué, J., A. Hata, and F. Liu. 1997. TGF-β signalling through the Smad pathway. Trends Cell Biol. 7:187-192.
34. Mayer, R. E., P. Hendrix, P. Cron, R. Matthies, S. R. Stone, J. Goris, W. Merlevede, J. Hofsteenge, and B. A. Hemmings. 1991. Structure of the 55kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry 30:3589-3597.
35. Mayer-Jaekel, R. E., H. Ohkura, R. Games, C. E. Sunkel, S. Baumgartner, B. A. Hemmings, and D. M. Glover. 1993. The 55 kd regulatory subunit of drosophila protein phosphatase 2A is required for anaphase. Cell 72:621-633.
36. Mayer-Jaekel, R. E., H. Ohkura, P. Ferrigno, N. Andjelkovic, K. Shiomi, T. Uemura, D. M. Glover, and B. M. Hemmings. 1994. Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J. Cell. Sci. 107: 2609-2616.
37. McCaffrey, T. A., D. J. Falcone, C. F. Brayton, L. A. Agarwal, F. G. Welt, and B. B. Weksler. 1989. Transforming growth factor-β activity is potentiated by heparin via dissociation of the transforming growth factor-β/α2-macroglobulin inactive complex. J. Cell Biol. 109:441-448.
38. McCright, B., and D. M. Virshup. 1995. Identification of a new family of protein phosphatase 2A regulatory subunits. J. Biol. Chem. 270:26123-26128.
39. Miettinen, P. J., R. Ebner, A. R. Lopez, and R. Derynck. 1994. TGF-β-induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 127:2021-2036.
40. Neer, E. J., C. J. Schmidt, R. Nambudripad, and T. F. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature 371:297-300.
41. Reynisdottir, I., K. Polyak, A. Iavarone, and J. Massagué. 1995. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9:1831-1845.
42. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
43. Sontag, E., S. Fedorov, C. Kamibayashi, D. Robbins, M. Cobb, and M. Mumby. 1993. The interaction of SV40 small tumor antigen with protein kinase 2A stimulates the MAP kinase pathway and induces cell proliferation. Cell 75:887-897.
44. Sontag, E., V. Nunbhakdi-Craig, G. S. Bloom, and M. C. Mumby. 1995. Novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. J. Cell Biol. 128:1131-1144.
45. Tanabe, O., T. Nagase, T. Murakami, H. Nozaki, H. Usui, Y. Nishito, H. Hayashi, H. Kagamiyama, and M. Takeda. 1996. Molecular cloning of a 74-kDa regulatory subunit (B″) of human protein phosphatase 2A. FEBS Lett. 379:107-111.
46. Tehrani, M. A., M. C. Mumby, and C. Kamibayashi. 1996. Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J. Biol. Chem. 271:5164-5170.
47. Tehrani, M., and M. Mumby. Unpublished data.
48. Wrana, J. L., L. Attisano, J. Cárcamo, A. Zentella, J. Doody, M. Laiho, X.-F. Wang, and J. Massagué. 1992. TGF-β signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014.
49. Wrana, J. L., L. Attisano, R. Wieser, F. Ventura, and J. Massagué. 1994. Mechanism of activation of the TGF-β receptor. Nature 370:341-347.
50. Zhang, Y., X.-H. Feng, R.-Y. Wu, and R. Detynck. 1996. Receptor-associated Mad homologues synergize to induce TGF-β response. Nature 382:168-172.