Assembly of epithelial tight junctions is negatively regulated by Par6

Current Biology

Volumn 12, Issue 3, 2002, Pages 221-225

  Gao, Lin ^a   Joberty, Gérard ^a   Macara, Ian G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA; METAZOA;

CALCIUM; ISOPROTEIN; PAR 6 PROTEIN; PAR-6 PROTEIN; PROTEIN; PROTEIN CDC42; PROTEIN KINASE C; PROTEIN KINASE C ZETA;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL JUNCTION; CELL LINE; CHEMISTRY; CYTOLOGY; DIFFUSION; DOG; ELECTRON MICROSCOPY; EPITHELIUM CELL; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TIGHT JUNCTION; TIME; ULTRASTRUCTURE;

ADHERENS JUNCTIONS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CDC42 GTP-BINDING PROTEIN; CELL LINE; DIFFUSION; DOGS; EPITHELIAL CELLS; MICE; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TIGHT JUNCTIONS; TIME FACTORS;

EID: 0037022122     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00663-7     Document Type: Article

References (22)

1. Role of tight junctions in establishing and maintaining cell polarity
2. Molecular architecture of tight junctions
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4. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
5. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
6. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
7. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
8. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
9. Occludin: A novel integral membrane protein localizing at tight junctions
10. A functional assay for proteins involved in establishing an epithelial occluding barrier: Identification of a uvomorulin-like polypeptide
11. Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells
12. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
13. SMART: Identification and annotation of domains from signalling and extracellular protein sequences
14. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
15. Rho GTPases and signaling networks
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17. Cadherin engagement regulates Rho family GTPases
18. E-cadherin-mediated cell-cell attachment activates Cdc42
19. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
20. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
21. Junctional adhesion molecule (JAM) binds to PAR-3: A possible mechanism for the recruitment of PAR-3 to tight junctions
22. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)