Porcine Toll-like receptors: The front line of pathogen monitoring and possible implications for disease resistance

Developmental and Comparative Immunology

Volumn 33, Issue 3, 2009, Pages 353-361

  Uenishi, Hirohide ^a,c   Shinkai, Hiroki ^b,c  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b Society for Techno Innovation of Agriculture Forestry and Fisheries   (Japan)

^c Animal Genome Research Program   (Japan)

Author keywords

Breeding; Disease susceptibility; Ligand recognition; Pig; Single nucleotide polymorphisms; Toll like receptor; Vaccine design

Indexed keywords

TOLL LIKE RECEPTOR;

ARTICLE; BREEDING; DISEASE RESISTANCE; GENE FUNCTION; GENE SEQUENCE; LIVESTOCK; NONHUMAN; PATHOGENESIS; PHYLOGENY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE;

MAMMALIA; SUIDAE; SUS;

EID: 57149096236     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2008.06.001     Document Type: Article

References (125)

1. Davis M.M., and Chien Y.-H. T-cell antigen receptors. In: Paul W.E. (Ed). Fundamental immunology (2003), Lippincott Williams & Wilkins, Philadelphia, PA 227-258
2. Max E.E. Immunoglobulins: molecular genetics. In: Paul W.E. (Ed). Fundamental immunology (2003), Lippincott Williams & Wilkins, Philadelphia, PA 107-158
3. Janeway Jr. C.A., and Medzhitov R. Innate immune recognition. Annu Rev Immunol 20 (2002) 197-216
4. Kabelitz D., and Medzhitov R. Innate immunity-cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol 19 (2007) 1-3
5. Rast J.P., Smith L.C., Loza-Coll M., Hibino T., and Litman G.W. Genomic insights into the immune system of the sea urchin. Science 314 (2006) 952-956
6. Zipfel C. Pattern-recognition receptors in plant innate immunity. Curr Opin Immunol 20 (2008) 10-16
7. Ito T., Amakawa R., and Fukuhara S. Roles of Toll-like receptors in natural interferon-producing cells as sensors in immune surveillance. Hum Immunol 63 (2002) 1120-1125
8. Trinchieri G., and Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7 (2007) 179-190
9. Hashimoto C., Hudson K.L., and Anderson K.V. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52 (1988) 269-279
10. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
11. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
12. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
13. Qureshi S.T., Lariviere L., Leveque G., Clermont S., Moore K.J., Gros P., et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189 (1999) 615-625
14. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162 (1999) 3749-3752
15. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 (2005) 1-14
16. Núñez Miguel R., Wong J., Westoll J.F., Brooks H.J., O'Neill L.A., Gay N.J., et al. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS ONE 2 (2007) e788
17. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., and Underhill D.M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 197 (2003) 1107-1117
18. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (2001) 1099-1103
19. Hasan U., Chaffois C., Gaillard C., Saulnier V., Merck E., Tancredi S., et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol 174 (2005) 2942-2950
20. Heil F., Ahmad-Nejad P., Hemmi H., Hochrein H., Ampenberger F., Gellert T., et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol 33 (2003) 2987-2997
21. Matsumoto M., Funami K., Tanabe M., Oshiumi H., Shingai M., Seto Y., et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 171 (2003) 3154-3162
22. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413 (2001) 732-738
23. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3 (2002) 196-200
24. Hergersberg M. Biological aspects of cytosine methylation in eukaryotic cells. Experientia 47 (1991) 1171-1185
25. Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198 (2003) 513-520
26. Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
27. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
28. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 101 (2004) 3516-3521
29. Matsushima N., Tanaka T., Enkhbayar P., Mikami T., Taga M., Yamada K., et al. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate Toll-like receptors. BMC Genom 8 (2007) 124
30. Fujita M., Into T., Yasuda M., Okusawa T., Hamahira S., Kuroki Y., et al. Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans. J Immunol 171 (2003) 3675-3683
31. Sanghavi S.K., Shankarappa R., and Reinhart T.A. Genetic analysis of Toll/interleukin-1 receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Immunogenetics 56 (2004) 667-674
32. Nishiya T., and DeFranco A.L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 279 (2004) 19008-19017
33. O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 (2007) 353-364
34. Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J Exp Med 201 (2005) 915-923
35. Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167 (2001) 5887-5894
36. Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J Immunol 169 (2002) 6668-6672
37. Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D., et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 102 (2005) 9577-9582
38. Kajava A.V. Structural diversity of leucine-rich repeat proteins. J Mol Biol 277 (1998) 519-527
39. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci USA 97 (2000) 13766-13771
40. Zhou H., Gu J., Lamont S.J., and Gu X. Evolutionary analysis for functional divergence of the Toll-like receptor gene family and altered functional constraints. J Mol Evol 65 (2007) 119-123
41. Zhang D., Zhang G., Hayden M.S., Greenblatt M.B., Bussey C., Flavell R.A., et al. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 303 (2004) 1522-1526
42. Werling D., and Coffey T.J. Pattern recognition receptors in companion and farm animals-the key to unlocking the door to animal disease?. Vet J 174 (2007) 240-251
43. Alvarez B., Revilla C., Chamorro S., Lopez-Fraga M., Alonso F., Dominguez J., et al. Molecular cloning, characterization and tissue expression of porcine Toll-like receptor 4. Dev Comp Immunol 30 (2006) 345-355
44. Alves M.P., Neuhaus V., Guzylack-Piriou L., Ruggli N., McCullough K.C., and Summerfield A. Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets. Gene Ther 14 (2007) 836-844
45. Moue M., Tohno M., Shimazu T., Kido T., Aso H., Saito T., et al. Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line. Biochim Biophys Acta 1780 (2008) 134-144
46. Muneta Y., Uenishi H., Kikuma R., Yoshihara K., Shimoji Y., Yamamoto R., et al. Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. J Interferon Cytokine Res 23 (2003) 583-590
47. Shimosato T., Kitazawa H., Katoh S., Tomioka Y., Karima R., Ueha S., et al. Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant. Biochim Biophys Acta 1627 (2003) 56-61
48. Shinkai H., Muneta Y., Suzuki K., Eguchi-Ogawa T., Awata T., and Uenishi H. Porcine Toll-like receptor 1, 6, and 10 genes: complete sequencing of genomic region and expression analysis. Mol Immunol 43 (2006) 1474-1480
49. Shinkai H., Tanaka M., Morozumi T., Eguchi-Ogawa T., Okumura N., Muneta Y., et al. Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes. Immunogenetics 58 (2006) 324-330
50. Thomas A.V., Broers A.D., Vandegaart H.F., and Desmecht D.J. Genomic structure, promoter analysis and expression of the porcine (Sus scrofa) TLR4 gene. Mol Immunol 43 (2006) 653-659
51. Tohno M., Shimazu T., Aso H., Kawai Y., Saito T., and Kitazawa H. Molecular cloning and functional characterization of porcine MyD88 essential for TLR signaling. Cell Mol Immunol 4 (2007) 369-376
52. Qiu X.T., Li Y.H., Li H., Yu Y., and Zhang Q. Molecular cloning, mapping, and tissue expression of the porcine cluster of differentiation 14 (CD14) gene. Biochem Genet 45 (2007) 459-468
53. Hasslung F.C., Berg M., Allan G.M., Meehan B.M., McNeilly F., and Fossum C. Identification of a sequence from the genome of porcine circovirus type 2 with an inhibitory effect on IFN-α production by porcine PBMCs. J Gen Virol 84 (2003) 2937-2945
54. Vincent I.E., Balmelli C., Meehan B., Allan G., Summerfield A., and McCullough K.C. Silencing of natural interferon producing cell activation by porcine circovirus type 2 DNA. Immunology 120 (2007) 47-56
55. Wikström F.H., Meehan B.M., Berg M., Timmusk S., Elving J., Fuxler L., et al. Structure-dependent modulation of alpha interferon production by porcine circovirus 2 oligodeoxyribonucleotide and CpG DNAs in porcine peripheral blood mononuclear cells. J Virol 81 (2007) 4919-4927
56. Loving C.L., Brockmeier S.L., Ma W., Richt J.A., and Sacco R.E. Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA. J Immunol 177 (2006) 8432-8439
57. McGuire K., Jones M., Werling D., Williams J.L., Glass E.J., and Jann O. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. Anim Genet 37 (2006) 47-50
58. Menzies M., and Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Vet Immunol Immunopathol 109 (2006) 23-30
59. Opsal M.A., Våge D.I., Hayes B., Berget I., and Lien S. Genomic organization and transcript profiling of the bovine Toll-like receptor gene cluster TLR6-TLR1-TLR10. Gene 384 (2006) 45-50
60. Goldammer T., Zerbe H., Molenaar A., Schuberth H.J., Brunner R.M., Kata S.R., et al. Mastitis increases mammary mRNA abundance of β-defensin 5, Toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clin Diagn Lab Immunol 11 (2004) 174-185
61. Yang W., Molenaar A., Kurts-Ebert B., and Seyfert H.M. NF-κB factors are essential, but not the switch, for pathogen-related induction of the bovine β-defensin 5-encoding gene in mammary epithelial cells. Mol Immunol 43 (2006) 210-225
62. De Schepper S., De Ketelaere A., Bannerman D.D., Paape M.J., Peelman L., and Burvenich C. The Toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. Vet Res 39 (2008) 5
63. Fukui A., Inoue N., Matsumoto M., Nomura M., Yamada K., Matsuda Y., et al. Molecular cloning and functional characterization of chicken Toll-like receptors. A single chicken Toll covers multiple molecular patterns. J Biol Chem 276 (2001) 47143-47149
64. Keestra A.M., de Zoete M.R., van Aubel R.A., and van Putten J.P. The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2. J Immunol 178 (2007) 7110-7119
65. Temperley N.D., Berlin S., Paton I.R., Griffin D.K., and Burt D.W. Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss. BMC Genom 9 (2008) 62
66. Higgs R., Cormican P., Cahalane S., Allan B., Lloyd A.T., Meade K., et al. Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Infect Immun 74 (2006) 1692-1698
67. Leveque G., Forgetta V., Morroll S., Smith A.L., Bumstead N., Barrow P., et al. Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickens. Infect Immun 71 (2003) 1116-11124
68. Iqbal M., Philbin V.J., Withanage G.S., Wigley P., Beal R.K., Goodchild M.J., et al. Identification and functional characterization of chicken Toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar Typhimurium. Infect Immun 73 (2005) 2344-2350
69. Higuchi M., Matsuo A., Shingai M., Shida K., Ishii A., Funami K., et al. Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily. Dev Comp Immunol 32 (2008) 147-155
70. Smirnova I., Hamblin M.T., McBride C., Beutler B., and Di Rienzo A. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics 158 (2001) 1657-1664
71. Arbour N.C., Lorenz E., Schutte B.C., Zabner J., Kline J.N., Jones M., et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25 (2000) 187-191
72. Barber R.C., Aragaki C.C., Rivera-Chavez F.A., Purdue G.F., Hunt J.L., and Horton J.W. TLR4 and TNF-α polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet 41 (2004) 808-813
73. Franchimont D., Vermeire S., El Housni H., PierikM, Van Steen K., Gustot T., et al. Deficient host-bacteria interactions in inflammatory bowel disease? The Toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 53 (2004) 987-992
74. Hawn T.R., Verbon A., Janer M., Zhao L.P., Beutler B., and Aderem A. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci USA 102 (2005) 2487-2489
75. Kiechl S., Lorenz E., Reindl M., Wiedermann C.J., Oberhollenzer F., Bonora E., et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347 (2002) 185-192
76. Bochud P.Y., Hawn T.R., and Aderem A. Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol 170 (2003) 3451-3454
77. Kang T.J., and Chae G.T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 31 (2001) 53-58
78. Lorenz E., Mira J.P., Cornish K.L., Arbour N.C., and Schwartz D.A. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 68 (2000) 6398-6401
79. Ogus A.C., Yoldas B., Ozdemir T., Uguz A., Olcen S., Keser I., et al. The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 23 (2004) 219-223
80. Bochud P.Y., Hersberger M., Taffe P., Bochud M., Stein C.M., Rodrigues S.D., et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS 21 (2007) 441-446
81. Hawn T.R., Misch E.A., Dunstan S.J., Thwaites G.E., Lan N.T., Quy H.T., et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol 37 (2007) 2280-2289
82. He J.F., Jia W.H., Fan Q., Zhou X.X., Qin H.D., Shugart Y.Y., et al. Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population. BMC Cancer 7 (2007) 194
83. Kesh S, Mensah NY, Peterlongo P, Jaffe D, Hsu K, VDB M, et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann NY Acad Sci 2005;1062:95-103.
84. Lazarus R., Klimecki W.T., Raby B.A., Vercelli D., Palmer L.J., Kwiatkowski D.J., et al. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three US ethnic groups and exploratory case-control disease association studies. Genomics 81 (2003) 85-91
85. Novak N., Yu C.F., Bussmann C., Maintz L., Peng W.M., Hart J., et al. Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy 62 (2007) 766-772
86. Omueti K.O., Mazur D.J., Thompson K.S., Lyle E.A., and Tapping R.I. The polymorphism P315L of human Toll-like receptor 1 impairs innate immune sensing of microbial cell wall components. J Immunol 178 (2007) 6387-6394
87. Hawn T.R., Verbon A., Lettinga K.D., Zhao L.P., Li S.S., Laws R.J., et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires' disease. J Exp Med 198 (2003) 1563-1572
88. Gewirtz A.T., Vijay-Kumar M., Brant S.R., Duerr R.H., Nicolae D.L., and Cho J.H. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1157-G1163
89. Ma X., Liu Y., Gowen B.B., Graviss E.A., Clark A.G., and Musser J.M. Full-exon resequencing reveals Toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE 2 (2007) e1318
90. White S.N., Taylor K.H., Abbey C.A., Gill C.A., and Womack J.E. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proc Natl Acad Sci USA 100 (2003) 10364-10369
91. Cargill E.J., and Womack J.E. Detection of polymorphisms in bovine Toll-like receptors 3, 7, 8, and 9. Genomics 89 (2007) 745-755
92. Seabury C.M., Cargill E.J., and Womack J.E. Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10. Genomics 90 (2007) 502-515
93. Zhou H., Hickford J.G., Fang Q., and Lin Y.S. Allelic variation of the ovine Toll-like receptor 4 gene. Dev Comp Immunol 31 (2007) 105-108
94. Zhou H., and Hickford J.G. Polymorphism of Toll-like receptor 9 (TLR9) gene in sheep. Vet Immunol Immunopathol 121 (2008) 140-143
95. Ye X., Avendano S., Dekkers J.C., and Lamont S.J. Association of twelve immune-related genes with performance of three broiler lines in two different hygiene environments. Poult Sci 85 (2006) 1555-1569
96. Grabiec A., Meng G., Fichte S., Bessler W., Wagner H., and Kirschning C.J. Human but not murine Toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides. J Biol Chem 279 (2004) 48004-48012
97. Spiller S., Dreher S., Meng G., Grabiec A., Thomas W., Hartung T., et al. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282 (2007) 13190-13198
98. Jin M.S., Kim S.E., Heo J.Y., Lee M.E., Kim H.M., Paik S.G., et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 (2007) 1071-1082
99. Meng G., Grabiec A., Vallon M., Ebe B., Hampel S., Bessler W., et al. Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. J Biol Chem 278 (2003) 39822-39829
100. Kruithof E.K., Satta N., Liu J.W., Dunoyer-Geindre S., and Fish R.J. Gene conversion limits divergence of mammalian TLR1 and TLR6. BMC Evol Biol 7 (2007) 148
101. Viriyakosol S., Tobias P.S., Kitchens R.L., and Kirkland T.N. MD-2 binds to bacterial lipopolysaccharide. J Biol Chem 276 (2001) 38044-38051
102. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 (1999) 1777-1782
103. Kim H.M., Park B.S., Kim J.I., Kim S.E., Lee J., Oh S.C., et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130 (2007) 906-917
104. Edfors-Lilja I., Gustafsson U., Duval-Iflah Y., Ellergren H., Johansson M., Juneja R.K., et al. The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen. Anim Genet 26 (1995) 237-242
105. Edfors-Lilja I., Wattrang E., Marklund L., Moller M., Andersson-Eklund L., Andersson L., et al. Mapping quantitative trait loci for immune capacity in the pig. J Immunol 161 (1998) 829-835
106. Jørgensen C.B., Cirera S., Anderson S.I., Archibald A.L., Raudsepp T., Chowdhary B., et al. Linkage and comparative mapping of the locus controlling susceptibility towards E. coli F4ab/ac diarrhoea in pigs. Cytogenet Genome Res 102 (2003) 157-162
107. Reiner G., Kliemt D., Willems H., Berge T., Fischer R., Köhler F., et al. Mapping of quantitative trait loci affecting resistance/susceptibility to Sarcocystis miescheriana in swine. Genomics 89 (2007) 638-646
108. Reiner G., Melchinger E., Kramarova M., Pfaff E., Büttner M., Saalmüller A., et al. Detection of quantitative trait loci for resistance/susceptibility to pseudorabies virus in swine. J Gen Virol 83 (2002) 167-172
109. Wattrang E., Almqvist M., Johansson A., Fossum C., Wallgren P., Pielberg G., et al. Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte function. Anim Genet 36 (2005) 337-345
110. Rharbaoui F., Drabner B., Borsutzky S., Winckler U., Morr M., Ensoli B., et al. The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant. Eur J Immunol 32 (2002) 2857-2865
111. Didierlaurent A., Ferrero I., Otten L.A., Dubois B., Reinhardt M., Carlsen H., et al. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol 172 (2004) 6922-6930
112. Ben-Yedidia T., and Arnon R. Towards an epitope-based human vaccine for influenza. Hum Vaccin 1 (2005) 95-101
113. Honko A.N., Sriranganathan N., Lees C.J., and Mizel S.B. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun 74 (2006) 1113-1120
114. + T cells in vivo. J Immunol 169 (2002) 3914-3919
115. Huleatt J.W., Jacobs A.R., Tang J., Desai P., Kopp E.B., Huang Y., et al. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 25 (2007) 763-775
116. Loots K., Revets H., and Goddeeris B.M. Attachment of the outer membrane lipoprotein (OprI) of Pseudomonas aeruginosa to the mucosal surfaces of the respiratory and digestive tract of chickens. Vaccine 26 (2008) 546-551
117. Gorodkin J., Cirera S., Hedegaard J., Gilchrist M.J., Panitz F., Jørgensen C., et al. Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Genome Biol 8 (2007) R45
118. Humphray S.J., Scott C.E., Clark R., Marron B., Bender C., Camm N., et al. A high utility integrated map of the pig genome. Genome Biol 8 (2007) R139
119. Schook L.B., Beever J.E., Rogers J., Humphray S., Archibald A., Chardon P., et al. Swine Genome Sequencing Consortium (SGSC): a strategic roadmap for sequencing the pig genome. Comp Func Genom 6 (2005) 251-255
120. Uenishi H., Eguchi-Ogawa T., Shinkai H., Okumura N., Suzuki K., Toki D., et al. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Nucleic Acids Res 35 (2007) D650-D653
121. Bentley D.R. Whole-genome re-sequencing. Curr Opin Genet Dev 16 (2006) 545-552
122. Sherry S.T., Ward M.H., Kholodov M., Baker J., Phan L., Smigielski E.M., et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29 (2001) 308-311
123. Letunic I., Copley R.R., Pils B., Pinkert S., Schultz J., and Bork P. SMART 5: domains in the context of genomes and networks. Nucleic Acids Res 34 (2006) D257-D260
124. Willing B.P., and Van Kessel A.G. Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig. J Anim Sci 85 (2007) 3256-3266
125. Burkey T.E., Skjolaas K.A., Dritz S.S., and Minton J.E. Expression of Toll-like receptors, interleukin 8, macrophage migration inhibitory factor, and osteopontin in tissues from pigs challenged with Salmonella enterica serovar Typhimurium or serovar Choleraesuis. Vet Immunol Immunopathol 115 (2007) 309-319