Pattern recognition receptors in companion and farm animals - The key to unlocking the door to animal disease?

Veterinary Journal

Volumn 174, Issue 2, 2007, Pages 240-251

  Werling, Dirk ^a   Coffey, Tracey J ^b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

Immune system; Innate; Pattern recognition; Receptors; Signalling pathways

Indexed keywords

DECTIN 1; DECTIN 2; DECTIN 205; LEPTIN RECEPTOR C; MACROPHAGE MANNOSE RECEPTOR; MEMBRANE RECEPTOR; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL DISEASE; ANTIGEN RECOGNITION; BOVIDS; CARNIVORE; CHICKEN; DOMESTIC ANIMAL; FARM ANIMAL; HORSE; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOSTIMULATION; INNATE IMMUNITY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SWINE; VETERINARY MEDICINE;

ANIMALS; ANIMALS, DOMESTIC; IMMUNE SYSTEM; IMMUNITY, NATURAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, IMMUNOLOGICAL; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TOLL-LIKE RECEPTORS;

ANIMALIA; MURINAE;

EID: 34548780733     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2006.10.010     Document Type: Review

References (82)

1. Abujamra A.L., Spanjaard R.A., Akinsheye I., Zhao X., Faller D.V., and Ghosh S.K. Leukemia virus long terminal repeat activates NFκB pathway by a TLR3-dependent mechanism. Virology 345 (2006) 390-403
2. Alvarez B., Revilla C., Chamorro S., Lopez-Fraga M., Alonso F., Dominguez J., and Ezquerra A. Molecular cloning, characterization and tissue expression of porcine Toll-like receptor 4. Developmental and Comparative Immunology 30 (2006) 345-355
3. Anderson K.V., Bokla L., and Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42 (1985) 791-798
4. Anderson K.V., Jurgens G., and Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42 (1985) 779-789
5. Arrighi J.F., Pion M., Garcia E., Escola J.M., van Kooyk Y., Geijtenbeek T.B., and Piguet V. DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. Journal of Experimental Medicine 200 (2004) 1279-1288
6. Asahina Y., Yoshioka N., Kano R., Moritomo T., and Hasegawa A. Full-length cDNA cloning of Toll-like receptor 4 in dogs and cats. Veterinary Immunology and Immunopathology 96 (2003) 159-167
7. Bazzocchi C., Mortarino M., Comazzi S., Bandi C., Franceschi A., and Genchi C. Expression and function of Toll-like receptor 2 in canine blood phagocytes. Veterinary Immunology and Immunopathology 104 (2005) 15-19
8. Bergman M.P., Engering A., Smits H.H., van Vliet S.J., van Bodegraven A.A., Wirth H.P., Kapsenberg M.L., Vandenbroucke-Grauls C.M., van Kooyk Y., and Appelmelk B.J. Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. Journal of Experimental Medicine 200 (2004) 979-990
9. Beutler B., and Rehli M. Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. Current Topics in Microbiology and Immunology 270 (2002) 1-21
10. Bonkobara M., Hoshino M., Yagihara H., Tamura K., Isotani M., Tanaka Y., Washizu T., and Ariizumi K. Identification and gene expression of bovine C-type lectin dectin-2. Veterinary Immunology and Immunopathology 110 (2006) 179-186
11. Boyd B.L., Lee T.M., Kruger E.F., and Pinchuk L.M. Cytopathic and non-cytopathic bovine viral diarrhoea virus biotypes affect fluid phase uptake and mannose receptor-mediated endocytosis in bovine monocytes. Veterinary Immunology and Immunopathology 102 (2004) 53-65
12. Cambi A., Koopman M., and Figdor C.G. How C-type lectins detect pathogens. Cellular Microbiology 7 (2005) 481-488
13. Creagh E.M., and O'Neill L.A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends in Immunology 27 (2006) 352-357
14. Del Vecchio F., Mbow L., and Sarisky R.T. Novel treatment options for infectious exacerbations. Drug Discovery Today 10 (2005) 1500-1502
15. Dil N., and Qureshi M.A. Differential expression of inducible nitric oxide synthase is associated with differential Toll-like receptor-4 expression in chicken macrophages from different genetic backgrounds. Veterinary Immunology and Immunopathology 84 (2002) 191-207
16. Dil N., and Qureshi M.A. Involvement of lipopolysaccharide related receptors and nuclear factor κB in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds. Veterinary Immunology and Immunopathology 88 (2002) 149-161
17. Drickamer K. Two distinct classes of carbohydrate-recognition domains in animal lectins. Journal of Biological Chemistry 263 (1988) 9557-9560
18. Eicher S.D., McMunn K.A., Hammon H.M., and Donkin S.S. Toll-like receptors 2 and 4, and acute phase cytokine gene expression in dexamethasone and growth hormone treated dairy calves. Veterinary Immunology and Immunopathology 98 (2004) 115-125
19. Farnell M.B., Crippen T.L., He H., Swaggerty C.L., and Kogut M.H. Oxidative burst mediated by toll like receptors (TLR) and CD14 on avian heterophils stimulated with bacterial toll agonists. Developmental and Comparative Immunology 27 (2003) 423-429
20. Farnell M.B., He H., Genovese K., and Kogut M.H. Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist. International Immunopharmacology 3 (2003) 1677-1684
21. Farnell M.B., He H., and Kogut M.H. Differential activation of signal transduction pathways mediating oxidative burst by chicken heterophils in response to stimulation with lipopolysaccharide and lipoteichoic acid. Inflammation 27 (2003) 225-231
22. Franchini M., Schweizer M., Matzener P., Magkouras I., Sauter K.S., Mirkovitch J., Peterhans E., and Jungi T.W. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Veterinary Immunology and Immunopathology 110 (2006) 37-49
23. Galindo I., Almazan F., Bustos M.J., Vinuela E., and Carrascosa A.L. African swine fever virus EP153R open reading frame encodes a glycoprotein involved in the hemadsorption of infected cells. Virology 266 (2000) 340-351
24. Gliddon D.R., Hope J.C., Brooke G.P., and Howard C.J. DEC-205 expression on migrating dendritic cells in afferent lymph. Immunology 111 (2004) 262-272
25. Goldammer T., Zerbe H., Molenaar A., Schuberth H.J., Brunner R.M., Kata S.R., and Seyfert H.M. Mastitis increases mammary mRNA abundance of β-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clinical and Diagnostic Laboratory Immunology 11 (2004) 174-185
26. Gordon S. The role of the macrophage in immune regulation. Research in Immunology 149 (1998) 685-688
27. Griebel P.J., Brownlie R., Manuja A., Nichani A., Mookherjee N., Popowych Y., Mutwiri G., Hecker R., and Babiuk L.A. Bovine Toll-like receptor 9: a comparative analysis of molecular structure, function and expression. Veterinary Immunology and Immunopathology 108 (2005) 11-16
28. Haga I.R., and Bowie A.G. Evasion of innate immunity by vaccinia virus. Parasitology 130 Suppl. (2005) S11-S25
29. Hamburger Z.A., Brown M.S., Isberg R.R., and Bjorkman P.J. Crystal structure of invasin: a bacterial integrin-binding protein. Science 286 (1999) 291-295
30. Hashimoto M., Asahina Y., Sano J., Kano R., Moritomo T., and Hasegawa A. Cloning of canine Toll-like receptor 9 and its expression in dog tissues. Veterinary Immunology and Immunopathology 106 (2005) 159-163
31. He H., Genovese K.J., Nisbet D.J., and Kogut M.H. Profile of Toll-like receptor expressions and induction of nitric oxide synthesis by Toll-like receptor agonists in chicken monocytes. Molecular Immunology 43 (2006) 783-789
32. Heesemann J., Sing A., and Trulzsch K. Yersinia's stratagem: targeting innate and adaptive immune defense. Current Opinion in Microbiology 9 (2006) 55-61
33. Herath S., Fischer D.P., Werling D., Williams E.J., Lilly S.T., Dobson H., Bryant C.E., and Sheldon I.M. Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology 147 (2006) 562-570
34. Higgs R., Cormican P., Cahalane S., Allan B., Lloyd A.T., Meade K., James T., Lynn D.J., Babiuk L.A., and O'Farrelly C. Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Infection and Immunity 74 (2006) 1692-1698
35. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., and Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Journal of Immunology 168 (2002) 4531-4537
36. + T cells. Immunology 88 (1996) 558-564
37. Ignacio G., Nordone S., Howard K.E., and Dean G.A. Toll-like receptor expression in feline lymphoid tissues. Veterinary Immunology and Immunopathology 106 (2005) 229-237
38. Ii M., Matsunaga N., Hazeki K., Nakamura K., Takashima K., Seya T., Hazeki O., Kitazaki T., and Iizawa Y. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Molecular Pharmacology 69 (2006) 1288-1295
39. Ishii M., Hashimoto M., Oguma K., Kano R., Moritomo T., and Hasegawa A. Molecular cloning and tissue expression of canine Toll-like receptor 2 (TLR2). Veterinary Immunology and Immunopathology 110 (2006) 87-95
40. Jiang W., Swiggard W.J., Heufler C., Peng M., Mirza A., Steinman R.M., and Nussenzweig M.C. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375 (1995) 151-155
41. Kelley J., Walter L., and Trowsdale J. Comparative genomics of natural killer cell receptor gene clusters. PLoS Genetics 1 (2005) 129-139
42. Kogut M.H., He H., and Kaiser P. Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells. Animal Biotechnology 16 (2005) 165-181
43. Kogut M.H., Iqbal M., He H., Philbin V., Kaiser P., and Smith A. Expression and function of Toll-like receptors in chicken heterophils. Developmental and Comparative Immunology 29 (2005) 791-807
44. Legarda D., Klein-Patel M.E., Yim S., Yuk M.H., and Diamond G. Suppression of NF-κB-mediated β-defensin gene expression in the mammalian airway by the Bordetella type III secretion system. Cellular Microbiology 7 (2005) 489-497
45. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
46. Leveque G., Forgetta V., Morroll S., Smith A.L., Bumstead N., Barrow P., Loredo-Osti J.C., Morgan K., and Malo D. Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickens. Infection and Immunity 71 (2003) 1116-1124
47. Lew D.B., Songu-Mize E., Pontow S.E., Stahl P.D., and Rattazzi M.C. A mannose receptor mediates mannosyl-rich glycoprotein-induced mitogenesis in bovine airway smooth muscle cells. Journal of Clinical Investigation 94 (1994) 1855-1863
48. Linehan S.A., Martinez-Pomares L., and Gordon S. Macrophage lectins in host defence. Microbes and Infection 2 (2000) 279-288
49. Luo Y., Frey E.A., Pfuetzner R.A., Creagh A.L., Knoechel D.G., Haynes C.A., Finlay B.B., and Strynadka N.C. Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Nature 405 (2000) 1073-1077
50. Malek M., Hasenstein J.R., and Lamont S.J. Analysis of chicken TLR4, CD28, MIF, MD-2, and LITAF genes in a Salmonella enteritidis resource population. Poultry Science 83 (2004) 544-549
51. Mbow M.L., and Sarisky R.T. Modulating Toll-like receptor signalling as a novel antiinfective approach. Drug News Perspectives 18 (2005) 179-184
52. McGuire K., Jones M., Werling D., Williams J.L., Glass E.J., and Jann O. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. Animal Genetics 37 (2006) 47-50
53. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
54. Menzies M., and Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Veterinary Immunology and Immunopathology 109 (2006) 23-30
55. Muneta Y., Uenishi H., Kikuma R., Yoshihara K., Shimoji Y., Yamamoto R., Hamashima N., Yokomizo Y., and Mori Y. Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. Journal of Interferon and Cytokine Research 23 (2003) 583-590
56. Murciano C., Villamon E., O'Connor J.E., Gozalbo D., and Gil M.L. Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells. Infection and Immunity 74 (2006) 1403-1406
57. O'Neill L.A. How Toll-like receptors signal: what we know and what we don't know. Current Opinion in Immunology 18 (2006) 3-9
58. Raymond C.R., and Wilkie B.N. Toll-like receptor, MHC II, B7 and cytokine expression by porcine monocytes and monocyte-derived dendritic cells in response to microbial pathogen-associated molecular patterns. Veterinary Immunology and Immunopathology 107 (2005) 235-247
59. Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A., Ryazankina O.I., Gutorov V.V., and Kotwal G.J. The genomic sequence analysis of the left and right species-specific terminal region of a cowpox virus strain reveals unique sequences and a cluster of intact ORFs for immunomodulatory and host range proteins. Virology 243 (1998) 432-460
60. Shinkai H., Muneta Y., Suzuki K., Eguchi-Ogawa T., Awata T., and Uenishi H. Porcine Toll-like receptor 1, 6, and 10 genes: complete sequencing of genomic region and expression analysis. Molecular Immunology 43 (2006) 1474-1480
61. Stein P.E., Boodhoo A., Armstrong G.D., Cockle S.A., Klein M.H., and Read R.J. The crystal structure of pertussis toxin. Structure 2 (1994) 45-57
62. Strandberg Y., Gray C., Vuocolo T., Donaldson L., Broadway M., and Tellam R. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine 31 (2005) 72-86
63. Taylor P.R., Brown G.D., Reid D.M., Willment J.A., Martinez-Pomares L., Gordon S., and Wong S.Y. The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. Journal of Immunology 169 (2002) 3876-3882
64. Thomas A.V., Broers A.D., Vandegaart H.F., and Desmecht D.J. Genomic structure, promoter analysis and expression of the porcine (Sus scrofa) TLR4 gene. Molecular Immunology 43 (2006) 653-659
65. Trowsdale J., Barten R., Haude A., Stewart C.A., Beck S., and Wilson M.J. The genomic context of natural killer receptor extended gene families. Immunological Review 181 (2001) 20-38
66. Underhill D.M. Toll-like receptors: networking for success. European Journal of Immunology 33 (2003) 1767-1775
67. Vychodilova-Krenkova L., Matiasovic J., and Horin P. Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14, TLR4, Cε, and Fcε R1 alpha. International Journal of Immunogenetics 32 (2005) 277-283
68. Wang Q.C., Feng Z.H., Nie Q.H., and Zhou Y.X. DC-SIGN: binding receptors for hepatitis C virus. Chinese Medical Journal 117 (2004) 1395-1400
69. Wassef A., Janardhan K., Pearce J.W., and Singh B. Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle. Histology and Histopathology 19 (2004) 1201-1208
70. Werling D., Hope J.C., Chaplin P., Collins R.A., Taylor G., and Howard C.J. Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells. Journal of Leukocyte Biology 66 (1999) 50-58
71. Werling D., Hope J.C., Howard C.J., and Jungi T.W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology 111 (2004) 41-52
72. Werling D., and Jungi T.W. Toll-like receptors linking innate and adaptive immune response. Veterinary Immunology and Immunopathology 91 (2003) 1-12
73. Werling D., Piercy J., and Coffey T.C. Expression of Toll-like receptors (TLR) on bovine antigen presenting cells - evidence for pathogen discrimination. Veterinary Immunology and Immunopathology 112 (2006) 2-11
74. Werners A.H., Bull S., Vendrig J.C., Smyth T., Bosch R.R., Fink-Gremmels J., and Bryant C.E. Genotyping of Toll-like receptor 4, myeloid differentiation factor 2 and CD-14 in the horse: an investigation into the influence of genetic polymorphisms on the LPS induced TNF-alpha response in equine whole blood. Veterinary Immunology Immunopathology 111 3-4 (2006) 165-173
75. White S.N., Kata S.R., and Womack J.E. Comparative fine maps of bovine Toll-like receptor 4 and Toll-like receptor 2 regions. Mammalian Genome 14 (2003) 149-155
76. White S.N., Taylor K.H., Abbey C.A., Gill C.A., and Womack J.E. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proceedings of the National Academy of Science USA 100 (2003) 10364-10369
77. Willcocks S., Yamakawa Y., Stalker A., Coffey T.J., Goldammer T., and Werling D. Identification and gene expression of the bovine C-type lectin Dectin-1. Veterinary Immunology and Immunopathology 113 (2006) 234-242
78. Willment J.A., Lin H.H., Reid D.M., Taylor P.R., Williams D.L., Wong S.Y., Gordon S., and Brown G.D. Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. Journal of Immunology 171 (2003) 4569-4573
79. Yang W., Molenaar A., Kurts-Ebert B., and Seyfert H.M. NF-κB factors are essential, but not the switch, for pathogen-related induction of the bovine β-defensin 5-encoding gene in mammary epithelial cells. Molecular Immunology 43 (2006) 210-225
80. Yang Z.Y., Huang Y., Ganesh L., Leung K., Kong W.P., Schwartz O., Subbarao K., and Nabel G.J. pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. Journal of Virology 78 (2004) 5642-5650
81. Zelensky A.N., and Gready J.E. The C-type lectin-like domain superfamily. FEBS Journal 272 (2005) 6179-6217
82. Zhang Z., Bashiruddin J.B., Doel C., Horsington J., Durand S., and Alexandersen S. Cytokine and Toll-like receptor mRNAs in the nasal-associated lymphoid tissues of cattle during foot-and-mouth disease virus infection. Journal of Comparative Pathology 134 (2006) 56-62