Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar typhimurium infection in chickens

Infection and Immunity

Volumn 71, Issue 3, 2003, Pages 1116-1124

  Leveque, Gary ^a   Forgetta, Vincenzo ^a   Morroll, Shaun ^b   Smith, Adrian L ^b   Bumstead, Nat ^b   Barrow, Paul ^b   Loredo Osti, J C ^a   Morgan, Kenneth ^a   Malo, Danielle ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^c MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; MEMBRANE PROTEIN; TENASCIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; CHICKEN; GENE LOCUS; GENE MAPPING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; IMMUNE SYSTEM; INFECTION RESISTANCE; INFECTION SENSITIVITY; LINKAGE ANALYSIS; MICROCHROMOSOME; MOLECULAR CLONING; MOLECULAR PROBE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA ENTERICA; SALMONELLOSIS; SEROTYPE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CHICKENS; CHROMOSOME MAPPING; DROSOPHILA PROTEINS; GENETIC PREDISPOSITION TO DISEASE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; POULTRY DISEASES; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; VARIATION (GENETICS);

EID: 0037371395     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.3.1116-1124.2003     Document Type: Article

References (32)

1. Arbour, N. C., E. Lorenz, B. C. Schutte, J. Zabner, J. N. Kline, M. Jones, K. Frees, J. L. Watt, and D. A. Schwartz. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25:187-191.
2. Barrow, P. A., M. B. Huggins, M. A. Lovell, and J. M. Simpson. 1987. Observations on the pathogenesis of experimental Salmonella typhimurium infection in chickens. Res. Vet. Sci. 42:194-199.
3. Bihl, F., L. Lariviere, S. T. Qureshi, L. Flaherty, and D. Malo. 2001. LPShyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4. Genes Immun. 2:56-59.
4. Boyd, Y., M. Goodchild, S. Morroll, and N. Bumstead. 2001. Mapping of the chicken and mouse genes for Toll-like receptor 2 (TLR2) to an evolutionarily conserved chromosomal segment. Immunogenetics 52:294-298.
5. Bumstead, N., and P. Barrow. 1993. Resistance to Salmonella gallinarum, S. pullorum, and S. enteritidis in inbred lines of chickens. Avian Dis. 37:189-193.
6. Bumstead, N., and P. A. Barrow. 1988. Genetics of resistance to Salmonella typhimurium in newly hatched chicks. Br. Poult. Sci. 29:521-529.
7. Crittenden, L. B., L. Provencher, L. Santangello, I. Levin, H. Abplanalp, R. W. Briles, W. E. Briles, and J. B. Dodgson. 1993. Characterization of a red jungle fowl by white leghorn backcross reference population for molecular mapping of the chicken genome. Poult. Sci. 72:334-348.
8. Dekkers, J. C., and F. Hospital. 2002. The use of molecular genetics in the improvement of agricultural populations. Nat. Rev. Genet. 3:22-32.
9. Dil, N., and M. A. Qureshi. 2002. Differential expression of inducible nitric oxide synthase is associated with differential Toll-like receptor-4 expression in chicken macrophages from different genetic backgrounds. Vet. Immunol. Immunopathol, 84:191-207.
10. Fukui, A., N. Inoue, M. Matsumoto, M. Nomura, K. Yamada, Y. Matsuda, K. Toyoshima, and T. Seya. 2001. Molecular cloning and functional characterization of chicken toll-like receptors: a single chicken toll covers multiple molecular patterns. J. Biol. Chem. 276:47143-47149.
11. Gruenheid, S., and P. Gros. 2000. Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport. Curr. Opin. Microbiol. 3:43-48.
12. Hu, J., N. Bumstead, P. Barrow, G. Sebastiani, L. Olien, K. Morgan, and D. Malo. 1997. Resistance to salmonellosis in the chicken is linked to NRAMP1 and TNC. Genome Res. 7:693-704.
13. Hu, J., N. Bumstead, D. Burke, F. A. Ponce de Leon, E. Skamene, P. Gros, and D. Malo. 1995. Genetic and physical mapping of the natural resistanceassociated macrophage protein 1 (NRAMP1) in chicken. Mamm. Genome 6:809-815.
14. Ihaka, R., and R. Gentleman. 1996. R: a language for data analysis and graphics. J. Comput. Graph. Stat. 5:299-314.
15. Kalbfleish, J., and R. L. Prentice. 1980. The statistical analysis of failure time data. Wiley Interscience, New York, N.Y.
16. Manly, K. F. 1993. A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm. Genome 4:303-313.
17. Mariani, P., P. A. Barrow, H. H. Cheng, M. M. Groenen, R. Negrini, and N. Bumstead. 2001. Localization to chicken chromosome 5 of a novel locus determining salmonellosis resistance. Immunogenetics 53:786-791.
18. Matthews, D. S., and V. T. Farewell. 1996. Using and understanding medical statistics, 3rd ed. Karger, Basel, Switzerland.
19. Mead, P. S., L. Slutsker, V. Dietz, L. F. McCaig, J. S. Bresee, C. Shapiro, P. M. Griffin, and R. V. Tauxe. 1999. Food-related illness and death in the United States. Emerg. Infect. Dis. 5:607-625.
20. Medzhitov, R., and C. Janeway, Jr. 2000. The Toll receptor family and microbial recognition. Trends Microbiol. 8:452-456.
21. Nanda, I., Z. Shan, M. Schartl, D. W. Burt, M. Koehler, H. Nothwang, F. Grutzner, I. R. Paton, D. Windsor, I. Dunn, W. Engel, P. Staeheli, S. Mizuno, T. Haaf, and M. Schmid. 1999. 300 million years of conserved synteny between chicken Z and human chromosome 9. Nat. Genet. 21:258-259.
22. Nicholas, K. B., H. B. J. Nicholas, and D. W. I. Deerfield. 1997. GeneDoc: analysis and visualization of genetic variation. EMBNEW Newsl. 4:14.
23. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088.
24. Qureshi, S. T., L. Lariviere, G. Leveque, S. Clermont, K. J. Moore, P. Gros, and D. Malo. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189:615-625.
25. Qureshi, S. T., L. Lariviere, G. Sebastiani, S. Clermont, E. Skamene, P. Gros, and D. Malo. 1996. A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics 31:283-294.
26. Rabsch, W., H. Tschape, and A. J. Baumler. 2001. Non-typhoidal salmonellosis: emerging problems. Microbes Infect. 3:237-247.
27. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. Sebastiani, G., L. Olien, S. Gauthier, E. Skamene, K. Morgan, P. Gros, and D. Malo. 1998. Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics 47:180-186.
29. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
30. Vidal, S. M., D. Malo, K. Vogan, E. Skamene, and P. Gros. 1993. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73:469-485.
31. Womack, J. E., and S. R. Kata. 1995. Bovine genome mapping: evolutionary inference and the power of comparative genomics. Curr. Opin. Genet. Dev. 5:725-733.
32. Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168:554-561.