Excess of rare amino acid polymorphisms in the toll-like receptor 4 in humans

Genetics

Volumn 158, Issue 4, 2001, Pages 1657-1664

  Smirnova, Irina ^a   Hamblin, Martha T ^b   McBride, Colleen ^a   Beutler, Bruce ^a,c   Rienzo, Anna Di ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ARTICLE; DISEASE PREDISPOSITION; GENE FREQUENCY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HOST SUSCEPTIBILITY; HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ALLELES; AMINO ACIDS; ANIMALS; DROSOPHILA PROTEINS; EVOLUTION; GORILLA GORILLA; HAPLOTYPES; HUMANS; MEMBRANE GLYCOPROTEINS; MUTATION; PAN PANISCUS; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PONGO PYGMAEUS; RECEPTORS, CELL SURFACE; SEQUENCE ANALYSIS, DNA; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; VARIATION (GENETICS);

EID: 0034858250     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
2. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
3. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
4. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide
5. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor
6. Statistical tests of neutrality of mutations
7. Toward a phylogenetic classification of primates based on DNA evidence complemented by fossil evidence
8. Consed: A graphical tool for sequence finishing
9. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures
10. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
11. A test of neutral molecular evolution based on nucleotide data
12. d mice
13. Adaptive protein evolution at the Adh locus in Drosophila
14. Contrasting evolutionary histories of two introns of the Duchenne muscular dystrophy gene, Dmd, in humans
15. PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
16. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
17. Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
18. Development of neutral and nearly neutral theories
19. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
20. Genetic and physical mapping of the Lps locusidentification of the toll-4 receptor as a candidate gene in the critical region
21. Adjusting the focus on human variation
22. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis
23. Genetic control of resistance to infection in mice
24. DnaSP version 2.0: A novel software package for extensive molecular population genetics analysis
25. Generation time and genomic evolution in primates
26. SNP frequencies in human genes: An excess of rare alleles and differing modes of selection
27. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
28. Population choice in mapping genes for complex diseases
29. Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila