The guanine nucleotide exchange factor RasGRF1 directly binds microtubules via DHPH2-mediated interaction

FEBS Journal

Volumn 273, Issue 10, 2006, Pages 2127-2138

  Forlani, Greta ^a   Baldassa, Simona ^a   Lavagni, Paola ^a   Sturani, Emmapaola ^a   Zippel, Renata ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

DHPH2 module; Microtubule; Ras; RasGRF; Sodium arsenate

Indexed keywords

BRAIN EXTRACT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PLECKSTRIN; PROTEIN DBL; PROTEIN RASGRF1; RAC PROTEIN; RAS PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; HUMANS; MICE; MICROTUBULES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS-GRF1; RECOMBINANT PROTEINS;

EID: 33646241782     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05226.x     Document Type: Article

References (53)

1. Diaz-Nido J 1997 The Cytoskeleton BIOS Scientific Publisher Oxford
2. Avila J Dominguez J Diaz-Nido J 1994 Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development Int J Dev Biol 38 13 25
3. Gundersen GG Cook TA 1999 Microtubules and signal transduction Curr Opin Cell Biol 11 81 94
4. Etienne-Manneville S Hall A 2002 Rho GTPases in cell biology Nature 420 629 635
5. Cook TA Nagasaki T Gundersen GG 1998 Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid J Cell Biol 141 175 185
6. Gundersen GG Kim I Chapin CJ 1994 Induction of stable microtubules in 3T3 fibroblasts by TGF-beta and serum J Cell Sci 107 645 659
7. Daub H Gevaert K Vandekerckhove J Sobel A Hall A 2001 Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16 J Biol Chem 276 1677 1680
8. Cen H Papageorge AG Zippel R Lowy DR Zhang K 1992 Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24 EMBO J 11 4007 4015
9. Martegani E Vanoni M Zippel R Coccetti P Brambilla R Ferrari C Sturani E Alberghina L 1992 Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator EMBO J 11 2151 2157
10. Wei W Das B Park W Broek D 1994 Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras Gene 151 279 284
11. Zippel R Orecchia S Sturani E Martegani E 1996 The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals Oncogene 12 2697 2703
12. Font de Mora J Esteban LM Burks DJ Nunez A Garces C Garcia-Barrado MJ Iglesias-Osma MC Moratinos J Ward JM Santos E 2003 Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis EMBO J 22 3039 3049
13. Fam NP Fan WT Wang Z Zhang LJ Chen H Moran MF 1997 Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras Mol Cell Biol 17 1396 1406
14. Kiyono M Satoh T Kaziro Y 1999 G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25 (Mm) Proc Natl Acad Sci USA 96 4826 4831
15. Kiyono M Kaziro Y Satoh T 2000 Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25 (Mm) following phosphorylation by the nonreceptor tyrosine kinase Src J Biol Chem 275 5441 5446
16. Innocenti M Zippel R Brambilla R Sturani E 1999 CDC25 (Mm) /Ras-GRF1 regulates both Ras and Rac signaling pathways FEBS Lett 460 357 362
17. Fan WT Koch CA de Hoog CL Fam NP Moran MF 1998 The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways Curr Biol 8 935 938
18. Farnsworth CL Freshney NW Rosen LB Ghosh A Greenberg ME Feig LA 1995 Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF Nature 376 524 527
19. Krapivinsky G Krapivinsky L Manasian Y Ivanov A Tyzio R Pellegrino C Ben-Ari Y Clapham DE Medina I 2003 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1 Neuron 40 775 784
20. Mattingly RR Macara IG 1996 Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits Nature 382 268 272
21. Zippel R Balestrini M Lomazzi M Sturani E 2000 Calcium and calmodulin are essential for Ras-GRF1-mediated activation of the Ras pathway by lysophosphatidic acid Exp Cell Res 258 403 408
22. Baouz S Jacquet E Accorsi K Hountondji C Balestrini M Zippel R Sturani E Parmeggiani A 2001 Sites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras J Biol Chem 276 1742 1749
23. Mattingly RR 1999 Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors J Biol Chem 274 37379 37384
24. Shou C Wurmser A Suen KL Barbacid M Feig LA Ling K 1995 Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals Oncogene 10 1887 1893
25. Zippel R Gnesutta N Matus-Leibovitch N Mancinelli E Saya D Vogel Z Sturani E 1997 Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system Brain Res Mol Brain Res 48 140 144
26. Sturani E Abbondio A Branduardi P Ferrari C Zippel R Martegani E Vanoni M Denis-Donini S 1997 The Ras Guanine nucleotide Exchange Factor CDC25Mm is present at the synaptic junction Exp Cell Res 235 117 123
27. Giese KP Friedman E Telliez JB Fedorov NB Wines M Feig LA Silva AJ 2001 Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1) Neuropharmacology 41 791 800
28. Brambilla R Gnesutta N Minichiello L White G Roylance AJ Herron CE Ramsey M Wolfer DP Cestari V Rossi-Arnaud C et al. 1997 A role for the Ras signalling pathway in synaptic transmission and long-term memory Nature 390 281 286
29. Tonini R Franceschetti S Parolaro D Sala M Mancinelli E Tininini S Brusetti R Sancini G Brambilla R Martegani E et al. 2001 Involvement of CDC25Mm/ Ras-GRF1-dependent signaling in the control of neuronal excitability Mol Cell Neurosci 18 691 701
30. Rubino T Forlani G Vigano D Zippel R Parolaro D 2004 Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment Mol Cell Neurosci 25 355 362
31. Rubino T Forlani G Vigano D Zippel R Parolaro D 2005 Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects J Neurochem 93 984 991
32. Spector DL Goldman RD Leinwand LA 1998 Cells: a Laboratory Manual Cold Spring Harbor Laboratory Press
33. Buchsbaum RJ Connolly BA Feig LA 2002 Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade Mol Cell Biol 22 4073 4085
34. Verhey KJ Meyer D Deehan R Blenis J Schnapp BJ Rapoport TA Margolis B 2001 Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules J Cell Biol 152 959 970
35. Vallee RB 1986 Purification of brain microtubules and microtubule-associated protein 1 using taxol Methods Enzymol 134 104 115
36. Buchsbaum R Telliez JB Goonesekera S Feig LA 1996 The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium Mol Cell Biol 16 4888 4896
37. Freshney NW Goonesekera SD Feig LA 1997 Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain FEBS Lett 407 111 115
38. Porter AC Fanger GR Vaillancourt RR 1999 Signal transduction pathways regulated by arsenate and arsenite Oncogene 18 7794 7802
39. Tanaka-Kagawa T Hanioka N Yoshida H Jinno H Ando M 2003 Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes Br J Dermatol 149 1116 1127
40. Ivanov PA Chudinova EM Nadezhdina ES 2003 Disruption of microtubules inhibits cytoplasmic ribonucleoprotein stress granule formation Exp Cell Res 290 227 233
41. Kranenburg O Moolenaar WH 2001 Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists Oncogene 20 1540 1546
42. 2+), and calmodulin Cell Signal 14 649 654
43. Seger R Krebs EG 1995 The MAPK signaling cascade FASEB J 9 726 735
44. Huang C Li J Ding M Wang L Shi X Castranova V Vallyathan V Ju G Costa M 2001 Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells Mol Cell Biochem 222 29 34
45. McEwen E Kedersha N Song B Scheuner D Gilks N Han A Chen JJ Anderson P Kaufman RJ 2005 Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure J Biol Chem 280 16925 16933
46. Tonini R Mancinelli E Balestrini M Mazzanti M Martegani E Ferroni A Sturani E Zippel R 1999 Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel Eur J Neurosci 11 959 966
47. van Horck FP Ahmadian MR Haeusler LC Moolenaar WH Kranenburg O 2001 Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules J Biol Chem 276 4948 4956
48. Ren Y Li R Zheng Y Busch H 1998 Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases J Biol Chem 273 34954 34960
49. Glaven JA Whitehead I Bagrodia S Kay R Cerione RA 1999 The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells J Biol Chem 274 2279 2285
50. Krendel M Zenke FT Bokoch GM 2002 Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton Nat Cell Biol 4 294 301
51. Huang C Bode AM Chen NY Ma WY Li J Nomura M Dong Z 2001 Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate Anticancer Res 21 261 267
52. Gao N Shen L Zhang Z Leonard SS He H Zhang XG Shi X Jiang BH 2004 Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells Mol Cell Biochem 255 33 45
53. Giasson BI Sampathu DM Wilson CA Vogelsberg-Ragaglia V Mushynski WE Lee VM 2002 The environmental toxin arsenite induces tau hyperphosphorylation Biochemistry 41 15376 15387