Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2

Molecular and Cellular Biology

Volumn 21, Issue 6, 2001, Pages 2107-2117

  De Hoog, Carmen L ^a,b   Koehler, Jackie A ^a,b   Goldstein, Marni D ^a   Taylor, Paul ^c   Figeys, Daniel ^c   Moran, Michael F ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MDS Proteomics Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN KINASE; RAS PROTEIN; SOS PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME BINDING; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; IONOMYCIN; IONOPHORES; LEUPEPTINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RAS-GRF1; SON OF SEVENLESS PROTEINS; UBIQUITINS;

EID: 0035014355     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.6.2107-2117.2001     Document Type: Article

References (48)

1. Abdellatif, M., W. R. MacLellan, and M. D. Schneider. 1994. p21 Ras as a governor of global gene expression. J. Biol. Chem. 269:15423-15426.
2. 1 cyclins in the next cycle. Cell 77:1037-1050.
3. Berridge, M. J. 1995. Calcium signalling and cell proliferation. Bioessays 17:491-500.
4. Boguski, M. S., and F. McCormick. 1993. Proteins regulating Ras and its relatives. Nature 366:643-654.
5. Boriack-Sjodin, P. A., S. M. Margarit, D. Bar-Sagi, and J. Kuriyan. 1998. The structural basis of the activation of Ras by Sos. Nature 394:337-343.
6. Camus, C., S. Hermann-Le Denmat, and M. Jacquet. 1995. Identification of guanine exchange factor key residues involved in exchange activity and Ras interaction. Oncogene 11:951-959.
7. Chen, L., L. J. Zhang, P. Greer, P. S. Tung, and M. F. Moran. 1993. A murine CDC25/ras-GRF-related protein implicated in Ras regulation. Dev. Genet. 14:339-346.
8. Ciechanover, A., A. Orian, and A. L. Schwartz. 2000. Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 22:442-451.
9. Craig, K. L., and M. Tyers. 1999. The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog. Biophys. Mol. Biol. 72:299-328.
10. Dahlmann, B., L. Kuehn, A. Grziwa, P. Zwickl, and W. Baumeister. 1992. Biochemical properties of the proteasome from Thermoplasma acidophilum. Eur. J. Biochem. 208:789-797.
11. de Hoog, C. L., W. T. Fan, M. D. Goldstein, M. F. Moran, and C. A. Koch. 2000. Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2. Mol. Cell. Biol. 20:2727-2733.
12. e in BALB/c 3T3 cells. Mol. Cell. Biol. 14:5441-5449.
13. 1 transit induced by the mitogenic-oncogenic viral Ki-ras gene product. Mol. Cell. Biol. 6:1386-1392.
14. Fam, N. P., W. T. Fan, Z. Wang, L. J. Zhang, H. Chen, and M. F. Moran. 1997. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol. Cell. Biol. 17:1396-1406.
15. Fan, W. T., C. A. Koch, C. L. de Hoog, N. P. Fam, and M. F. Moran. 1998. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Curr. Biol. 8:935-938.
16. 2+-binding site of RasH prevent its activation by GTP. Mol. Cell. Biol. 11:4822-4829.
17. Fenteany, G., R. F. Standaert, W. S. Lane, S. Choi, E. J. Corey, and S. L. Schreiber. 1995. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726-731.
18. Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138.
19. Hart, M., and S. Powers. 1995. Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro. Methods Enzymol. 255:129-135.
20. Holloway, S. L., M. Glotzer, R. W. King, and A. W. Murray. 1993. Anaphase is initiated by proteolysis rather than by the inactivation of maturationpromoting factor. Cell 73:1393-1402.
21. Kaplon, T., and M. Jacquet. 1995. The cellular content of Cdc25p, the Ras exchange factor in Saccharomyces cerevisiae, is regulated by destabilization through a cyclin destruction box. J. Biol. Chem. 270:20742-20747.
22. Kingston, R. E., P. Chomczynski, and N. Sacchi. 1996. Guanidine methods for total RNA preparation, p. 4.2.1-4.2.9. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 1. John Wiley & Sons, Inc., New York, N.Y.
23. Koegl, M., T. Hoppe, S. Schlenker, H. D. Ulrich, T. U. Mayer, and S. Jentsch. 1999. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96:635-644.
24. Kornitzer, D., and A. Ciechanover. 2000. Modes of regulation of ubiquitinmediated protein degradation. J. Cell. Physiol. 182:1-11.
25. Lee, D. H., and A. L. Goldberg. 1996. Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J. Biol. Chem. 271:27280-27284.
26. Li, S., V. Li, R. W. Carthew, and Z. C. Lai. 1997. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 90:469-478.
27. Lowy, D. R., and B. M. Willumsen. 1993. Function and regulation of ras. Annu. Rev. Biochem. 62:851-891.
28. Lu, Z., D. Liu, A. Hornia, W. Devonish, M. Pagano, and D. A. Foster. 1998. Activation of protein kinase C triggers its ubiquitination and degradation. Mol. Cell. Biol. 18:839-845.
29. Mattingly, R. R. 1999. Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors. J. Biol. Chem. 274:37379-37384.
30. Mattingly, R. R., and I. G. Macara. 1996. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature 382:268-272.
31. Mattingly, R. R., V. Saini, and I. G. Macara. 1999. Activation of the RasGRF/CDC25Mm exchange factor by lysophosphatidic acid. Cell. Signal. 11:603-610.
32. Mosteller, R. D., J. Han, and D. Broek. 1994. Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors. Mol. Cell. Biol. 14:1104-1112.
33. Mulcahy, L. S., M. R. Smith, and D. W. Stacey. 1985. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 313:241-243.
34. Nielsen, K. H., A. G. Papageorge, W. C. Vass, B. M. Willumsen, and D. R. Lowy. 1997. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol. Cell. Biol. 17:7132-7138.
35. Park, W., R. D. Mosteller, and D. Broek. 1994. Amino acid residues in the CDC25 guanine nudeotide exchange factor critical for interaction with Ras. Mol. Cell. Biol. 14:8117-8122.
36. Pfleger, C. M., and M. W. Kirschner. 2000. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14:655-665.
37. Pham, N., I. Cheglakov, C. A. Koch, C. L. de Hoog, M. F. Moran, and D. Rotin. 2000. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr. Biol. 10:555-558.
38. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
39. Shevchenko, A., I. Chernushevich, W. Ens, K. G. Standing, B. Thomson, M. Wilm, and M. Mann. 1997. Rapid 'de novo' peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 11:1015-1024.
40. Shevchenko, A., M. Wilm, O. Vorm, and M. Mann. 1996. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal. Chem. 68:850-858.
41. Stone, J. C., M. F. Moran, and T. Pawson. 1991. Construction and expression of linker insertion and site-directed mutants of the v-fps protein-tyrosine kinase. Methods Enzymol. 200:673-692.
42. Tang, A. H., T. P. Neufeld, E. Kwan, and G. M. Rubin. 1997. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SlNA-dependent mechanism. Cell 90:459-467.
43. Taylor, S. J., and D. Shalloway. 1996. Cell cycle-dependent activation of Ras. Curr. Biol. 6:1621-1627.
44. Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787-798.
45. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278:460-463.
46. Wilm, M., and M. Mann. 1996. Analytical properties of the nanoelectrospray ion source. Anal. Chem. 68:1-8.
47. cdc28-mediated control of Cln3 cyclin degradation. Mol. Cell. Biol. 15:731-741.
48. Yamano, H., J. Gannon, and T. Hunt. 1996. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. EMBO J. 15:5268-5279.