Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76- deficient T cell

Science

Volumn 281, Issue 5375, 1998, Pages 413-416

  Yablonski, Deborah ^a   Kuhne, Michelle R ^a   Kadlecek, Theresa ^a   Weiss, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; ENZYME ACTIVATION; GENE EXPRESSION; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CARRIER PROTEINS; CELL LINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INOSITOL PHOSPHATES; INTERLEUKIN-2; ISOENZYMES; JURKAT CELLS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0032541062     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5375.413     Document Type: Article

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46. We thank G. Koretzky for providing us with anti-serum to human SLP-76 and the SLP-76 cDNA and for communicating results before publication, L. Samelson for the antiserum to LAT, N. van Oers for the monoclonal antibodies to Vav, C. Liao for the antiserum to ltk, and the Weiss lab for their discussions and comments. Supported in part by a grant from the National Cancer Institute, CA72531.