Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback

Current Biology

Volumn 16, Issue 21, 2006, Pages 2173-2179

  Boykevisch, Sean ^a   Zhao, Chen ^a   Sondermann, Holger ^c   Philippidou, Polyxeni ^b   Halegoua, Simon ^b   Kuriyan, John ^d   Bar Sagi, Dafna ^e  

^a STONY BROOK UNIVERSITY   (United States)

^b Stony Brook University   (United States)

^c Department of Obstetrics Gynecology   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e New York School of Medicine   (United States)

Author keywords

CELLCYCLE

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN; SOS PROTEIN;

ANIMAL; ARTICLE; CELL STRAIN COS1; CERCOPITHECUS; FEEDBACK SYSTEM; HELA CELL; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, BIOCHEMICAL; HELA CELLS; HUMANS; RAS PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEINS;

EID: 33751102674     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.09.033     Document Type: Article

References (26)

1. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 (2000) 211-225
2. Freeman M. Feedback control of intercellular signalling in development. Nature 408 (2000) 313-319
3. Margarit S.M., Sondermann H., Hall B.E., Nagar B., Hoelz A., Pirruccello M., Bar-Sagi D., and Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112 (2003) 685-695
4. Sondermann H., Soisson S.M., Boykevisch S., Yang S.S., Bar-Sagi D., and Kuriyan J. Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell 119 (2004) 393-405
5. Hall B.E., Bar-Sagi D., and Nassar N. The structural basis for the transition from Ras-GTP to Ras-GDP. Proc. Natl. Acad. Sci. USA 99 (2002) 12138-12142
6. Hall B.E., Yang S.S., Boriack-Sjodin P.A., Kuriyan J., and Bar-Sagi D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J. Biol. Chem. 276 (2001) 27629-27637
7. Block C., Janknecht R., Herrmann C., Nassar N., and Wittinghofer A. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat. Struct. Biol. 3 (1996) 244-251
8. Herrmann C., Martin G.A., and Wittinghofer A. Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase. J. Biol. Chem. 270 (1995) 2901-2905
9. Corbalan-Garcia S., Margarit S.M., Galron D., Yang S.S., and Bar-Sagi D. Regulation of Sos activity by intramolecular interactions. Mol. Cell. Biol. 18 (1998) 880-886
10. Jorge R., Zarich N., Oliva J.L., Azanedo M., Martinez N., de la Cruz X., and Rojas J.M. HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain. J. Biol. Chem. 277 (2002) 44171-44179
11. Buday L., and Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Mol. Cell. Biol. 13 (1993) 1903-1910
12. Castro A.F., Rebhun J.F., and Quilliam L.A. Measuring Ras-family GTP levels in vivo-running hot and cold. Methods 37 (2005) 190-196
13. John J., Rensland H., Schlichting I., Vetter I., Borasio G.D., Goody R.S., and Wittinghofer A. Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. J. Biol. Chem. 268 (1993) 923-929
14. Spoerner M., Herrmann C., Vetter I.R., Kalbitzer H.R., and Wittinghofer A. Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc. Natl. Acad. Sci. USA 98 (2001) 4944-4949
15. Tan P.B., and Kim S.K. Signaling specificity: The RTK/RAS/MAP kinase pathway in metazoans. Trends Genet. 15 (1999) 145-149
16. Marshall C.J. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80 (1995) 179-185
17. Treisman R. Journey to the surface of the cell: Fos regulation and the SRE. EMBO J. 14 (1995) 4905-4913
18. Buday L., and Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73 (1993) 611-620
19. Obermeier A., Bradshaw R.A., Seedorf K., Choidas A., Schlessinger J., and Ullrich A. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J. 13 (1994) 1585-1590
20. Stephens R.M., Loeb D.M., Copeland T.D., Pawson T., Greene L.A., and Kaplan D.R. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12 (1994) 691-705
21. Traverse S., Seedorf K., Paterson H., Marshall C.J., Cohen P., and Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4 (1994) 694-701
22. Bhalla U.S., Ram P.T., and Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297 (2002) 1018-1023
23. Hanafusa H., Torii S., Yasunaga T., and Nishida E. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat. Cell Biol. 4 (2002) 850-858
24. Brandman O., Ferrell Jr. J.E., Li R., and Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310 (2005) 496-498
25. Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., and Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 394 (1998) 337-343
26. Ford B., Skowronek K., Boykevisch S., Bar-Sagi D., and Nassar N. Structure of the G60A mutant of Ras: Implications for the dominant negative effect. J. Biol. Chem. 280 (2005) 25697-25705