메뉴 건너뛰기




Volumn 57, Issue 5, 2000, Pages 840-846

The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN 1; CALPHOSTIN C; DIACYLGLYCEROL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; PHORBOL DIBUTYRATE; PHORBOL ESTER; PHOSPHOLIPID; PROTEIN KINASE C; RAS PROTEIN;

EID: 0034061660     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (115)

References (37)
  • 1
    • 0027258578 scopus 로고
    • Novel functional target for tumor-promoting phorbol ester and lysophosphatidic acid: The p21rac-GTPase activating protein n-chimaerin
    • Ahmed S, Lee J, Kozma R, Best A, Monfries C and Lim L (1993) Novel functional target for tumor-promoting phorbol ester and lysophosphatidic acid: The p21rac-GTPase activating protein n-chimaerin. J Biol Chem 268:10709-10712.
    • (1993) J Biol Chem , vol.268 , pp. 10709-10712
    • Ahmed, S.1    Lee, J.2    Kozma, R.3    Best, A.4    Monfries, C.5    Lim, L.6
  • 2
    • 0027518574 scopus 로고
    • Characterization of a guanine nucleotide dissociation stimulator for a Ras-related GTPase
    • Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA (1993) Characterization of a guanine nucleotide dissociation stimulator for a Ras-related GTPase. EMBO J 12:339-347.
    • (1993) EMBO J , vol.12 , pp. 339-347
    • Albright, C.F.1    Giddings, B.W.2    Liu, J.3    Vito, M.4    Weinberg, R.A.5
  • 3
    • 0028144758 scopus 로고
    • Close similarity of baculovirus expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors
    • Areces LB, Kazanietz MG and Blumberg PM (1994) Close similarity of baculovirus expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors. J Biol Chem 269:19553-19558.
    • (1994) J Biol Chem , vol.269 , pp. 19553-19558
    • Areces, L.B.1    Kazanietz, M.G.2    Blumberg, P.M.3
  • 4
    • 0000168479 scopus 로고
    • The bryostatins, a family of protein kinase C activators with therapeutic potential
    • Krogsgaard-Larsen P, Brogger Christensen S and Kofod H eds, Munksgaard International Publishers, Copenhagen
    • Blumberg PM and Pettit GR (1992) The bryostatins, a family of protein kinase C activators with therapeutic potential, in New Leads and Targets in Drug Research (Krogsgaard-Larsen P, Brogger Christensen S and Kofod H eds) pp 273-285, Munksgaard International Publishers, Copenhagen.
    • (1992) New Leads and Targets in Drug Research , pp. 273-285
    • Blumberg, P.M.1    Pettit, G.R.2
  • 6
    • 0028791349 scopus 로고
    • A phorbol ester/diacylglycerol-binding protein encoded by the Unc-13 gene of Caenorhabditis elegans
    • Brose N, Hofman K, Hata Y and Sudhof TC (1995) A phorbol ester/diacylglycerol-binding protein encoded by the Unc-13 gene of Caenorhabditis elegans. J Biol Chem 270:25273-25280.
    • (1995) J Biol Chem , vol.270 , pp. 25273-25280
    • Brose, N.1    Hofman, K.2    Hata, Y.3    Sudhof, T.C.4
  • 10
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanylnucleotide-releasing protein with calcium-and diacylglycerol-binding motifs
    • Ebinu JO, Bottorf DA, Chan EYM, Stang SL, Dunn RJ and Stone JC (1998) RasGRP, a Ras guanylnucleotide-releasing protein with calcium-and diacylglycerol-binding motifs. Science (Wash DC) 280:1082-1086.
    • (1998) Science (Wash DC) , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorf, D.A.2    Chan, E.Y.M.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 13
    • 0024320079 scopus 로고
    • Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C
    • Kaibuchi K, Fukumoto Y, Oku N, Takai Y, Arai K and Muramatsu M (1989) Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C. J Biol Chem 264:13489-13496.
    • (1989) J Biol Chem , vol.264 , pp. 13489-13496
    • Kaibuchi, K.1    Fukumoto, Y.2    Oku, N.3    Takai, Y.4    Arai, K.5    Muramatsu, M.6
  • 14
    • 0027297104 scopus 로고
    • Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
    • Kazanietz MG, Areces LB, Bahador A, Mischak H, Goodnight J, Mushinski JF and Blumberg PM (1993) Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol 44:298-307.
    • (1993) Mol Pharmacol , vol.44 , pp. 298-307
    • Kazanietz, M.G.1    Areces, L.B.2    Bahador, A.3    Mischak, H.4    Goodnight, J.5    Mushinski, J.F.6    Blumberg, P.M.7
  • 15
    • 0028914673 scopus 로고
    • Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor: Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity
    • Kazanietz MG, Lewin NE, Bruns JD and Blumberg PM (1995a) Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor: Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. J Biol Chem 270:10777-10783.
    • (1995) J Biol Chem , vol.270 , pp. 10777-10783
    • Kazanietz, M.G.1    Lewin, N.E.2    Bruns, J.D.3    Blumberg, P.M.4
  • 17
    • 0029102822 scopus 로고
    • Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis
    • Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL and Blumberg PM (1995b) Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem 270:21852-21859.
    • (1995) J Biol Chem , vol.270 , pp. 21852-21859
    • Kazanietz, M.G.1    Wang, S.2    Milne, G.W.3    Lewin, N.E.4    Liu, H.L.5    Blumberg, P.M.6
  • 18
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R, Solski P, Clark GJ, Kinch MS and Der CJ (1995) Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 15:6443-6453.
    • (1995) Mol Cell Biol , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 19
    • 0029779004 scopus 로고    scopus 로고
    • The GTPase activating protein n-chimaerin cooperates with Rac-1 and CdC42H to induce the formation of lamellipodia and filopodia
    • Kozma R, Ahmed S, Best A and Lim L (1996) The GTPase activating protein n-chimaerin cooperates with Rac-1 and CdC42H to induce the formation of lamellipodia and filopodia. Mol Cell Biol 16:5069-5080.
    • (1996) Mol Cell Biol , vol.16 , pp. 5069-5080
    • Kozma, R.1    Ahmed, S.2    Best, A.3    Lim, L.4
  • 20
    • 0024427970 scopus 로고
    • Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding, and binding to mixed micelles
    • Lee MH and Bell RM (1989) Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding, and binding to mixed micelles. J Biol Chem 264:14797-14805.
    • (1989) J Biol Chem , vol.264 , pp. 14797-14805
    • Lee, M.H.1    Bell, R.M.2
  • 24
    • 0033538433 scopus 로고    scopus 로고
    • Interplay of C1 and C2 domains of protein kinase C-α in its membrane binding and activation
    • Medkova M and Cho W (1999) Interplay of C1 and C2 domains of protein kinase C-α in its membrane binding and activation. J Biol Chem 274:19852-19861.
    • (1999) J Biol Chem , vol.274 , pp. 19852-19861
    • Medkova, M.1    Cho, W.2
  • 25
    • 0028811653 scopus 로고
    • Protein kinase C: Structure, function, and regulation
    • Newton AC (1995) Protein kinase C: Structure, function, and regulation. J Biol Chem 270:28495-28498.
    • (1995) J Biol Chem , vol.270 , pp. 28495-28498
    • Newton, A.C.1
  • 26
    • 0032555778 scopus 로고    scopus 로고
    • Protein kinase C: A paradigm for regulation of protein function by two membrane-targeting modules
    • Newton AC and Johnson JE (1998) Protein kinase C: A paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta 1376: 155-172.
    • (1998) Biochim Biophys Acta , vol.1376 , pp. 155-172
    • Newton, A.C.1    Johnson, J.E.2
  • 28
    • 0026635971 scopus 로고
    • Interaction of protein kinase C with phosphatidylserine: 2. Specificity and regulation
    • Orr JW and Newton AC (1992) Interaction of protein kinase C with phosphatidylserine: 2. Specificity and regulation. Biochemistry 31:4667-4673.
    • (1992) Biochemistry , vol.31 , pp. 4667-4673
    • Orr, J.W.1    Newton, A.C.2
  • 29
    • 0030134530 scopus 로고    scopus 로고
    • Clinical trials referral resource: Clinical trials using bryostatin-1
    • Pluda JM, Cheson BD and Phillips PH (1996) Clinical trials referral resource: Clinical trials using bryostatin-1. Oncology 10:740-742.
    • (1996) Oncology , vol.10 , pp. 740-742
    • Pluda, J.M.1    Cheson, B.D.2    Phillips, P.H.3
  • 32
    • 0026659515 scopus 로고
    • Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Rasp21
    • Shou C, Farnsworth CL, Neel BG and Feig LA (1992) Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Rasp21. Nature (Lond) 258: 351-358.
    • (1992) Nature (Lond) , vol.258 , pp. 351-358
    • Shou, C.1    Farnsworth, C.L.2    Neel, B.G.3    Feig, L.A.4
  • 33
    • 0030053828 scopus 로고    scopus 로고
    • Expression and characterization of Aplysia protein kinase C: A negative regulatory role for the E region
    • Sossin WS, Fan X and Saberi F (1996) Expression and characterization of Aplysia protein kinase C: A negative regulatory role for the E region. J Neurosci 16:10-18.
    • (1996) J Neurosci , vol.16 , pp. 10-18
    • Sossin, W.S.1    Fan, X.2    Saberi, F.3
  • 34
    • 0027276016 scopus 로고
    • (2+)'-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence
    • (2+)'-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence. Trends Biochem Sci 18:207-208.
    • (1993) Trends Biochem Sci , vol.18 , pp. 207-208
    • Sossin, W.S.1    Schwartz, J.H.2
  • 37
    • 0027964870 scopus 로고
    • Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain
    • Valverde AM, Sunnett-Smith J, Van Lint J and Rozengurt E (1994) Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc Natl Acad Sci USA 91: 8572-8576.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8572-8576
    • Valverde, A.M.1    Sunnett-Smith, J.2    Van Lint, J.3    Rozengurt, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.