-
2
-
-
0027931640
-
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
-
Aronheim A., Engelberg D., Li N., al-Alawi N., Schlessinger J., Karin M. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell. 78:1994;949-961
-
(1994)
Cell
, vol.78
, pp. 949-961
-
-
Aronheim, A.1
Engelberg, D.2
Li, N.3
Al-Alawi, N.4
Schlessinger, J.5
Karin, M.6
-
4
-
-
3543012707
-
Crystallography & NMR system: A new software suite for macromolecular structure determination
-
Brünger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., et al. Crystallography & NMR system. a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54:1998;905-921
-
(1998)
Acta Crystallogr. D Biol. Crystallogr.
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
-
5
-
-
0027153103
-
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
-
Buday L., Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell. 73:1993;611-620
-
(1993)
Cell
, vol.73
, pp. 611-620
-
-
Buday, L.1
Downward, J.2
-
6
-
-
0029849810
-
P21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus
-
Byrne J.L., Paterson H.F., Marshall C.J. p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene. 13:1996;2055-2065
-
(1996)
Oncogene
, vol.13
, pp. 2055-2065
-
-
Byrne, J.L.1
Paterson, H.F.2
Marshall, C.J.3
-
7
-
-
0031002348
-
The role of the PH domain in the signal-dependent membrane targeting of Sos
-
Chen R.H., Corbalan-Garcia S., Bar-Sagi D. The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J. 16:1997;1351-1359
-
(1997)
EMBO J.
, vol.16
, pp. 1351-1359
-
-
Chen, R.H.1
Corbalan-Garcia, S.2
Bar-Sagi, D.3
-
9
-
-
0031882763
-
Regulation of Sos activity by intramolecular interactions
-
Corbalan-Garcia S., Margarit S.M., Galron D., Yang S.S., Bar-Sagi D. Regulation of Sos activity by intramolecular interactions. Mol. Cell. Biol. 18:1998;880-886
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 880-886
-
-
Corbalan-Garcia, S.1
Margarit, S.M.2
Galron, D.3
Yang, S.S.4
Bar-Sagi, D.5
-
10
-
-
0034685772
-
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding
-
Das B., Shu X., Day G.J., Han J., Krishna U.M., Falck J.R., Broek D. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J. Biol. Chem. 275:2000;15074-15081
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15074-15081
-
-
Das, B.1
Shu, X.2
Day, G.J.3
Han, J.4
Krishna, U.M.5
Falck, J.R.6
Broek, D.7
-
11
-
-
0027910431
-
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
-
Egan S.E., Giddings B.W., Brooks M.W., Buday L., Sizeland A.M., Weinberg R.A. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 363:1993;45-51
-
(1993)
Nature
, vol.363
, pp. 45-51
-
-
Egan, S.E.1
Giddings, B.W.2
Brooks, M.W.3
Buday, L.4
Sizeland, A.M.5
Weinberg, R.A.6
-
12
-
-
0033635275
-
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
-
Ferguson K.M., Kavran J.M., Sankaran V.G., Fournier E., Isakoff S.J., Skolnik E.Y., Lemmon M.A. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol. Cell. 6:2000;373-384
-
(2000)
Mol. Cell
, vol.6
, pp. 373-384
-
-
Ferguson, K.M.1
Kavran, J.M.2
Sankaran, V.G.3
Fournier, E.4
Isakoff, S.J.5
Skolnik, E.Y.6
Lemmon, M.A.7
-
13
-
-
0027229556
-
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
-
Gale N.W., Kaplan S., Lowenstein E.J., Schlessinger J., Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature. 363:1993;88-92
-
(1993)
Nature
, vol.363
, pp. 88-92
-
-
Gale, N.W.1
Kaplan, S.2
Lowenstein, E.J.3
Schlessinger, J.4
Bar-Sagi, D.5
-
14
-
-
0035920116
-
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
-
Hall B.E., Yang S.S., Boriack-Sjodin P.A., Kuriyan J., Bar-Sagi D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J. Biol. Chem. 276:2001;27629-27637
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27629-27637
-
-
Hall, B.E.1
Yang, S.S.2
Boriack-Sjodin, P.A.3
Kuriyan, J.4
Bar-Sagi, D.5
-
15
-
-
0036371326
-
Autoinhibition of Sos by intramolecular interactions
-
Hall B.E., Yang S.S., Bar-Sagi D. Autoinhibition of Sos by intramolecular interactions. Front. Biosci. 7:2002;d288-d294
-
(2002)
Front. Biosci.
, vol.7
-
-
Hall, B.E.1
Yang, S.S.2
Bar-Sagi, D.3
-
16
-
-
0036565668
-
The complex of Arl2-GTP and PDE delta: From structure to function
-
Hanzal-Bayer M., Renault L., Roversi P., Wittinghofer A., Hillig R.C. The complex of Arl2-GTP and PDE delta. from structure to function EMBO J. 21:2002;2095-2106
-
(2002)
EMBO J.
, vol.21
, pp. 2095-2106
-
-
Hanzal-Bayer, M.1
Renault, L.2
Roversi, P.3
Wittinghofer, A.4
Hillig, R.C.5
-
17
-
-
0032554774
-
Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1)
-
Kim J.H., Shirouzu M., Kataoka T., Bowtell D., Yokoyama S. Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1). Oncogene. 16:1998;2597-2607
-
(1998)
Oncogene
, vol.16
, pp. 2597-2607
-
-
Kim, J.H.1
Shirouzu, M.2
Kataoka, T.3
Bowtell, D.4
Yokoyama, S.5
-
19
-
-
0036928818
-
Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions
-
Kraemer A., Brinkmann T., Plettner I., Goody R., Wittinghofer A. Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions. J. Mol. Biol. 324:2002;763-774
-
(2002)
J. Mol. Biol.
, vol.324
, pp. 763-774
-
-
Kraemer, A.1
Brinkmann, T.2
Plettner, I.3
Goody, R.4
Wittinghofer, A.5
-
20
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
-
Li N., Batzer A., Daly R., Yajnik V., Skolnik E., Chardin P., Bar-Sagi D., Margolis B., Schlessinger J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363:1993;85-88
-
(1993)
Nature
, vol.363
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
Yajnik, V.4
Skolnik, E.5
Chardin, P.6
Bar-Sagi, D.7
Margolis, B.8
Schlessinger, J.9
-
21
-
-
0344885558
-
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit S.M., Sondermann H., Hall B.E., Nagar B., Hoelz A., Pirruccello M., Bar-Sagi D., Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 112:2003;685-695
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
Bar-Sagi, D.7
Kuriyan, J.8
-
22
-
-
0025117674
-
Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic ras proteins
-
Milburn M.V., Tong L., deVos A.M., Brünger A., Yamaizumi Z., Nishimura S., Kim S.H. Molecular switch for signal transduction. structural differences between active and inactive forms of protooncogenic ras proteins Science. 247:1990;939-945
-
(1990)
Science
, vol.247
, pp. 939-945
-
-
Milburn, M.V.1
Tong, L.2
Devos, A.M.3
Brünger, A.4
Yamaizumi, Z.5
Nishimura, S.6
Kim, S.H.7
-
23
-
-
0037072242
-
The two hats of SOS
-
10.1126/stke.2002.145.pe36
-
Nimnual, A., and Bar-Sagi, D. (2002). The two hats of SOS. Sci STKE 2002, PE36. 10.1126/stke.2002.145.pe36
-
(2002)
Sci STKE 2002
-
-
Nimnual, A.1
Bar-Sagi, D.2
-
24
-
-
0032559211
-
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
-
Nimnual A.S., Yatsula B.A., Bar-Sagi D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science. 279:1998;560-563
-
(1998)
Science
, vol.279
, pp. 560-563
-
-
Nimnual, A.S.1
Yatsula, B.A.2
Bar-Sagi, D.3
-
25
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:1997;307-326
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
26
-
-
0025310575
-
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: Implications for the mechanism of GTP hydrolysis
-
Pai E.F., Krengel U., Petsko G.A., Goody R.S., Kabsch W., Wittinghofer A. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution. implications for the mechanism of GTP hydrolysis EMBO J. 9:1990;2351-2359
-
(1990)
EMBO J.
, vol.9
, pp. 2351-2359
-
-
Pai, E.F.1
Krengel, U.2
Petsko, G.A.3
Goody, R.S.4
Kabsch, W.5
Wittinghofer, A.6
-
27
-
-
0031929680
-
N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains
-
Qian X., Vass W.C., Papageorge A.G., Anborgh P.H., Lowy D.R. N terminus of Sos1 Ras exchange factor. critical roles for the Dbl and pleckstrin homology domains Mol. Cell. Biol. 18:1998;771-778
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 771-778
-
-
Qian, X.1
Vass, W.C.2
Papageorge, A.G.3
Anborgh, P.H.4
Lowy, D.R.5
-
28
-
-
4444297885
-
New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function
-
Silver S.J., Chen F., Doyon L., Zink A.W., Rebay I. New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function. Genesis. 39:2004;263-272
-
(2004)
Genesis
, vol.39
, pp. 263-272
-
-
Silver, S.J.1
Chen, F.2
Doyon, L.3
Zink, A.W.4
Rebay, I.5
-
29
-
-
1542609420
-
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation
-
Sini P., Cannas A., Koleske A.J., Di Fiore P.P., Scita G. Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat. Cell Biol. 6:2004;268-274
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 268-274
-
-
Sini, P.1
Cannas, A.2
Koleske, A.J.3
Di Fiore, P.P.4
Scita, G.5
-
30
-
-
0032538316
-
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein
-
Soisson S.M., Nimnual A.S., Uy M., Bar-Sagi D., Kuriyan J. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell. 95:1998;259-268
-
(1998)
Cell
, vol.95
, pp. 259-268
-
-
Soisson, S.M.1
Nimnual, A.S.2
Uy, M.3
Bar-Sagi, D.4
Kuriyan, J.5
-
31
-
-
0345528059
-
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless
-
Sondermann H., Soisson S.M., Bar-Sagi D., Kuriyan J. Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure. 11:2003;1583-1593
-
(2003)
Structure
, vol.11
, pp. 1583-1593
-
-
Sondermann, H.1
Soisson, S.M.2
Bar-Sagi, D.3
Kuriyan, J.4
-
32
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter I.R., Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science. 294:2001;1299-1304
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
33
-
-
0034619877
-
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
-
Worthylake D.K., Rossman K.L., Sondek J. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature. 408:2000;682-688
-
(2000)
Nature
, vol.408
, pp. 682-688
-
-
Worthylake, D.K.1
Rossman, K.L.2
Sondek, J.3
|