Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

Nature

Volumn 424, Issue 6949, 2003, Pages 694-698

  Bivona, Trever G ^a   Pérez de Castro, Ignacio ^a   Ahearn, Ian M ^a   Grana, Theresa M ^b   Chiu, Vi K ^a   Lockyer, Peter J ^c   Cullen, Peter J ^d   Pellicer, Angel ^a   Cox, Adrienne D ^b   Philips, Mark R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; NUCLEIC ACIDS; PHYSIOLOGY; TUMORS;

PLASMA MEMBRANES;

PROTEINS;

CALCIUM; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHOLIPASE C; PROTEIN KINASE P60; RAS PROTEIN; DNA BINDING PROTEIN; PHOSPHOLIPASE C GAMMA; RASA4 PROTEIN, HUMAN; RASGRP1 PROTEIN, HUMAN; RASGRP1 PROTEIN, RAT;

BIOLOGY; PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GOLGI COMPLEX; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RADIOSENSITIVITY; ANIMAL; CELL STRAIN; CELL STRAIN COS1; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CELL MEMBRANE; COS CELLS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FIBROBLASTS; GOLGI APPARATUS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTRACELLULAR MEMBRANES; JURKAT CELLS; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; RATS; SIGNAL TRANSDUCTION;

EID: 0041488671     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01806     Document Type: Article

References (19)

1. Choy, E. et al. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98, 69-80 (1999).
2. Chiu, V. K. et al. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biol. 4, 343-350 (2002).
3. Lockyer, P. J., Kupzig, S. & Cullen, P. J. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Curr. Biol. 11, 981-986 (2001).
4. Cullen, P. J. & Lockyer, P. J. Integration of calcium and Ras signalling. Nature Rev. Mol. Cell Biol. 3, 339-348 (2002).
5. Yue, L., Peng, J. B., Hediger, M. A. Clapham, D. E. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410, 705-709 (2001).
6. Ji, Q. S., Ermini, S., Baulida, J., Sun, F. L & Carpenter, G. Epidermal growth factor signaling and mitogenesis in Plcγ1 null mouse embryonic fibroblasts. Mol. Biol. Cell 9, 749-757 (1998).
7. Ehrhardt, A., Ehrhardt, G. R., Guo, X. & Schrader, J. W. Ras and relatives - job sharing and networking keep an old family together. Exp. Hematol. 30, 1089-1106 (2002).
8. Baron, C. L. & Malhotra, V. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science 295, 325-328 (2002).
9. Bankaitis, V. A. Slick recruitment to the Golgi. Science 295, 290-291 (2002).
10. Ebinu, J. O. et al. RasGRP links T-cell receptor signaling to Ras. Blood 95, 3199-3203 (2000).
11. Dower, N. A. et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nature Immunol. 1, 317-321 (2000).
12. Park, W., Mosteller, R. D. & Broek, D. Identification of a dominant-negative mutation in the yeast CDC25 guanine nucleotide exchange factor for Ras. Oncogene 14, 831-836 (1997).
13. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
14. Ebinu, J. O. et al. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280, 1082-1086 (1998).
15. Tognon, C. E. et al. Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol. Cell Biol. 18, 6995-7008 (1998).
16. 2+ influx. J. Biol. Chem. 271, 7883-7886 (1996).
17. Lewis, R. S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19, 497-521 (2001).
18. Marshall, C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185 (1995).
19. Yamashita, S. et al. CalDAG-GEFIII activation of Ras, R-ras, and Rap1. J. Biol. Chem. 275, 25488-25493 (2000).