G protein mechanisms: Insights from structural analysis

Annual Review of Biochemistry

Volumn 66, Issue , 1997, Pages 639-678

  Sprang, Stephen R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Elongation factors; G proteins; Protein tertiary structure; Ras like proteins; Receptors

Indexed keywords

ELONGATION FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MAGNESIUM; NUCLEOTIDE; PHOSPHATE; PROTEIN P21; PROTEIN SUBUNIT; RAS PROTEIN;

AMINO TERMINAL SEQUENCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENERGY; HYDROLYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; REVIEW; X RAY CRYSTALLOGRAPHY;

ANIMALS; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDES; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 0030920782     PISSN: 00664154     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.66.1.639     Document Type: Review

References (249)

1. Bourne HR, Sanders DA, McCormick F. 1990. Nature 348:125-32
2. Kjeldgaard M, Nyborg J, Clark BFC. 1996. FASEB J. 10:1347-68
3. Bourne HR, Sanders DA, McCormick F. 1991. Nature 349:117-27
4. Morikawa K, La Cour TFM, Nyborg J, Rasmussen KM, Miller DL, Clark BFC. 1978. J. Mol. Biol. 125:325-38
5. Jurnak F, McPherson A, Wang AHJ, Rich A. 1980. J. Biol. Chem. 255:6751-57
6. Jurnak F. 1985. Science 230:32-36
7. LaCour TFM, Nyborg J, Thirup S, Clark BFC. 1985. EMBO J. 4:2385-88
8. Bränden C-I. 1980. Q. Rev. Biophys. 13:317-38
9. Dever TE, Glynias MJ, Merrick WC. 1987. Proc. Natl. Acad. Sci. USA 84: 1814-18
10. Halliday KR. 1984. J. Cycl. Nucleoride Protein Phosphoryl. Res. 9:435-48
11. McCormick F, Clark BFC, La Cour TFM, Kjeldgaard M, Norskov-Lauritsen L, Nyborg J. 1985. Science 230:78-82
12. Gilman AG. 1987. Annu. Rev. Biochem. 56:615-49
13. Möller W, Amons R. 1985. FEBS Lett. 186:1-7
14. Walker JE, Saraste M, Runswick MJ, Gay NJ. 1982. EMBO J. 1:945-51
15. Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A. 1990. EMBO J. 9:2351-59
16. Tong L, de Vos AM, Milburn MV, Kim S-H. 1991. J. Mol. Biol. 217:503-16
17. Kjeldgaard M, Nissen P, Thirup S, Nyborg J. 1993. Structure 1:35-50
18. Berchtold H, Reshetnikova L, Reiser COA, Schirmer NK, Sprinzl M, Hilgenfeld R. 1993. Nature 365:126-32
19. Kjeldgaard M, Nyborg J. 1992. J. Mol. Biol. 223:721-42
20. Polekhina G, Thirup S, Kjeldgaard M, Nissen P, Lippmann C, Nyborg J. 1996, Structure 4:1141-51
21. Noel JP, Hamm HE, Sigler PB. 1993. Nature 366:654-63
22. Lambright DG, Noel JP, Hamm HE, Sigler PB. 1994. Nature 369:621-28
23. Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. 1994. Science 265:1405-12
24. Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR. 1995. Science 270:954-60
25. Barbacid M. 1987. Annu. Rev. Biochem. 56:779-827
26. Nuoffer C, Balch WE. 1994. Annu. Rev. Biochem. 63:949-90
27. Macara IG, Lounsbury KM, Richards SA, McKiernan C, Bar-Sagi D. 1996. FASEB J. 10:625-30
28. Grand RJA, Owen D. 1991. Biochem. J. 279:609-31
29. Tong L, Milburn MV, de Vos AM, Kim S-H. 1989. Science 245:244
30. Pai EF, Kabsch W, Krengel U, Holmes KC, John J, Wittinghofer A. 1989. Nature 341:209-14
31. de Vos AM, Tong L, Milburn MV, Matias PM, Jancarik J, et al. 1988. Science 239:888-93
32. Milburn MV, Tong L, deVos AM, Brünger A, Yamaizumi Z, et al. 1990. Science 247:939-45
33. Privé GG, Milburn MV, Tong L, deVos AM, Yamaizumi Z, et al. 1992. Proc. Natl. Acad. Sci. USA 89:3649-53
34. Schlichting I, Almo SC, Rapp G, Wilson K, John J, et al. 1990. Nature 345:309-15
35. Krengel U, Schlichting I, Scherer A, Schumann R, Frech M, et al. 1990. Cell 62:539-48
36. Scheidig AJ, Franken SM, Come JET, Reid GP, Wittinghofer A, et al. 1995. J. Mol. Biol. 253:132-50
37. John J, Schlichting I, Schiltz E, Rösch P, Wittinghofer A. 1989. J. Biol. Chem. 264:13086-92
38. Casey PJ. 1995. Science 268:221-25
39. Marshall MS. 1993. Trends Biochem. Sci. 18:250-54
40. Kraulis PJ, Domaille PJ, Campbell-Burk SL, Van Aken T, Laue ED. 1994. Biochemistry 33:3515-31
41. Nassar M, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A. 1995. Nature 375:554-60
42. Schlenstedt G. 1966. FEBS Lett. 389:75-79
43. Scheffzek K, Klebe C, Fritz-Wolf K, Kabsch W, Wittinghofer A. 1995. Nature 374:378-81
44. Amor JC, Harrison DH, Kahn DH, Ringe D. 1994. Nature 372:704-8
45. Greasley SE, Jhoti H, Teahan C, Solari R, Fensome A, et al. 1995. Nat. Struct. Biol. 2:797-806
46. Kahn RA, Gilman AG. 1986. J. Biol. Chem. 261:7906-11
47. Rothman JE. 1994. Nature 372:55-63
48. Brown HA, Gutowski S, Moomaw CR, Slaughter C, Sternweis PC. 1993. Cell 75:1137-44
49. Abel K, Jurnak F. 1996. Structure 4:229-38
50. Peter ME, Schirmer NK, Reiser COA, Sprinzl M. 1990. Biochemistry 29:2876-84
51. Abel K, Yoder MD, Hilgenfeld R, Jurnak F. 1996. Structure 4:1153-59
52. Aevarsson A, Brazhnikov E, Garber M, Zheltonosova J, Chirgadze Y, et al. 1994. EMBO J. 13:3669-77
53. Czworkowski J, Wang J, Steitz TA, Moore PB. 1994. EMBO J. 13:3661-68
54. Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, et al. 1995. Science 270:1464-72
55. Moore PB. 1995. Science 270:1453-54
56. Kaziro Y, Itoh H, Kozasa T, Nakafuku M, Satoh T. 1991. Annu. Rev. Biochem. 60:349-400
57. Hamm HE, Gilchrist A. 1996. Curr. Opin. Cell Biol. 8:189-96
58. Rens-Domiano S, Hamm HE. 1995. FASEB J. 9:1059-66
59. Helmreich E, Hofmann K-P. 1996. Biochem. Biophys. Acta 1286:285-322
60. Sunahara RK, Dessauer CW, Gilman AG. 1996. Annu. Rev. Pharmacol. Toxicol. 36:461-80
61. Markby DW, Onrust R, Bourne HR. 1993. Science 262:1895-901
62. Benjamin DR, Markby DW, Bourne HR, Kuntz ID. 1995. J. Mol. Biol. 254:681-91
63. Freissmuth M, Gilman AG. 1989. J. Biol. Chem. 264:21907-14
64. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. 1989. Nature 340:692-96
65. Antonelli M, Birnbaumer L, Allende JE, Olate J. 1994. FEBS Lett. 340:249-54
66. Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM. 1993. Proc. Natl. Acad. Sci. USA 90: 3675-79
67. Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. 1993. J. Biol. Chem. 268:25001-8
68. Veit M, Nürnberg B, Spicher K, Harteneck C, Ponimaskin E, et al. 1994. FEBS Lett. 339:160-64
69. Gallego C, Gupta SK, Winitz S, Eisfelder BJ, Johnson GL. 1992. Proc. Natl. Acad. Sci. USA 89:9695-99
70. Wilson PT, Bourne HR. 1995. J. Biol. Chem. 270:9667-75
71. Wedegaertner PB, Bourne HR. 1994. Cell 77:1063-70
72. Mumby SM, Kleuss C, Oilman AG. 1994. Proc. Natl. Acad. Sci. USA 91:2800-4
73. Wedegaertner PB, Wilson PT, Bourne HR. 1995. J. Biol. Chem. 270:503-6
74. Milligan G, Parenti M, Magee AI. 1995. Trends Biochem. Sci. 20:181-86
75. Van Dop C, Tsubokawa M, Bourne HR, Ramachandran J. 1984. J. Biol. Chem. 259:696-98
76. John J, Sohmen R, Feuerstein J, Linke R, Wittinghofer A, Goody RS. 1990. Biochemistry 29:6058-65
77. Feuerstein J, Kalbitzer HR, John J, Goody RS, Wittinghofer A. 1987. Eur. J. Biochem. 162:49-55
78. Feuerstein J, Goody RS, Wittinghofer A. 1987 J. Biol. Chem. 262:8455-58
79. Ferguson KM, Higashijima T, Smigel MD, Gilman AG. 1986. J. Biol. Chem. 261:7393-99
80. Goody RS, Frech M, Wittinghofer A. 1991. Trends Biochem. Sci. 16:327-28
81. Arai K-I, Arai N, Nakamura S, Oshima T, Kaziro Y. 1978. Eur. J. Biochem. 92:521-31
82. Wagner A, Simon I, Sprinzl M, Goody RS. 1995. Biochemistry 34:12535-42
83. Higashijima T, Ferguson KM, Sternweis PC, Smigel MD, Gilman AG. 1987. J. Biol. Chem. 262:762-66
84. Lee E, Taussig R, Gilman AG. 1992. J. Biol. Chem. 267:1212-18
85. Northup JK, Smigel MD, Gilman AG. 1982. J. Biol. Chem. 257:11416-23
86. Higashijima T, Ferguson KM, Sternweis PC, Ross EM, Smigel MD, Gilman AG. 1987. J. Biol. Chem. 262:752-56
87. John J, Frech M, Wittinghofer A. 1988. J. Biol. Chem. 263:11792-99
88. Arai K-I, Kawakita M, Kaziro Y. 1972. J. Biol. Chem. 247:7029-37
89. John J, Rensland H, Schlichting I, Vetter I, Borasio GD, et al. 1993. J. Biol. Chem. 268:923-29
90. Fawzi AB, Northup JK. 1990. Biochemistry 29:3804-12
91. Casey PJ, Fong HK, Simon MI, Gilman AG. 1990. J. Biol. Chem. 265:2383-90
92. Hepler JR, Kozasa T, Smrcka AV, Simon MI, Rhee SG, et al. 1993. J. Biol. Chem. 268:14367-75
93. Franken SM, Scheidig AJ, Krengel U, Rensland H, Lautwein A, et al. 1993. Biochemistry 32:8411-20
94. Slepak VZ, Quick MW, Aragay AM, Davidson N, Lester HA, Simon MI. 1993. J. Biol. Chem. 268:21889-94
95. Slepak VZ, Katz A, Simon MI. 1995. J. Biol. Chem. 270:4037-41
96. Denker BM, Neer EJ, Schmidt CJ. 1992. J. Biol. Chem. 267:6272-77
97. Denker BM, Boutin PM, Neer EJ. 1995. Biochemistry 34:5544-53
98. Rensland H, Linke JR, Simon I, Schlichting I, Wittinghofer A, Goody RS. 1995. Biochemistry 34:593-99
99. Zhong JM, Chen-Hwang MC, Hwang YW. 1995. J. Biol. Chem. 270:10002-7
100. Hwang Y-W, Miller DL. 1987. J. Biol. Chem. 262:13081-85
101. Schmidt G, Lenzen C, Simon I, Deuter R, Cool RH, et al. 1996. Oncogene 12:87-96
102. Weijland A, Parlato G, Parmeggiani A. 1994. Biochemistry 33:10711-17
103. Neal SE, Eccleston JF, Webb MR. 1990. Proc. Natl. Acad. Sci. USA 87:3562-65
104. Stouten PFW, Sander C, Wittinghofer A, Valencia A. 1993. FEBS Lett. 320:1-6
105. Sung Y-J, Carter M, Zhong J-M, Hwang Y-W. 1995. Biochemistry 34:3470-77
106. Miller RT, Masters SB, Sullivan KA, Beiderman B, Bourne HR. 1988. Nature 334:712-15
107. Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR. 1996. Structure. In press
108. Hwang YW, Jurnak F, Miller DL. 1989. In The Guanine-Nucleotide Binding Proteins: Common Structural and Functional Properties, ed. L Bosch, B Kraal, A Parmeggiani, pp. 77-85. New York: Plenum
109. Polakis P, McCormick F. 1993. J. Biol. Chem. 268:9157-60
110. Marshall M. 1995. Mol. Reprod. Dev. 42:493-99
111. Cook SJ, Rubinfeld B, Albert I, Mc-Cormick F. 1993. EMBO J. 12:3475-85
112. Emerson SD, Madison VS, Palermo RE, Waugh DS, Scheffler JE, et al. 1995. Biochemistry 34:6911-18
113. Block C, Janknecht R, Herrmann C, Nassar N, Wittinghofer A. 1996. Nat. Struct. Biol. 3:244-51
114. Sprang ST. 1995. Structure 3:641-43
115. Wittinghofer A, Nassar N. 1996. Trends Biochem. Sci. 21:488-91
116. 109c. Scheffzek K, Lautwein A, Kabsch W, Ahmadian MR, Wittinghofer A. 1996. Nature 384:591-96
117. Berlot CH, Bourne HR. 1992. Cell 68:911-22
118. Itoh H, Gilman AG. 1991. J. Biol. Chem. 266:16226-31
119. Rarick H, Artemyev NO, Hamm HE. 1992. Science 256:1031-33
120. Faurobert E, Otto-Bruc A, Chardin P, Chabre M. 1993. EMBO J. 12:4191-98
121. Skiba NP, Bae H, Hamm HE. 1996. J. Biol. Chem. 271:413-24
122. Hepler JR, Biddlecome GH, Kleuss C, Camp LA, Hofmann SL, et al. 1996. J. Biol. Chem. 271:496-504
123. Mittal R, Erickson JW, Cerione RA. 1996. Science 271:1413-16
124. Phillips WJ, Cerione RA. 1986. J. Biol. Chem. 263:15498-505
125. Fung BK-K, Nash CR. 1983. J. Biol. Chem. 258:10503-10
126. Hurley JB, Simon MI, Teplow DB, Robishaw JD, Gilman AG. 1984. Science 226:860-62
127. Nakamura S-I, Rodbell M. 1991. Proc. Natl. Acad. Sci. USA 88:7150-54
128. Vaillancourt RR, Dhanasekaran N, Johnson GL, Ruoho AE. 1990. Proc. Natl. Acad. Sci. USA 87:3645-49
129. Vaillancourt RR, Dhanasekaran N, Ruoho AE. 1995. Biochem. J. 311:987-93
130. Rodbell M. 1992. Curr. Top. Cell. Regul. 32:1-47
131. Bourne HR. 1995. Science 270:933-34
132. Neubig RR. 1994. FASEB J. 8:939-46
133. Lisanti MP, Scherer PE, Tang Z, Sargiacomo M. 1994. Trends Cell Biol. 4:231-35
134. Temeles GL, Gibbs JB, D'Alonzo JS, Sigal IS, Scolnick EM. 1985. Nature 313:700-3
135. Kalbitzer HR, Goody RS, Wittinghofer A. 1984. Eur. J. Biochem. 141:591-97
136. Webb MR, Eccleston JF. 1981. J. Biol. Chem. 256:7734-37
137. Eccleston JF, Webb MR. 1982. J. Biol. Chem. 257:5046-49
138. Feuerstein J, Goody RS, Webb MR. 1989. J. Biol. Chem. 264:6188-90
139. Der CJ, Finkel T, Cooper GM. 1986. Cell 44:167-76
140. Vogel US, Dixon RAF, Schaber MD, Diehl RE, Marshall MS, et al. 1988. Nature 335:90-93
141. Graziano MP, Gilman AG. 1989 J. Biol. Chem. 264:15475-82
142. Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, et al. 1990. Science 249:655-59
143. Frech M, Darden TA, Pedersen LG, Foley CK, Charifson PS, et al. 1994. Biochemistry 33:3237-44
144. Langen R, Schweins T, Warshel A. 1992. Biochemistry 31:8691-96
145. Chung H-H, Benson DR, Schultz PG. 1993. Science 259:806-9
146. Kleuss C, Raw AS, Lee E, Sprang SR, Gilman AG. 1994. Proc. Natl. Acad. Sci. USA 91:9828-31
147. Schweins T, Langen R, Warshel A. 1994. Nat. Struct. Biol. 1:476-84
148. Schweins T, Geyer M, Scheffzek K, Warshel A, Kalbitzer HR, Wittinghofer A. 1995. Nat. Struct. Biol. 2:36-44
149. Sternweis PC, Gilman AG. 1982. Proc. Natl. Acad. Sci. USA 79:4888-91
150. Bigay J, Deterre P, Pfister C, Chabre M. 1985. FEBS Lett. 191:181-85
151. Antonny B, Chabre M. 1992. J. Biol. Chem. 267:6710-18
152. Martin RB. 1996. Coord. Chem. Rev. 141:23-42
153. Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. 1994. Nature 372:276-79
154. Cassel D, Selinger Z. 1977. Proc. Natl. Acad. Sci. USA 74:3307-11
155. Kahn RA. 1991. J. Biol. Chem. 266: 15595-97
156. Kraal B, de Graaf MJ, Mesters JR, van Hoof PJM, Jaacquet E, Parmeggiani A. 1990. Eur. J. Biochem. 192:305-9
157. Codina J, Birnbaumer L. 1994. J. Biol. Chem. 269:29339-42
158. Rensland H, Lautwein A, Wittinghofer A, Goody RS. 1991. Biochemistry 30:11181-85
159. Cool RH, Parmeggiani A. 1991. Biochemistry 30:362-66
160. Maegley KA, Admiraal SJ, Herschlag D. 1996. Proc. Natl. Acad. Sci. USA 93:8160-66
161. Trahey M, McCormick F. 1987. Science 238:542-45
162. Gideon P, John J, Frech M, Lautwein A, Clark R, et al. 1992. Mol. Cell. Biol. 12:2050-56
163. Eccleston JF, Moore KJM, Morgan L, Skinner RH, Lowe PN. 1993. J. Biol. Chem. 268:27012-19
164. Mittal R, Ahmadian MH, Goody RS, Wittinghofer A. 1996. Science 273:115-17
165. Skinner RH, Bradley S, Brown AL, Johnson NJE, Rhodes S, et al. 1991. J. Biol. Chem. 266:14163-66
166. Musacchio A, Cantley LC, Harrison SC. 1996. Proc. Natl. Acad. Sci. USA 93:14373-78
167. Boguski MS, McCormick. 1993. Nature 366:643-54
168. Berstein G, Blank JL, Jhon D-Y, Exton JH, Rhee SG, Ross EM. 1992. Cell 70:411-18
169. Biddlecome GH, Berstein G, Ross EM. 1996. J. Biol. Chem. 271:7999-8007
170. Arshavsky VY, Dumke CL, Zhu Y, Artemyev NO, Skiba NP, et al. 1994. J. Biol. Chem. 269:19882-87
171. Ross EM. 1996. Recent Prog. Horm. Res. 50:207-21
172. Druey KM, Blumer KJ, Kang VH, Kehrl JH. 1996. Nature 379:742-46
173. Dohlman HG, Song JP, Ma D, Courchesne WE, Thomer J. 1995. Mol. Cell. Biol. 16:5194-209
174. Koelle MR, Horvitz HR. 1996. Cell 84:115-25
175. De Vries L, Mousli M, Wurmser A, Farquhar MG. 1995. Proc. Natl. Acad. Sci. USA 92:11916-20
176. Berman DM, Wilke TM, Gilman AG. 1996. Cell 86:1-20
177. Watson N, Linder ME, Druey KM, Kehrl JH, Blumer KJ. 1996. Nature 383:172-75
178. Hunt TW, Fields TA, Casey PJ, Peralta EG. 1996. Nature 383:175-77
179. Berman DM, Kozasa T, Gilman AG. 1996. J. Biol. Chem. 271:27209-12
180. Clapham DE, Neer EJ. 1993. Nature 365:403-6
181. Sternweis PC. 1994. Curr. Opin. Cell Biol. 6:198-203
182. Neer EJ. 1995. Cell 80:249-57
183. Watson AJ, Katz A, Simon MI. 1994. J. Biol. Chem. 269:22150-56
184. Ray K, Kunsch C, Bonner LM, Robishaw JD. 1995. J. Biol. Chem. 270:21765-71
185. Hurley JB, Fong HKW, Teplow DB, Dreyer WJ, Simon MI. 1984. Proc. Natl. Acad. Sci. USA 81:6948-52
186. Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG. 1994. J. Biol. Chem. 269:4388-95
187. Iñiguez-Lluhi JA, Simon MI, Robishaw JD, Gilman AG. 1992. J. Biol. Chem. 267:23409-17
188. Schmidt CJ, Neer EJ. 1991. J. Biol. Chem. 266:4538-44
189. Robishaw JD, Kalman VK, Proulx KL. 1992. Biochem. J. 286:677-80
190. Higgins JB, Casey PJ. 1994. J. Biol. Chem. 269:9067-72
191. Schmidt CJ, Thomas TC, Levine MA, Neer EJ. 1992. J. Biol. Chem. 267:13807-10
192. Pronin AN, Gautam N. 1992. Proc. Natl. Acad. Sci. USA 89:6220-24
193. Graf R, Mattera R, Codina J, Evans T, Ho Y-K, Estes MK, Bimbaumer L. 1992. Eur. J. Biochem. 210:609-19
194. Smrcka AV, Sternweis PC. 1993. J. Biol. Chem. 268:9667-74
195. Wickman KD, Iñiguez-Lluhi JA, Davenport PA, Taussig R, Krapivinsky GB, et al. 1994. Nature 368:255-57
196. Wall MA, Coleman DE, Lee E, Iñiguez-Lluhi JA, Posner BA, et al. 1995. Cell 83:1047-58
197. Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. 1996. Nature 379:369-74
198. Murzin AG. 1992. Proteins 14:191-201
199. Fong HKW, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, et al. 1986. Proc. Natl. Acad. Sci. USA 83:2162-66
200. Simon MI, Strathmann MP, Gautam N. 1991. Science 252:802-8
201. Neer EJ, Schmidt CJ, Nambudripad R, Smith TF. 1994. Nature 371:297-300
202. Lupas AN, Lupas JM, Stock JB. 1992. FEBS Lett. 314:105-8
203. Garritsen A, van Galen PJM, Simonds WF. 1993. Proc. Natl. Acad. Sci. USA 90:7706-10
204. Bubis J, Khorana HG. 1990. J. Biol. Chem. 265:12995-99
205. Garcia-Higuera I, Thomas TC, Yi F, Neer EJ. 1996. J. Biol. Chem. 271:528-35
206. Marin EP, Neubig RR. 1995. Biochem. J. 309:377-80
207. Garritsen A, Simonds WF. 1994. J. Biol. Chem. 269:24418-23
208. Katz A, Simon MI. 1995. Proc. Natl. Acad. Sci. USA 92:1998-2002
209. Spring DJ, Neer EJ. 1994. J. Biol. Chem. 269:22882-86
210. Lee CH, Murakami T, Simonds WF. 1995. J. Biol. Chem. 270:8779-84
211. Navon SE, Fung BK-K. 1987. J. Biol. Chem. 262:15746-51
212. Neer EJ, Pulsifer L, Wolf LG. 1988. J. Biol. Chem. 263:8896-9000
213. Graf R, Mattera R, Codina J, Estes M, Birnbaumer L. 1992. J. Biol. Chem. 267:24307-14
214. Journot L, Pantaloni C, Bockaert J, Audigier Y. 1991. J. Biol. Chem. 266:9009-15
215. Kozasa T, Gilman AG. 1996. J. Biol. Chem. 12562:12562-67
216. Fields TA, Casey PJ. 1995. J. Biol. Chem. 270:23119-25
217. Mumby SM, Heukeroth RO, Gordon JI, Gilman AG. 1990. Proc. Natl. Acad. Sci. USA 87:728-32
218. Linder ME, Pang IH, Duronio RJ, Gordon JI, Sternweis PC, Gilman AG. 1991. J. Biol. Chem. 266:4654-59
219. Cerione RA, Staniszewski C, Benovic JL, Lefkowitz RJ, Caron MG, et al. 1985. J. Biol. Chem. 260:1493-1500
220. Rahmatullah M, Robishaw JD. 1994. J. Biol. Chem. 269:3574-80
221. Rahmatullah M, Ginnan R, Robishaw JD. 1995. J. Biol. Chem. 270:2946-51
222. Whiteway M, Clark KL, Leberer E, Dignard D, Thomas DY. 1994. Mol. Cell. Biol. 14:3223-29
223. Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm H, Sigler PB. 1996. Nature 379:311
224. Thomas TC, Schmidt CJ, Neer EJ. 1993. Proc. Natl. Acad. Sci. USA 90:10295-99
225. Thomas TC, Sladek T, Yi F, Smith T, Neer EJ. 1993. Biochemistry 32:8628-35
226. Schalk I, Zeng K, Wu S-K, Stura E, Matteson J, et al. 1996. Nature 38:42-48
227. Wu S-K, Zeng K, Wilson IA, Balch WE. 1996. Trends Biochem. Sci. 21:472-76
228. Overbeck AF, Brtva TR, Cox AD, Graham SM, Huff SY, et al. 1995. Mol. Reprod. Dev. 42:468-76
229. Yu H, Schreiber SL. 1995. Nature 376:788-90
230. Strader CD, Fong TM, Tota MR, Underwood D, Dixon RAF. 1994. Annu. Rev. Biochem. 63:101-32
231. Phillips WJ, Cerione RA. 1992. J. Biol. Chem. 267:17032-39
232. Asano T, Katada T, Gilman AG, Ross EM. 1984. J. Biol. Chem. 259:9351-54
233. Watson S, Arkinstall S. 1996. The G-Protein Linked Receptor Factsbook, pp. 2-295. London: Academic
234. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, Wittig B. 1991. Nature 353:43-48
235. Kleuss C, Scherubl H, Hescheler J, Schultz G, Wittig B. 1992. Nature 358: 424-26
236. Kleuss C, Scherubl H, Hescheler J, Schultz G, Wittig B. 1993. Science 259:832-34
237. Kisselev O, Gautam N. 1993. J. Biol. Chem. 268:24519-22
238. Kisselev OG, Ermolaeva MV, Gautam N. 1994. J. Biol. Chem. 269:21399-402
239. Taylor JM, Neubig RR. 1994. Cell. Signal. 6:841-49
240. Higashijima T, Burnier J, Ross EM. 1990. J. Biol. Chem. 265:14176-86
241. Wade SM, Dalman HM, Yang S-Z, Neubig RR. 1994. Mol. Pharmacol. 45:1191-97
242. Conklin BR, Bourne HR. 1993. Cell 73:631-41
243. Rasenick MM, Watanabe M, Lazarevic MB, Hatta S, Hamm HE. 1994. J. Biol. Chem. 269:21519-25
244. Iiri T, Herzmark P, Nakamoto JM, Van Dop C, Bourne HR. 1994. Nature 371:164-68
245. Taylor JM, Jacob-Mosier GG, Lawton RG, Remmers AE, Neubig RR. 1994. J. Biol. Chem. 269:27618-24
246. Deleted in proof
247. Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R. 1996. Nature 379:511-18
248. Kraulis PJ. 1991. J. Appl. Cryst. 24:946-50
249. Bernstein FC, Koetzle TF, Williams JB, Meyer EF Jr, Brice MD, et al. 1977. J. Mol. Biol. 112:535-42