N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains

Molecular and Cellular Biology

Volumn 18, Issue 2, 1998, Pages 771-778

  Qian, Xiaolan ^a   Vass, William C ^a   Papageorge, Alex G ^a   Anborgh, Pieter H ^a   Lowy, Douglas R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL STRAIN 3T3; CONFORMATIONAL TRANSITION; GENE DELETION; GENETIC ENGINEERING; GROWTH REGULATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

EID: 0031929680     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.2.771     Document Type: Article

References (43)

1. Aronheim, A., D. Engelberg, N. X. Li, N. Al-Alawi, J. Schlessinger, and M. Karin. 1994. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78:949-961.
2. Avruch, J., X. F. Zhang, and J. M. Kyriakis. 1994. Rat meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:279-283.
3. Bar-Sagi, D. 1994. The Sos (son of sevenless) protein. Trends Endocrinol. Metab. 5:165-169.
4. Batzer, A. G., D. Rotin, J. M. Urena, E. Y. Skolinik, and J. Schlessinger. 1994. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14:5192-5201.
5. Bonfini, L., C. A. Karlovich, C. Dasgupta, and U. Banerjee. 1992. The son of sevenless gene product - a putative activator of Ras. Science 255:603-606.
6. Bowtell, D., P. Fu, M. Simon, and P. Senior. 1992. Identification of murine homologues of the Drosophila son of sevenless gene - potential activators of ras. Proc. Natl. Acad. Sci. USA 89:6511-6515.
7. Buday, L., and J. Downward. 1993. Epidermal growth factor regulates p21(Ras) through the formation of a complex of receptor, GRB2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611-620.
8. Byrne, J. L., H. F. Paterson, and C. J. Marshall. 1996. p21Ras activation by the guaninc nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene 13:2055-2065.
9. Cen, H., A. G. Papageorge, W. C. Vass, K. Zhang, and D. R. Lowy. 1993. Regulated and constitutive activity by CDC25(Mm) (GRF), a Ras-specific exchange factor. Mol. Cell. Biol. 13:7718-7724.
10. Cerione, R. A., and Y. Zheng. 1996. The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8:216-222.
11. Chardin, P., J. H. Camonis, N. W. Gale, L. Van Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human sos1 - a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338-1343.
12. Chen, R. H., G. S. Corbalan, and D. Bar-Sagi. 1997. The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J. 16: 1351-1359.
13. Clark, S. G., M. J. Stern, and H. R. Horvitz. 1992. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356:340-344.
14. Crespo, P., N. Xu, J. L. Daniotti, J. Troppmair, U. R. Rapp, and J. S. Gutkind. 1994. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J. Biol. Chem. 269:21103-21109.
15. DeClue, J. E., W. C. Vass, A. G. Papageorge, D. R. Lowy, and B. M. Willumsen. 1991. Inhibition of cell growth by lovastatin is independent of ras function. Cancer Res. 51:712-717.
16. Downward, J. 1996. Control of ras activation. Cancer Surv. 27:87-100.
17. Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in ryrosine kinase signal transduction and transformation. Nature 363:45-51.
18. Freshney, N. W., S. D. Goonesekera, and L. A. Feig. 1997. Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain. FEBS Lett. 407:111-115.
19. Gale, N. W., S. Kaplan, E. J. Lowenstein, J. Schlessinger, and D. Bar-Sagi. 1993. Grb2 mediates the EGF-Dependent activation of guanine nucleotide exchange on ras. Nature 363:88-92.
20. Hart, M. J., A. Eva, T. Evans, S. A. Aaronson, and R. A. Cerione. 1991. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354:311-314.
21. Hart, M. J., A. Eva, D. Zangrilli, S. A. Aaronson, T. Evans, R. A. Cerione, and Y. Zheng. 1994. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269:62-65.
22. Herrmann, C., and N. Nassar. 1996. Ras and its effectors. Prog. Biophys. Mol. Biol. 66:1-41.
23. Karlovich, C. A., L. Bonfini, L. McCollam, R. D. Rogge, A. Daga, M. P. Czech, and U. Banerjee. 1995. In vivo functional analysis of the Ras exchange factor son of sevenless. Science 268:576-579.
24. Katz, M. E., and F. McCormick. 1997. Signal transaction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7:75-79.
25. Li, N., A. Batzer, R. Daly, V. Yajnik, E. Skolnik, P. Chardin, D. Bar-Sag, B. Margolis, and J. Schlessinger. 1993. Guanine-nucleotide-releasing factor hSos1 hinds to Grb2 and links receptor tyrosinc kinases to ras signalling. Nature 363:85-88.
26. Li, T., S. Tsukada, A. Satterthwaite, M. H. Havlik, H. Park, K. Takatsu, and O. N. Witte. 1995. Activation of Bruton's tyrosine kinasc (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity 2:451-460.
27. Lowy, D. R., and B. M. Willumsen. 1993. Function and regulation of Ras. Annu. Rev. Biochem. 62:851-891.
28. Marshall, C. J. 1996. Ras effectors. Curr. Opin. Cell Biol. 8:197-204.
29. McCollam, L., L. Bonfini, C. A. Karlovich, B. R. Conway, L. M. Kozma, U. Banerjee, and M. P. Czech. 1995. Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J. Biol. Chem. 270:15954-15957.
30. Migliaccio, E., S. Mele, A. E. Salcini, G. Pelicci, K. M. Lai, F. G. Superti, T. Pawson, F. P. Di, L. Lanfrancone, and P. G. Pelicci. 1997. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 16:706-716.
31. Nielsen, K. H., A. G. Papageorge, W. C. Vass, B. M. Willumsen, and D. R. Lowy. 1997. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol. Cell. Biol. 17:7132-7138.
32. Niman, H. L., R. A. Houghten, L. E. Walker, R. A. Reisfeld, I. A. Wilson, J. M. Hogle, and R. A. Lernor. 1983. Generation of protein-reactive anti-bodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc. Natl. Acad. Sci. USA 80:4949-4953.
33. Paterson, H. F., J. W. Savopoulos, O. Perisic, R. Cheung, M. V. Ellis, R. L. Williams, and M. Katan. 1995. Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane. Biochem. J. 312:661-666.
34. Pitcher, J. A., K. Touhara, E. S. Payner, and R. J. Lefkowitz. 1995 Pleckstrin homology domain-mediated membrane association and activation of the β-adreergic receptor kinase requires coordinate interaction wiht Gβγ subunits and lipid. J. Biol. Chem. 270:11707-11710.
35. Quilliam, L. A., S. Y. Huff, K. M. Rabun, W. Wei, W. Park, D. Broek, and C. J. Der. 1994. Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proc. Natl. Acad. Sci. USA 91:8512-8516.
36. Shaw, G. 1996. The pleckstrin homology domain: an intriguing multifunctional protein module. Bioessays 18:35-46.
37. Simon, M. A., D. D. L. Bowtell, G. S. Dodson, T. R. Laverty, and G. M. Rubin. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67:701-716.
38. Uetsuki, T., A. Naito, S. Nagata, and Y. Kaziro. 1989. Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1α. J. Biol. Chem. 264:5791-5798.
39. Vihinen, M., M. J. Zvelebil, Q. Zhu, R. A. Brooimans, H. D. Ochs, B. J. Zegers, L. Nilsson, M. D. Waterfield, and C. I. Smith. 1995. Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia. Biochemistry 34:1475-1481.
40. Wang, W., E. M. Fisher, Q. Jia, J. M. Dunn, E. Porfiri, J. Downward, and S. E. Egan. 1995. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nat. Genet. 10:294-300.
41. H. Mol. Cell. Biol. 9:6026-6033.
42. Yenush, L., K. J. Makati, H. J. Smith, O. Ishibashi, M. J. Myers, and M. F. White. 1996. The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. J. Biol. Chem. 271:24300-24306.
43. Zhang, K., A. G. Papageorge, and D. R. Lowy. 1992. Mechanistic aspects of signalling through Ras in NIH 3T3 cells. Science 257:671-674.