Linking Rap to cell adhesion

Current Opinion in Cell Biology

Volumn 17, Issue 2, 2005, Pages 123-128

  Bos, Johannes L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AFADIN; ARAP 3 PROTEIN; CADHERIN; GUANINE NUCLEOTIDE; GUANOSINE TRIPHOSPHATASE; INTEGRIN; PDZ PROTEIN; RAC PROTEIN; RAP PROTEIN; RAPL PROTEIN; RIAM PROTEIN; UNCLASSIFIED DRUG; VAV PROTEIN;

CELL ADHESION; CELL JUNCTION; CELL POLARITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 15044359236     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2005.02.009     Document Type: Review

References (40)

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11. ••] are the first papers to show that Rap1 regulates E-cadherin-mediated cell junction formation. This paper demonstrates that inhibition of Rap1 inhibits cell surface expression of E-cadherin.
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16. •].
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25. ••] show that RapL is an effector of Rap1, mediating integrin clustering in T-cells. It describes knockout mice of RapL that show a defect in T- and B-cell migration and a defect in the homing of T- and B-cells, as well as dendritic cells, to peripheral organs.
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40. J.C. Schwamborn, and A.W. Puschel The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity Nat Neurosci 7 2004 923 929 This study shows that the recruitment of Rap1 to a developing neurite determines the fate of this neurite to become an axon. This demonstrates for the first time that Rap1 is a crucial determinant of cell polarity in mammalian cells.