A Novel Bifunctional Phospholipase C That Is Regulated by Gα 12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2758-2765

  Lopez, Isabel ^a   Mak, Eric C ^a   Ding, Jirong ^a   Hamm, Heidi E ^a   Lomasney, Jon W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; HYDROLYSIS; MUTAGENESIS;

BIFUNCTIONAL ENZYMES;

ENZYMES;

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA12; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C EPSILON; RAS PROTEIN; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PLCE1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; SECOND MESSENGER; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; SEQUENCE HOMOLOGY;

ANIMALIA; EUKARYOTA;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C; RAS PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0035951882     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008119200     Document Type: Article

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