Beyond the somatopause: Growth hormone deficiency in adults over the age of 60 years

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 460-465

  Toogood, Andrew A ^a   O'Neill, Paul A ^b   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ATENOLOL; BENDROFLUMETHIAZIDE; CALCIUM CARBONATE; DICLOFENAC; DIGOXIN; DIPYRIDAMOLE; ENALAPRIL; NIFEDIPINE; OMEPRAZOLE; OXYBUTYNIN; QUININE; RANITIDINE; WARFARIN;

ADULT; AGED; AGING; ARTICLE; BODY COMPOSITION; BONE MINERAL; CLINICAL ARTICLE; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; HYPOPHYSIS DISEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MENOPAUSE; PRIORITY JOURNAL; WELLBEING;

AGED; AGED, 80 AND OVER; AGING; ARGININE; BODY MASS INDEX; FEMALE; GROWTH HORMONE; HUMANS; HYPOTHALAMIC DISEASES; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PITUITARY DISEASES; REFERENCE VALUES;

EID: 0030062657     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.460     Document Type: Article

References (34)

1. Cuneo RC, Salomon F, McGauley GA, Sönksen PH. 1992 The growth hormone deficiency syndrome in adults. Clin Endocrinol. 37:387-397.
2. de Boer H, Blok G-J, Popp-Snijders C, van der Veen E. 1994 Diagnosis of growth hormone deficiency in adults [Letter]. Lancet. 343:1645-1646.
3. Weissberger AJ, Verikiou K, Sönksen PH. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 344:483.
4. Holmes SJ. 1995 Growth hormone replacement in adults with growth hormone deficiency. MD Thesis. London: University of London; 141-152.
5. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KKY. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 343:1064-1068.
6. Salomon F, Cuneo RC, Hesp R, Sönksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
7. Bengtsson B-Å, Edén S, Lönn L, et al. 1993 Treatment of adults with growth hormone deficiency with recombinant human GH. J Clin Endocrinol Metab. 76:309-317.
8. McCauley GA. 1989 Quality of life assessment before and after growth hormone treatment in adults with growth hormone deficiency. Acta Paediatr Scand. 356(Suppl):70-72.
9. Caidahl K, Eden S, Bengtsson B-Å. 1994 Cardiovascular and renal effects of growth hormone. Clin Endocrinol (Oxf). 40:393-400.
10. O'Halloran DJ, Tsatsoulis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM. 1993 Increased bone density after recombinant human growth hormone therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab. 76: 1344-1348.
11. Finklestein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L. 1972 Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab. 35:665-670.
12. Carlson HE, Gillin JC, Gorden P, Snyder F. 1972 Absence of sleep related growth hormone peaks in aged normal subjects and in acromegaly. J Clin Endocrinol Metab. 34:1102-1105.
13. Dudl RJ, Ensinck JW, Palmer HE, Williams RH. 1973 Effect of age on growth hormone secretion in man. J Clin Endocrinol Metab. 37:11-16.
14. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. 1981 Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest. 67:1361-1369.
15. Prinz PN, Weitzman ED, Cunningham GR, Karacan I. 1983 Plasma growth hormone during sleep in young and aged men. J Gerontol. 38:519-524.
16. Shibasaki T, Shizume K, Nakahara M, et al. 1984 Age related changes in plasma growth hormone response to growth hormone releasing factor in man. J Clin Endocrinol Metab. 58:212-214.
17. Florini JR, Prinz PN, Vitiello MV, Hintz RL. 1985 Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone. J Gerontol. 40:2-7.
18. Zadik Z, Chalew SA, McCarter RJ, Meistas M, Kowarski AA. 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab. 60:513-516.
19. Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
20. Iranmanesh A, Lizarralde G, Veldhuis JD. 1991 Age and relative obesity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 73:1081-1088.
21. Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G. 1991 Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 72:51-59.
22. Rudman D. 1985 Growth hormone, body composition and aging. J Am Geriatr Soc. 33:800-807.
23. Sizonenko PC, Rabinovitch A, Schneider P, Paunier L, Wollheim CB, Zahnd G. 1975 Plasma growth hormone, insulin and glucagon responses to arginine infusion in children and adolescents with idiopathic short stature, isolated growth hormone deficiency, panhypopituitarism and anorexia nervosa. Pediatr Res. 9:733-738.
24. Ghigo E, Goffi S, Nicolosi M, et al. 1990 Growth hormone responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J Clin Endocrinol Metab. 71:1481-1485.
25. Toogood AA, Beardwell CG, Shalet SM. 1994 The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clin Endocrinol (Oxf). 41:511-516.
26. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. 1994 Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol (Oxf). 41:351-357.
27. Kalk WJ, Vinik AI, Pimstone BL, Jackson WP. 1973 Growth hormone responses to insulin hypoglycaemia in the elderly. J Gerontol. 28:431-433.
28. Laron Z, Doron M, Amikam B. 1970 Plasma growth hormone in men and women over 70 years of age. Med Sport. 4:126-131.
29. Muggeo M, Feddele D, Tiengo A, Molinari M, Crepaldi G. 1975 Human growth hormone and cortisol responses to insulin stimulation in ageing. J Gerontol. 30:546-551.
30. Pavlov EP, Harman SM, Merriam GR, Gelato MC, Blackman MR. 1986 Responses of growth hormone and somatomedin-C to GH-releasing hormone in healthy aging men. J Clin Endocrinol Metab. 62:595-600.
31. Lang I, Schernthaner G, Pietschmann P, Kurz R, Stephenson JM, Tempi H. 1987 Effects of sex and age on growth hormone response to growth hormone-releasing hormone in healthy individuals. J Clin Endocrinol Metab. 65:535-540.
32. Zapf J, Walter H, Froesch ER. 1981 Radioimmunological determination of insulin-like growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumour hypoglycaemia. J Clin Invest. 68:1321-1330.
33. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old [see comments]. N Engl J Med. 323:1-6.
34. Cohn L, Feller AG, Draper MW, Rudman IW, Rudman D. 1993 Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-1 concentrations. Clin Endocrinol (Oxf). 39: 417-425.