A single IGF1 allele is a major determinant of small size in dogs

Science

Volumn 316, Issue 5821, 2007, Pages 112-115

  Sutter, Nathan B ^a   Bustamante, Carlos D ^b   Chase, Kevin ^c   Gray, Melissa M ^d   Zhao, Keyan ^e   Zhu, Lan ^b   Padhukasahasram, Badri ^b   Karlins, Eric ^a   Davis, Sean ^a   Jones, Paul G ^f   Quignon, Pascale ^a   Johnson, Gary S ^g   Parker, Heidi G ^a   Fretwell, Neale ^f   Mosher, Dana S ^a   Lawler, Dennis F ^h   Satyaraj, Ebenezer ^h   Nordborg, Magnus ^e   Lark, K Gordon ^c   Wayne, Robert K ^d   Ostrander, Elaine A ^a   more..

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b Plant Breeding and Genetics Section in the School of Integrative Plant Science   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

^g UNIVERSITY OF MISSOURI   (United States)

^h NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN;

ALLELE; BODY SIZE; BREEDING; CANID; GENETIC VARIATION; POLYMORPHISM;

ALLELE; ARTICLE; BODY SIZE; BREED; CHROMOSOME 15; DOG; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; BODY SIZE; BREEDING; DOGS; EXONS; GENOTYPE; HAPLOTYPES; HETEROZYGOTE; INSULIN-LIKE GROWTH FACTOR I; INTRONS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

CANIS FAMILIARIS; VERTEBRATA;

EID: 34147113272     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1137045     Document Type: Article

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29. We thank the hundreds of dog owners who contributed samples; the AKC Canine Health Foundation; S. Hoogstraten-Miller and I. Ginty for assistance at dog shows; P. Cruz for assistance with automated PCR primer designs; S. Kim for analytical assistance, and R. Pelker for assistance with blood serum assays of IGF1. Funded by the National Human Genome Research Institute (E.A.O., N.B.S., E.K., S.D., P.O., H.G.P., and D.S.M.), the NSF (R.K.W.), NIH grant no. 5 T32 HG002536 (M.M.G.), NSF grant 0516310 (C.D.B. and L.Z.), NSF grant DBI 0606461 (B.P.), NIH grant P50 HG002790 (K.Z. and M.N.), and the National Institute of General Medical Sciences 063056, the Judith Chiara Charitable Trust, and the Nestle Purina Company (K.G.L.).