Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

Journal of Clinical Investigation

Volumn 105, Issue 7, 2000, Pages 935-943

  Ogata, Naoshi ^a   Chikazu, Daichi ^a   Kubota, Naoto ^a   Terauchi, Yasuo ^a   Tobe, Kazuyuki ^a   Azuma, Yoshiaki ^b   Ohta, Tomohiro ^b   Kadowaki, Takashi ^a   Nakamura, Kozo ^a   Kawaguchi, Hiroshi ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b TEIJIN LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL CELL; ARTICLE; BONE METABOLISM; BONE TURNOVER; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPENIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 17144438059     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9017     Document Type: Article

References (47)

1. Thomas, D.M., Hards, D.K., Rogers, S.D., Ng, K.W., and Best, J.D. 1997. Insulin and bone, clinical and scientific view. Endocrinol. Metab. N. Am. 4:5-17.
2. Thomas, D.M., Hards, D.K., Rogers, S.D., Ng, K.W., and Best, J.D. 1996. Insulin receptor expression in bone. J. Bone Miner. Res. 11:1312-1320.
3. Canalis, E. 1993. Insulin like growth factors and the local regulation of bone formation. Bone. 14: 273-276.
4. Rosen, C.J., and Donahue, L.R. 1998. Insulin-like growth factors and bone, the osteoporosis connection revisited. Proc. Soc. Exp. Biol. Med. 219:1-7.
5. Buysschaert, M., et al. 1992. Proximal femur density in type I and type II diabetic patients. Diabetes. Metab. 18:32-37.
6. Piepkorn, B., et al. 1997. Bone mineral density and bone metabolism in diabetes mellitus. Horm. Metab. Res. 29:584-591.
7. Krakauer, J.C., McKenna, M.J., Rao, D.S., and Whitehouse, F.W. 1997. Bone mineral density in diabetes. Diabetes Care. 20:1339-1340.
8. Laron, Z., Klinger, B., and Silbergeld, A. 1999. Patients with Laron syndrome have osteopenia/osteoporosis. J. Bone Miner. Res. 14:156-161.
9. Kasuga, M., Karlsson, F.A., and Kahn, C.R. 1982. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science. 215:185-187.
10. Ullrich, A., et al. 1986. Insulin-like growth factor-I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5:2503-2512.
11. Kadowaki, T., et al. 1996. Signal transduction mechanism of insulin and insulin-like growth factor-1. Endocr. J. 43:33-34.
12. Sun, X.J., et al. 1991. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 352:73-77.
13. Sun, X.J., et al. 3995. Role of IRS-2 in insulin and cytokine signalling. Nature. 377:173-177.
14. Tamemoto, H., et al. 1994. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 372:182-186.
15. Araki, E., et al. 1994. Alternative pathway of insulin signaling in mice with targeted disruption of IRS-1 gene. Nature. 372:186-190.
16. Riggs, B.L., and Melton, L.J., III 1986. Involutional osteoporosis. N. Engl. J. Med. 314:1676-1686.
17. Trippel, S.B., Chernausek, S.D., Van Wyk, J.J., Moses, A.C., and Mankin, H.J. 1988. Demonstration of type I and type II somatomedin receptors on bovine growth plate chondrocytes. J. Orthop. Res. 6:817-826.
18. Tobe, K., et al. 1995. Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J. Biol. Chem. 270:5698-5671.
19. Yamauchi, T., et al. 1996. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell Biol. 16:3074-3084.
20. Kaburagi, Y., et al. 1997. Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes. J. Biol. Chem. 272:25839-25844.
21. Sun, X.J., et al. 1997. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol. Endocrinol. 11:251-262.
22. Bruning, J.C., et al. 1997. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol. Cell. Biol. 17:1513-1521.
23. Miyamoto, A., et al. 1998. Establishment and characterization of an immortal macrophage-like cell line inducible to differentiate to osteoclasts. Biochem. Biophys. Res. Commun. 242:703-709.
24. Yasuda, H., et al. 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA. 95:3597-3602.
25. Suda, T., Nakamura, I., Jimi, E., and Takahashi, N. 1997. Regulation of osteoclast function. J. Bone Miner. Res. 12:869-879.
26. Lacey, D.L., et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165-176.
27. Canalis, E., Centrella, V., Burch, W., and McCarthy, T. 1989. Insulin-like growth factor-I mediates selective anabolic effects of parathyroid hormone in bone cultures. J. Clin. Invest. 83:60-65.
28. Pfeilschifter, J., et al. 1995. Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. J. Clin. Invest. 96:767-774.
29. 2α stimulates proliferation of clonal osteoblastic MC3T3-E1 cells by up-regulation of insulin-like growth factor I receptors. J. Biol. Chem. 266:21044-21050.
30. Rosen, C.J., et al. 1997. Circulating and skeletal insulin-like growth factor-I (IGF-1) concentrations in two inbred strains of mice with different bone mineral densities. Bone. 21:217-223.
31. Canalis, E. 1997. Insulin-like growth factors and osteoporosis. Bone. 21:215-216.
32. Reed, B.Y., et al. 1995. Serum IGF-1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. J. Bone Miner. Res. 10:1218-1224.
33. Hough, S., Avioli, L.V., Teitelbaum, S.L., and Fallon, M.D. 1981. Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy. Endocrinology. 108:2228-2234.
34. Haffner, S.M., and Bauer, R.L. 1993. The association of obesity and glucose and insulin concentrations with bone density in premenopausal and postmenopausal women. Metabolism. 42:735-738.
35. Kao, C.H., Tsou, C.T., Chen, C.C., and Wang, S.J. 1993. Bone mineral density in patients with noninsulin-dependent diabetes mellitus by dual photon absorptiometry. Nucl. Med. Commun. 14: 373-377.
36. Van Daele, P.L., et al. 1995. Bone density in non-insulin-dependent diabetes mellitus. Ann. Intern. Med. 122:409-414.
37. Porzio, O., et al. 1999. The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J. Clin. Invest. 104:357-364.
38. Shao, P., and Lazar, A.M. 1999. Modulating nuclear receptor function: may the phos be with you. J. Clin. Invest. 103:1617-1618.
39. Kato, S., et al. 1995. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 270:1491-1494.
40. Kato, S., Kitamoto, T., Masuhiro, Y., and Yanagisawa, J. 1998. Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways. Oncology. 55:5-10.
41. Tremblay, A., Tremblay, G.B., Labrie, F., and Giguere, V. 1999. Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. Mol. Cell. 3: 513-519.
42. Solomon, C., White, J.H., and Kremer, R. 1999. MAP kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylation of human RXR on serine 260. J. Clin. Invest. 103:1729-1735.
43. Mochizuki, H., et al. 1992. Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology. 131:1075-1080.
44. Hill, P.A., Reynolds, J.J., and Meikle, M.C. 1995. Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function. Endocrinology. 136:124-131.
45. Fiorelli, G., et al. 1996. Characterization and function of the receptor for IGF-I in human preosteoclastic cells. Bone. 18:269-276.
46. Hou, P., Sato, T., Hofstetter, W., and Foged, N.T. 1997. Identification and characterization of the insulin-like growth factor-I receptor in mature rabbit osteoclasts. J. Bone Miner Res. 12:534-540.
47. Thomas, D.M., et al. 1998. Insulin receptor expression in primary and cultured osteoclast-like cells. Bone. 23:181-186.