A growth hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin

Endocrinology

Volumn 137, Issue 11, 1996, Pages 5163-5165

  Chen, Nian Yi ^a   Chen, Wen Y ^a   Kopchick, John J ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE DERIVATIVE; HEMOGLOBIN A1C; STREPTOZOCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GLOMERULOSCLEROSIS; GROWTH HORMONE BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE;

EID: 0029843379     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895392     Document Type: Article

References (9)

1. Doi T, Hattori M, Agodoa LYC, Sato T, Yoshida H, Striker LJ, Striker GE 1990 Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia. Lab Invest 63:204-212
2. Vora J, owens R, Luzio S, Atiea J, Ryder R, Hayes TM 1987 Renal response to intervenors somatostatin in insulin-dependent diabetic patients and normal subjects. J Clin Endocrin Metab 64:975-979
3. Copeland KR, Yatscoff RW, Thliveris JA, Mehta A, Penner B 1987 Nonenzymatic glycation and altered renal structure and function in the diabetic rat. Kidney Int 32:664-670
4. Trueb B, Fluckiger R, Winterhalter KH 1984 Nonenzymatic glycosylation of basement membrane collagen in diabetes mellitus. Collagen Rel Res 4:2399-2251
5. Chen N, Chen WY, Bellush L, Yang C-W, Striker LJ, Striker, GE, Kopchick JJ 1995 Effects of STZ treatment in GH and GH-antagonist transgenic mice. Endocrinology 136: 660-667
6. Chen WY, Chen N-Y, Yun J, Wagner T, Kopchick JJ 1994 In vitro and in vivo studies of antagonistic effects of human growth hormone analogs. J Bio Chem 269:15892-15897
7. Davidson MB 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocri Rew 8:115-131
8. O'shea MH, Layish DT 1992 Growth hormone and the kidney: a case presentation and review of the literature. J Am Soc Nep
9. Peterson ME, Taylor RS, Greco DS, Nelson RW, Randolph JF, Foodman MS, Moroff SD, Morrison SA, Lothrop CD 1990 Acromegaly in 14 cats. J Veterinary Internal Medicine 4:192-201