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Volumn 28, Issue 5 SUPPL, 2005, Pages 19-22

Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models

Author keywords

Gene deletion mice models; IGF I; IGF I receptor; Transgenic mice

Indexed keywords

FATTY ACID; FIBRIC ACID DERIVATIVE; GROWTH HORMONE; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; TRIACYLGLYCEROL; SOMATOMEDIN C RECEPTOR;

EID: 27744438744     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (37)

References (14)
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  • 4
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    • Circulating levels of IGF-I directly regulate bone growth and density
    • Yakar S, Rosen CJ, Beamer WG, et al. Circulating levels of IGF-I directly regulate bone growth and density. J Clin Invest 2002, 110: 771-81.
    • (2002) J Clin Invest , vol.110 , pp. 771-781
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  • 5
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    • Liver-specific IGF-I gene deletion leads to muscle insulin insensitivity
    • Yakar S, Liu JL, Fernandez AM, et al. Liver-specific IGF-I gene deletion leads to muscle insulin insensitivity. Diabetes 2001, 50: 1110-8.
    • (2001) Diabetes , vol.50 , pp. 1110-1118
    • Yakar, S.1    Liu, J.L.2    Fernandez, A.M.3
  • 6
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    • Inhibition of growth hormone action improves insulin sensitivity in liver IGF-I-deficient mice
    • Yakar S, Setser J, Zhao H, et al. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-I-deficient mice. J Clin Invest 2004, 113: 96-105.
    • (2004) J Clin Invest , vol.113 , pp. 96-105
    • Yakar, S.1    Setser, J.2    Zhao, H.3
  • 8
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    • Circulating IGF-I levels regulate colon cancer growth and metastasis
    • Wu Y, Yakar S, Zhao H, et al. Circulating IGF-I levels regulate colon cancer growth and metastasis. Cancer Res 2002, 62: 1030-5.
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    • Wu, Y.1    Yakar, S.2    Zhao, H.3
  • 9
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    • Reduced circulating IGF-I levels delays the onset of chemically- and genetically-induced mammary tumors
    • Wu Y, Cui K, Miyoshi K, et al. Reduced circulating IGF-I levels delays the onset of chemically- and genetically-induced mammary tumors. Cancer Res 2004, 63: 4348.
    • (2004) Cancer Res , vol.63 , pp. 4348
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3
  • 10
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    • Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)
    • Kato H, Faria TN, Stannard B, Roberts CT Jr, LeRoith D. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J Biol Chem 1993, 268: 2655-61.
    • (1993) J Biol Chem , vol.268 , pp. 2655-2661
    • Kato, H.1    Faria, T.N.2    Stannard, B.3    Roberts Jr, C.T.4    LeRoith, D.5
  • 11
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    • Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
    • Fernandez AM, Kim JK, Yakar S, et al. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 15:1926-34.
    • (1926) Genes Dev , vol.15
    • Fernandez, A.M.1    Kim, J.K.2    Yakar, S.3
  • 12
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    • Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis
    • Kim H, Haluzik M, Asghar Z, et al. Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes, 2003, 52: 1770-8.
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  • 13
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    • Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidemia without affecting the hyperglycemia in a transgenic model of type 2 diabetes
    • Kim H, Haluzik M, Gavrilova O, et al. Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidemia without affecting the hyperglycemia in a transgenic model of type 2 diabetes. Diabetologia 2004, 47: 2215-25.
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    • Kim, H.1    Haluzik, M.2    Gavrilova, O.3
  • 14
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    • Zhao, H.1    Yakar, S.2    Gavrilova, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.