Mitochondrial oxidant generation and oxidative damage in ames dwarf and GH transgenic mice

Journal of the American Aging Association

Volumn 24, Issue 3, 2001, Pages 85-96

  Brown Borg, Holly ^a   Johnson, W Thomas ^b   Rakoczy, Sharlene ^a   Romanick, Mark ^a  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MALONALDEHYDE; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; DWARFISM; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; LIFESPAN; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0035728328     PISSN: 01619152     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11357-001-0012-6     Document Type: Article

References (89)

1. The aging process
2. The free radical theory of aging revisited: A critique and a suggested disease-specific theory
3. Mitochondrial oxidative damage, hydrogen peroxide release, and aging
4. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
5. Oxidants, antioxidants and the degenerative diseases of aging
6. Oxygen toxicity, oxygen radicals, transition metals and disease
7. Oxidative stress and mitochondrial DNA mutations in human aging
8. Hydrogen peroxide production by liver mitochondria in different species
9. Comparison of mitochondrial prooxidant generation and antioxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential
10. Oxidative stress, caloric restriction, and aging
11. Reversible effects of long-term caloric restriction on protein oxidative damage
12. The retardation of aging by caloric restriction: Studies in rodents and primates
13. Dwarf mice and the aging process
14. Catalase expression in delayed and premature aging mouse models
15. Are there genes for aging?
16. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
17. Is the Laron mouse an accurate model of Laron Syndrome?
18. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
19. Premature aging in transgenic mice expressing growth hormone genes
20. Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice
21. Effects of chronic exposure to bovine growth hormone (bGH) on the hypothalamic-pituitary axis in transgenic mice: Relationship to the degree of expression of the PEPCK.bGH hybrid gene
22. Expression of human, but not bovine, growth hormone genes promotes development of mammary tumors in transgenic mice
23. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
24. Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria
25. Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA
26. Biomarkers of free radical damage applications in experimental animals and in humans
27. Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by HPLC with electrochemical detection
28. Oxidative damage and mitochondrial decay in aging
29. Chemistry and biochemistry of 4-hydroxynoneal, malonaldehyde and related aldehydes
30. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
31. Antioxidative mechanisms and plasma growth hormone levels: Potential relationship in the aging process
32. Mitochondrial diseases in man and mouse
33. Mitochondrial disease in superoxide dismutase 2 mutant mice
34. Hormones and oxidative stress
35. Influence of age, exercise, and dietary restriction on oxidative stress in rats
36. Relationship between plasma growth hormone, antioxidants and oxidative damage in premature and delayed aging mice
37. Low body temperature in long-lived Ames dwarf mice during rest and during stress
38. Does oxidative damage to DNA increase with age?
39. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
40. On the virtual existence of superoxide anions in mitochondria: Thoughts regarding its role in pathophysiology
41. DNA repair and aging in mouse liver: 8-OxoDG glycosylase activity increase in mitochondrial but not in nuclear extracts
42. Effects of growth hormone on hypothalamic catalase and CuZn superoxide dismutase
43. Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice
44. Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size
45. Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats
46. Structure and functions of the 20S and 26S proteasomes
47. Intracellular distribution of proteasomes
48. Protein oxidation and aging
49. Protein oxidation and proteolysis during aging and oxidative stress
50. Proteasome inactivation upon aging and on oxidation-effect of HSP 90
51. Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells
52. Protein damage and degradation by oxygen radicals. I. General aspects
53. Serum thiols as a surrogate estimate of DNA repair correlates with human life span
54. Hydrogen peroxide removal and glutathione mixed disulfide formation during metabolic inhibition in mesencephalic cultures
55. The measurement and mechanism of lipid perociation in biological sustems
56. 4-Hydroxynoneal and cell signaling
57. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-Hydroxy-2-nonenal is potential inducer of intracellular peroxide production
58. Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity
59. Inorganic peroxides
60. Does growth hormone prevent or accelerate aging?
61. Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH
62. Effect of thyroid status on lipid composition and peroxidation in the mouse liver
63. Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: A possible mechanism of injury to heart and skeletal muscle in hyperthyroidism
64. Accelerated aging of giant transgenic mice is associated with elevated free radical processes
65. Free radical defenses in the liver and kidney of human growth hormone transgenic mice: Possible mechanisms of early mortality
66. On size and survival: Progress and pitfalls in the allometry of life span
67. Comparative longevity of pet dogs and humans: Implications for gerontology research
68. How body height and weight affect our performance, longevity, and survival
69. Height, health and growth hormone
70. Pituitary lineage determination by the prophet of pit-1 homeodomain factor defective in Ames dwarfism
71. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
72. The 'little people' of the Island of Krk-revisited. Etiology of hypopituitarism revealed
73. Decrease in cellular replicative potential in giant mice transfected with the bovine growth hormone gene correlates to shortened life span
74. Increased glial fibrillary acidic protein (GFAP) levels in the brains of transgenic mice expressing the bovine growth hormone (bGH) gene
75. Inhibitory avoidance and appetitive learning in aged normal mice: Comparison with transgenic mice having elevated plasma growth hormone levels
76. Fertility of transgenic female mice expressing bovine growth hormone or human growth hormone variant genes
77. A mass budget for transgenic 'supermice' engineered with extra growth hormone genes: Evidence for energetic limitation
78. Effects of human growth hormone in men over 60 years old
79. Growth hormone therapy in adults with growth hormone deficiency
80. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
81. Effects of growth hormone and insulin like growth factor-1 on hepatocyte antioxidative enzymes
82. Regulation of longevity and stress resistance by Sch 9 in yeast
83. Caenorhabiditis elegans mutant that lives twice as long as wild type
84. Aging in Caenorhabditis elegans: Update 1988
85. A mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
86. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
87. shc adaptor protein controls oxidative stress and life span in mammals