Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice

Journal of Anatomy

Volumn 212, Issue 3, 2008, Pages 275-285

  Suzuki, Hironobu ^a   Amizuka, Norio ^b   Oda, Kimimitsu ^a,b   Noda, Masaki ^c   Ohshima, Hayato ^a   Maeda, Takeyasu ^a,b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Bone; Klotho; Mineralization

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; GLUTARALDEHYDE; KLOTHO PROTEIN; MAGNESIUM; PARAFORMALDEHYDE; PHOSPHORUS; PROTEIN DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MATRIX; BONE MINERALIZATION; CARTILAGE CELL; CELL ORGANELLE; CELL POPULATION; CELL SHAPE; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRON PROBE MICROANALYSIS; FEMUR; GENE DELETION; GROWTH PLATE; HISTOCHEMISTRY; MALE; METAPHYSIS; MICROSCOPY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; TIBIA; TISSUE SECTION; TRABECULAR BONE; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ANIMALS; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIFICATION, PHYSIOLOGIC; CALCIUM; ELECTRON PROBE MICROANALYSIS; FEMUR; GLUCURONIDASE; MAGNESIUM; MALE; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, ANIMAL; OSTEOBLASTS; PHOSPHORUS; TIBIA;

ANIMALIA; MUS;

EID: 40149093873     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2008.00859.x     Document Type: Article

References (46)

1. Abdallah BM, Haack-Sorensen M, Fink T, Kassem M (2006) Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females. Bone 39, 181-188.
2. Akune T, Ogata N, Hoshi K, Kubota N, Terauchi Y, Tobe K, et al. (2002) Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol 159, 147-156.
3. Amizuka N, Yamada M, Watanabe J, Hoshi K, Fukushi M, Oda K, et al. (1998) Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow. Micro Res Tech 41, 313-322.
4. Amizuka N, Davidson D, Liu H, Valverde-Franco G, Chai S, Maeda T, et al. (2004) Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Bone 34, 13-25.
5. Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, et al. (2003) Klotho allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72, 1154-1161.
6. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, et al. (2005) Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood 106, 372-375.
7. Baum M, Schiavi S, Dwarakanath V, Quigley R (2005) Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules. Kidney Int 68, 1148-1153.
8. Berndt TJ, Schiavi S, Kumar R (2005) 'Phosphatonins' and the regulation of phosphorus homeostasis: Am J Physiol Renal Physiol 289, F1170-1182.
9. Frost HM (1964) Dynamics of bone remodeling. In Bone biodynamics (ed. Frost HM), pp. 315-333 Boston: Little, Brown.
10. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N, et al. (1999) VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5, 623-628.
11. Horner A, Kemp P, Summers C, Bord S, Bishop NJ, Kelsall AW, et al. (1998) Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone. Bone 23, 95-102.
12. Ichikawa S, Imel EA, Kreiter ML, Yu X, Mackenzie DS, Sorenson AH, et al. (2007) A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest 117, 2684-2691.
13. Ikeda T, Nomura S, Yamaguchi A, Suda T, Yoshiki S (1992) In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections. J Histochem Cytochem 40, 1079-1088.
14. Imamura A, Okumura K, Ogawa Y, Murakami R, Torigoe M, Numaguchi Y, et al. (2006) Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta 371, 66-70.
15. Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, et al. (2007) Alpha-Klotho as a regulator of calcium homeostasis. Science 316, 1615-1618.
16. Kawaguchi H, Manabe N, Miyaura C, Chikuda H, Nakamura K, Kuro-o M (1999) Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J Clin Invest 104, 229-237.
17. Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector TD, et al. (2002) Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 17, 1744-1751.
18. Kuro-o M, Matsumura H, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling aging. Nature 390, 45-51.
19. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281, 6120-6123.
20. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833.
21. Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y (1998) Identification of human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 242, 626-630.
22. Metzker A, Eisenstein B, Oren J, Samuel R (1988) Tumoral calcinosis revisited - common and uncommon features. Report of ten cases and review. Eur J Pediatr 147, 128-132.
23. Mori K, Yahata K, Mukoyama M, Suganami T, Makino H, Nagae T, et al. (2000) Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem Biophys Res Commun 278, 665-670.
24. Mullin BH, Wilson SG, Islam FM, Calautti M, Dick IM, Devine A, et al. (2005) Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. Calcif Tissue Int 77, 145-151.
25. Nishino I, Amizuka N, Ozawa H (2001) Histochemical examination on osteoblastic activity in op/op mice with or without the injection of recombinant M-CSF. J Bone Miner Metab 19, 267-276.
26. Oda K, Amaya Y, Fukushi-Irie M, Kinameri Y, Ohsuye K, Kubota I, et al. (1999) A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: An application for human tissue-nonspecific alkaline phosphatase. J Biochem (Tokyo) 126, 694-699.
27. Ogata N, Chikazu D, Kubota N, Terauchi Y, Tobe K, Azuma Y, et al. (2000) Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest 105, 935-943.
28. Ogata N, Matsumura Y, Shiraki M, Kawano K, Koshizuka Y, Hosoi T, et al. (2002) Association of Klotho gene polymorphism with bone density and spondylosis of lumber spine in postmenopausal women. Bone 31, 37-42.
29. Quarles LD (2003) FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. Am J Physiol Endocrinol Metab 285, E1-E9 Review.
30. Sakagami N, Amizuka N, Li M, Takeuchi K, Hoshino M, Nakamura M, et al. (2005) A reduced osteoblastic popularity and the defective mineralization in osteopetrotic (op/op) mice. Micron 36, 688-695.
31. Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, et al. (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113, 561-568.
32. Shiraki-Iida T, Aizawa H, Matsumura Y, Sekine S, Iida A, Anazawa H, et al. (1998) Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett 424, 6-10.
33. Sugimoto T, Nishiyama K, Kuribayashi F, Chihara K (1997) Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. J Bone Miner Res 12, 1272-1279.
34. Suzuki H, Amizuka N, Oda K, Li M, Yoshie H, Ohshima H, et al. (2005) Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. Arch Histol Cytol 68, 371-381.
35. The ADHR Consortium (2000) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26, 345-348.
36. Thorp BH, Anderson I, Jakowlew SB (1992) Transforming growth factor-beta 1, -beta 2 and -beta 3 in cartilage and bone cells during endochondral ossification in the chick. Development 114, 907-911.
37. Ueda Y, Inaba M, Takada K, Fukui J, Sakaguchi Y, Tsuda M, et al. (2007) Induction of senile osteoporosis in normal mice by intra-bone marrow-bone marrow transplantation from osteoporosis-prone mice. Stem Cells 25, 1356-1363.
38. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770-774.
39. Utsugi T, Ohno T, Ohyama Y, Uchiyama T, Saito Y, Matsumura Y, et al. (2000) Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49, 1118-1123.
40. Xiao NM, Zhang YM, Zheng Q, Gu J (2004) Klotho is a serum factor related to human aging. Chin Med J 117, 742-747.
41. Yamada Y, Ando F, Niino N, Shimokata H (2005) Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med 83, 50-57.
42. Yamashita T, Nifuji A, Furuya K, Nabeshima Y, Noda M (1998) Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging. J Endocrinol 159, 1-8.
43. Yamashita T, Nabeshima Y, Noda M (2000a) High-resolution micro-computed tomography analyses of the abnormal trabecular bone structures in klotho gene mutant mice. J Endocrinol 164, 239-245.
44. Yamashita T, Yoshitake H, Tsuji K, Kawaguchi N, Nabeshima Y, Noda M (2000b) Retardation in bone resorption after bone marrow ablation in klotho mutant mice. Endocrinology 141, 438-445.
45. Yamashita T, Sekiya I, Kawaguchi N, Kashimada K, Nifuji A, Nabeshima YI, et al. (2001) Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy. J Endocrinol 168, 347-351.
46. Yoshiko Y, Wang H, Minamizaki T, Ijuin C, Yamamoto R, Suemune S, et al. (2007) Mineralized tissue cells are a principal source of FGF23. Bone 40, 1565-1573.