Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): Does APP function as a cholesterol sensor?

Biochemistry

Volumn 47, Issue 36, 2008, Pages 9428-9446

  Beel, Andrew J ^a   Mobley, Charles K ^a   Hak, Jun Kim ^a,d   Tian, Fang ^b   Hadziselimovic, Arina ^a   Jap, Bing ^c   Prestegard, James H ^b   Sanders, Charles R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d Korea Polar Research Institute (KOPRI)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINES; CHOLESTEROL; ENZYME ACTIVITY; FLOW INTERACTIONS; GLYCOPROTEINS; MINE FLOODING; NUCLEAR MAGNETIC RESONANCE; PORT TERMINALS; PROTEINS; SENSORS;

SECRETASE; TRANS-MEMBRANE DOMAINS;

CELL MEMBRANES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; C TERMINAL TRANSMEMBRANE DOMAIN OF AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; LIPID TRANSPORT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CHOLESTEROL; DIMERIZATION; HUMANS; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EID: 51549106517     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800993c     Document Type: Article

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