Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

Experimental Neurology

Volumn 185, Issue 2, 2004, Pages 208-219

  King, Gwendalyn D ^a   Turner, R Scott ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Adaptor proteins; Alzheimer's disease; Amyloid precursor protein; A ; Fe65; JIP; Mint; PTB domain; X11; Secretase; Secretase

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN X11; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CYCLOSPORIN; FUSICOCCIN; GAMMA SECRETASE; PHOSPHOTYROSINE; PROTEIN FE65; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE; TACROLIMUS; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CLINICAL TRIAL; CRYSTAL STRUCTURE; DNA POLYMORPHISM; ENZYME INHIBITION; HUMAN; MENINGOENCEPHALITIS; MOLECULAR CLONING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; RISK FACTOR; SEQUENCE HOMOLOGY; SIDE EFFECT; TWO HYBRID SYSTEM;

EID: 0345743462     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2003.10.011     Document Type: Review

References (154)

1. Aarts M., Liu Y., Liu L., Besshoh S., Arundine M., Gurd J.W., Wang Y.T., Salter M.W., Tymianski M. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science. 298:2002;846-850.
2. Ando K., Iijima K., Elliott J.I., Kirino Y., Suzuki T. Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J. Biol. Chem. 276:2001;40353-40361.
3. Araki Y., Tomita S., Yamaguchi H., Miyagi N., Sumioka A., Kirino Y., Suzuki T. Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J. Biol. Chem. 2003;. (in press).
4. Bayer T.A., Cappai R., Masters C.L., Beyreuther K., Multhaup G. It all sticks together - The APP-related family of proteins and Alzheimer's disease. Mol. Psychiatry. 4:1999;524-528.
5. Bennett B.D., Babu-Khan S., Loeloff R., Louis J.C., Curran E., Citron M., Vassar R. Expression analysis of Bace2 in brain and peripheral tissues. J. Biol. Chem. 275:2000;20647-20651.
6. Biederer T., Sudhof T.C. Mints as adaptors - Direct binding to neurexins and recruitment of Munc18. J. Biol. Chem. 275:2000;39803-39806.
7. Biederer T., Cao X.W., Sudhof T.C., Liu X.R. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of mint isoforms. J. Neurosci. 22:2002;7340-7351.
8. Blacker D., Bertram L., Saunders A.J., Moscarillo T.J., Albert M.S., Weiner H., Perry R.T., Collins J.S., Harrell L.E., Go R., Mahoney A., Beaty T., Falin M.D., Avramopoulos D., Chase G.A., Folstein M.F., McInnis M.G., Bassett S.S., Doheny K.J., Pugh E.W., Tanzi R.E. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Human Mol. Genet. 12:2003;23-32.
9. Borg J.P., Margolis B. Function of PTB domains. Curr. Top. Microbiol. 228:1998;1230-1237.
10. Borg J.P., Ooi J., Levy E., Margolis B. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16:1996;6229-6241.
11. Borg J.P., Straight S.W., Kaech S.M., de Taddeo-Borg M., Kroon D.E., Karnak D., Turner R.S., Kim S.K., Margolis B. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J. Biol. Chem. 273:1998;31633-31636.
12. Borg J.P., Yang Y., De Taddeo-Borg M., Margolis B., Turner R.S. The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J. Biol. Chem. 273:1998;14761-14766.
13. Borg J.P., Lopez-Figueroa M.O., de Taddeo-Borg M., Kroon D.E., Turner R.S., Watson S.J., Margolis B. Molecular analysis of the X11-mLin-2/CASK complex in brain. J. Neurosci. 19:1999;1307-1316.
14. Breen K.C., Bruce M., Anderton B.H. Beta-Amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion. J. Neurosci. Res. 28:1991;90-100.
15. Bressler S.L., Gray M.D., Sopher B.L., Hu Q.B., Hearn M.G., Pham D.G., Dinulos M.B., Fukuchi K.I., Sisodia S.S., Miller M.A., Disteche C.M., Martin G.M. cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Human Mol. Genet. 5:1996;1589-1598.
16. Brouillet E., Trembleau A., Galanaud D., Volovitch M., Bouillot C., Valenza C., Prochiantz A., Allinquant B. The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized for signal transduction. J. Neurosci. 19:1999;1717-1727.
17. Butz S., Okamoto M., Sudhof T.C. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell. 94:1998;773-782.
18. Buxbaum J.D., Liu K.N., Luo Y.X., Slack J.L., Stocking K.L., Peschon J.J., Johnson R.S., Castner B.J., Cerretti D.P., Black R.A. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:1998;27765-27767.
19. Cao X., Sudhof T.C. A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 293:2001;1436.
20. Cescato R., Dumermuth E., Spiess M., Paganetti P.A. Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis. J. Neurochem. 74:2000;1131-1139.
21. Chang Y., Tesco G., Jeong W.J., Lindsley L., Eckman E.A., Eckman C.G., Tanzi R.E., Guenette S.Y. Generation of beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by Fe65L1. J. Biol. Chem. 2003;. (in press).
22. Chen M., Yankner B.A. An antibody to beta-Amyloid and the Amyloid Precursor Protein inhibits cell-substratum adhesion in many mammalian-cell types. Neurosci. Lett. 125:1991;223-226.
23. Chen W.J., Goldstein J.L., Brown M.S. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265:1990;3116-3123.
24. Chen Y.Z., McPhie D.L., Hirschberg J., Neve R.L. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J. Biol. Chem. 275:2000;8929-8935.
25. Chen Y., Liu W., McPhie D.L., Hassinger L., Neve R. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J. Cell Biol. 163:2003;27-33.
26. Choi J., Chen J., Schreiber S.L., Clardy J. Structure of the FKBP12-rapamycin complex interacting with binding domain of human FRAP. Science. 273:1996;239.
27. Chow N., Korenberg J.R., Chen X.-N., Neve R.L. APP-BP1, a novel protein that binds to the carboxy-terminal region of the amyloid precursor protein. J. Biol. Chem. 271:1996;11339-11346.
28. Citron M. Emerging Alzheimer's disease therapies: inhibition of beta-secretase. Neurobiol. Aging. 23:2002;1017-1022.
29. Collawn J.F., Stangel M., Kuhn L.A., Esekogwu V., Jing S.Q., Trowbridge I.S., Tainer J.A. Tranferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell. 63:1990;1061-1072.
30. Cousin E., Hannequin D., Ricard S., Mace S., Genin E., Chansas C., Brice A., Dubois B., Frebourg T., Mercken L., Benavides J., Pradier L., Campion D., Deleuze J.-F. A risk for early-onset Alzheimer's disease associated with the APBB1 gene (Fe65) intron 13 polymorphism. Neurosci. Lett. 342:2003;5-8.
31. Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Biochem. J. 330:1998;513-519.
32. Enyedy I.J., Ling Y., Nacro K., Tomita Y., Wu X., Cao Y., Guo R., Li B., Zhu X., Huang Y., Long Y.Q., Roller P.P., Yang D., Wang S. Discovery of small-molecule inhibitors of Bcl-2 through structure based computer screening. J. Med. Chem. 44:2001;4313-4324.
33. Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., Sudol M. The WW domain of neural protein Fe65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J. Biol. Chem. 272:1997;32869-32877.
34. Esler W.P., Kimberly W.T., Ostaszewski B.L., Ye W.J., Diehl T.S., Selkoe D.J., Wolfe M.S. Activity-dependent isolation of the presenilin-gamma-secretase complex reveals nicastrin and a gamma substrate. Proceedings of the National Academy of Sciences of the United States of America. 99:2002;2720-2725.
35. Essalmani R., Macq A.F., Mercken L., Octave J.N. Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor. Biochem. Biophys. Res. Commun. 218:1996;89-96.
36. Fiore F., Zambrano N., Minopoli G., Donini V., Duilio A., Russo T. The regions of the Fe65 protein homologous to the phosphotyrosine interaction phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270:1995;30853-30856.
37. Gadek T.R., Burdick D.J., McDowell R.S., Stanley M.S., Marsters J.C., Paris K.J., Oare D.A., Reynolds M.E., Ladner C., Zioncheck K.A., Lee W.P., Gribling P., Dennis M.S., Skelton N.J., Tumas D.B., Clark K.R., Keating S.M., Beresini M.H., Tilley J.W., Presta L.G., Bodary S.C. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science. 295:2002;1086-1089.
38. Ghiso J., Rostagno A., Gardella J.E., Liem L., Gorevic P.D., Frangione B. A 109-Amino-Acid C-Terminal fragment of Alzheimer's disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell-adhesion. Biochem. J. 288:1992;1053-1059.
39. Griffith J.P., Kim J.L., Kim E.E., Sintchak M.D., Thomason J.A., Fitzgibbon M.J., Fleming M.A., Caron P.R., Hsiao K., Navia M.A. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell. 82:1995;507-522.
40. Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E. Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 93:1996;10832-10837.
41. Guenette S.Y., Chen J., Ferland A., Haass C., Capell A., Tanzi R.E. hFE65L influences amyloid precursor protein maturation and secretion. J. Neurochem. 73:1999;985-993.
42. Guenette S.Y., Bertram L., Crystal A., Bakondi B., Hyman B.T., Rebeck G.W., Tanzi R.E., Blacker D. Evidence against association of the Fe65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci. Lett. 296:2000;17-20.
43. Guenette S.Y., Chang Y., Hyman B.T., Tanzi R.E., Rebeck G.W. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J. Neurochem. 82:2002;755-762.
44. Haniu M., Denis P., Young Y., Mendiaz E.A., Fuller J., Hui J.O., Bennett B.D., Kahn S., Ross S., Burgess T., Katta V., Rogers G., Vassar R., Citron M. Characterization of Alzheimer's beta-secretase protein BACE - A pepsin family member with unusual properties. J. Biol. Chem. 275:2000;21099-21106.
45. Hardy J. An anatomical cascade hypothesis for Alzheimers disease. Trends Neurosci. 15:1992;200-201.
46. Hase M., Yagi Y., Taru H., Tomita S., Sumioka A., Hori K., Miyamoto K., Sasamura T., Nakamura M., Matsuno K., Suzuki T. Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J. Neurochem. 81:2002;1223-1232.
47. Heber S., Herms J., Gajic V., Hainfellner J., Aguzzi A., Rulicke T., Kretzschmar H., von Koch C., Sisodia S., Tremml P., Lipp H.P., Wolfer D.P., Muller U. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20:2000;7951-7963.
48. Hedera P., Turner R.S. Inherited dementias. Neurol. Clin. 20:2002;770-808.
49. Helbecque N., Abderrhamani A., Meylan L., Riederer B., Mooser V., Miklossy J., Deplanque J., Boutin P., Nicod P., Haefliger J.-A., Cottel D., Amouyel P., Froguel P., Waeber G. Islet-brain 1/C-jun N-terminal kinase interacting protein-1 (IB1/JIP1) promoter variant is associated with Alzheimer's disease. Mol. Psychiatry. 8:2003;413-422.
50. Hill K., Li Y., Bennett M., McKay M., Zhu X., Shern J., Torre E., Lah J.J., Levey A.I., Kahn R.A. Munc 18 interacting (MINT) proteins: Arf-dependent coat proteins that regulate traffic of the Alzheimer's precursor protein (beta-APP). J. Biol. Chem. 2003.
51. Ho C.S., Marinescu V., Steinhilb M.L., Gaut J.R., Turner R.S., Stuenkel E.L. Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. J. Biol. Chem. 278:2003;36032-36040.
52. Ho A., Morishita W., Hammer R.E., Malenka R.C., Sudhof T.C. A role for Mints in transmitter release: mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc. Natl. Acad. Sci. U. S. A. 100:2003;1409-1414.
53. Homayouni R., Rice D.S., Sheldon M., Curran T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J. Neurosci. 19:1999;7507-7515.
54. Hoskins R., Hajnal A.F., Harp S.A., Kim S.K. The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development. 122:1996;97-111.
55. Howell B.W., Lanier L.M., Frank R., Gertler F.B., Cooper J.A. The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol. Cell. Biol. 19:1999;5179-5188.
56. Hu Q., Kukull W.A., Bressler S.L., Gray M.D., Cam J.A., Larson E.B., Martin G.M., Deeb S.S. The human Fe65 gene: genomic structure and intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. Hum. Genet. 103:1998;295-303.
57. Hu Q.B., Cool B.H., Wang B.P., Hearn M.G., Martin G.M. A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type. Human Mol. Genet. 11:2002;465-475.
58. Ide N., Hata Y., Hirao K., Irie M., Deguchi M., Yao I., Satoh A., Wada R., Takahashi K., Nakanishi H., Takai Y. Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin. Biochem. Biophys. Res. Commun. 244:1998;258-262.
59. Ikezu T., Trapp B.D., Song K.S., Schlegel A., Lisante M.P., Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase mediated processing of amyloid precursor protein. J. Biol. Chem. 273:1998;10485-10495.
60. Inomata H., Nakamura Y., Hayakawa A., Takata H., Suzuki T., Miyazawa K., Kitamura N. A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J. Biol. Chem. 278:2003;22946-22955.
61. Jin L.W., Ninomiya H., Roch J.M., Schubert D., Masliah E., Otero D.A.C., Saitoh T. Peptides containing the RERMS sequence of amyloid beta/A4 protein-precursor bind cell-surface and promote neurite extension. J. Neurosci. 14:1994;5461-5470.
62. Jo K., Derin R., Li M., Bredt D.S. Characterization of MALS/Velis-1, -1, and -3: a family of mammalian Lin-7 homologs enriched at brain synapses in association with the postsynaptic density 95/NMDA receptor postsynaptic complex. J. Neurosci. 19:1999;4189-4199.
63. Joachim C.L., Morris J.H., Selkoe D.J. Diffuse senile plaques occur commonly in the cerebellum in Alzheimers disease. Am. J. Pathol. 135:1989;309-319.
64. Kaech S.M., Whitfield C.W., Kim S.K. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell. 94:1998;761-771.
65. Kamal A., Stokin G.B., Yang Z.H., Xia C.H., Goldstein L.S.B. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28:2000;449-459.
66. Kamal A., Almenar-Queralt A., LeBlanc J.F., Roberts E.A., Goldstein L.S.B. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 414:2001;643-648.
67. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Mullerhill B. The precursor of Alzheimers-disease amyloid-A4 protein resembles a cell-surface receptor. Nature. 325:1987;733-736.
68. Kesavapany S., Banner S.J., Lau K.F., Shaw C.E., Miller C.C.J., Cooper J.D., McLoughlin D.M. Expression of the Fe65 adapter protein in adult and developing mouse brain. Neuroscience. 115:2002;951-960.
69. Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a Notch-like manner. J. Biol. Chem. 276:2001;40288-40292.
70. King G.D., Cherian K., Turner R.S. X11alpha impairs gamma but not beta-secretase cleavage of amyloid precursor protein. J. Neurochem. 2004;. (in press).
71. King G.D., Perez R.G., Steinhilb M.L., Gaut J.R., Turner R.S. X11alpha modulates secretory and endocytic trafficking and metabolism of Amyloid Precursor Protein: mutational analysis of the YENPTY sequence. Neuroscience. 120:2003;143-154.
72. Kinoshita A., Whelan C.M., Smith C.J., Mikhailenko I., Rebeck G.W., Strickland D.K., Hyman B.T. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. J. Neurosci. 21:2001;8354-8361.
73. Koo E.H., Squazzo S.L. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269:1994;17386- 17389.
74. Lai A., Gibson A., Hopkins C.R., Trowbridge I.S. Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in Madin-Darby canine kidney cells. J. Biol. Chem. 273:1998;3732-3739.
75. Lambert J.C., Mann D., Goumidi L., Harris J., Pasquier F., Frigard B., Cottel D., Lendon C., Iwatsubo T., Amouyel P., Chartier-Harlin M.C. A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer's disease but not with A beta loading in brains. Neurosci. Lett. 293:2000;29-32.
76. Lau K.F., McLoughlin D.M., Standen C., Miller C.C.J. X11alpha and X11beta interact with presenilin-1 via their PDZ domains. Mol. Cell. Neurosci. 16:2000;557-565.
77. Lau K.F., McLoughlin D.M., Standen C.L., Irving N.G., Miller C.C.J. Fe65 and X11 beta co-localize with and compete for binding to the amyloid precursor protein. NeuroReport. 11:2000;3607-3610.
78. Leblanc A.C., Gambetti P. Production of Alzheimer 4-kDa beta-amyloid peptide requires the C-terminal cytosolic domain of the amyloid precursor protein. Biochem. Biophys. Res. Commun. 204:1994;1371-1380.
79. Lee D.S., Tomita S., Kirino Y., Suzuki T. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J. Biol. Chem. 275:2000;23134-23138.
80. Lee S.-F., Shah S., Li H., Yu C., Han W., Yu G. Mammalian APH-1 interacts with Presenilin and Nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J. Biol. Chem. 277:2000;45013-45019.
81. Lee J.-H., Lau K.F., Perkinton M.S., Standen C.L., Shemilt S.J.A., Mercken L., Cooper J.D., McLoughlin D.M., Miller C.J. The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. J. Biol. Chem. 2003;. (in press).
82. Li Y.M., Lai M.T., Xu M., Huang Q., DiMuzio-Mower J., Sardana M.K., Shi X.P., Yin K.C., Shafer J.A., Gardell S.J. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6138-6143.
83. Li Y.M., Xu M., Lai M.T., Huang Q., Castro J.L., DiMuzio-Mower J., Harrison T., Lellis C., Nadin J.L., Neduvelil J.G., Register R.B., Sardana M.K., Shearman M.S., Smith A.L., Shi X.P., Yin K.C., Shafer J.A., Gardell S.J. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 405:2000;689-694.
84. Margolis B., Borg J.P., Straight S., Meyer D. The function of PTB domain proteins. Kidney Int. 56:1999;1230-1237.
85. Matsuda S., Yasukawa T., Homma Y., Ito Y., Niikura T., Hiraki T., Hirai S., Ohno S., Kita Y., Kawasumi M., Kouyama K., Yamamoto T., Kyriakis J.M., Nishimoto I. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet- brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21:2001;6597-6607.
86. Matsuda S., Matsuda Y., Dadamio L. Amyloid beta protein precursor, but not APLP2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J. Biol. Chem. 278:2003;38601-38606.
87. Mattson M.P., Cheng B., Culwell A.R., Esch F.S., Lieberburg I., Rydel R.E. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron. 10:1993;243-254.
88. Maximov A., Sudhof T.C., Bezprozvanny I. Association of neuronal calcium channels with modular adaptor proteins. J. Biol. Chem. 274:1999;24453-24456.
89. McLoughlin D.M., Miller C.C.J. The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett. 397:1996;197-200.
90. McLoughlin D.M., Irving N.G., Brownlees J., Brion J.P., Leroy K., Miller C.C.J. Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. Eur. J. Neurosci. 11:1999;1988-1994.
91. McLoughlin D.M., Standen C.L., Lau K.F., Ackerley S., Bartnikas T.P., Gitlin J.D., Miller C.C.J. The neuronal adaptor protein X11 alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity. J. Biol. Chem. 276:2001;9303-9307.
92. Menon R., Bertram L., Mullin K., Parkinson M., Bradley M.L., Becker K.D., Velicelebi G., Moscarillo T., Saunders A.J., Blacker D., Tanzi R.E. Search for novel Alzheimer's disease genes on Chromosome 9. Soc. Neurosci. Abs. 2003;134.5.
93. Minopoli G., de Candia P., Bonetti A., Faraonio R., Zambrano N., Russo T. The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation. J. Biol. Chem. 276:2001;6545-6550.
94. Mori A., Okuyama K., Horie M., Taniguchi Y., Wadatsu T., Nishino N., Shimada Y., Miyazawa N., Takeda S., Niimi M., Kyushiki H., Kondo M., Mitsumoto Y. Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Neurosci. Res. 43:2002;251-257.
95. Mueller H.T., Borg J.P., Margolis B., Turner R.S. Modulation of amyloid precursor protein metabolism by X11 alpha/Mint-1 - A deletion analysis of protein-protein interaction domains. J. Biol. Chem. 275:2000;39302-39306.
96. Nakajima Y., Okamoto M., Nishimura H., Obata K., Kitano H., Sugita M., Matsuyama T. Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain. Mol. Brain Res. 92:2001;27-42.
97. Nishimoto I., Okamoto T., Matsuura Y., Takahashi S., Murayama Y., Ogata E. Alzheimer amyloid protein-precursor complexes with brain GTP-binding protein-G(o). Nature. 362:1993;75-79.
98. Nishiyama K., Trapp B.D., Ikezu T., Ransohoff R.M., Tomita T., Iwatsubo T., Kanazawa I., Hsiao K., Lisanti M.P., Okamoto T. Caveolin-3 upregulation activates beta-secretase mediated cleavage of amyloid precursor protein in Alzheimer's disease. J. Neurosci. 19:1999;6538-6548.
99. Noviello C., Vito P., Lopez P., Abdallah M., D'Adamio L. Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimers amyloid beta precursor protein. J. Biol. Chem. 278:2003;31843-31847.
100. Okamoto M., Sudhof T.C. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. J. Biol. Chem. 272:1997;31459-31464.
101. Okamoto M., Sudhof T.C. Mint 3: a ubiquitous mint isoform that does not bind to munc18- 1 or -2. Eur. J. Cell Biol. 77:1998;161-165.
102. Okamoto T., Takeda S., Murayama Y., Ogata E., Nishimoto I. Ligand-dependent G-protein coupling function of amyloid transmembrane precursor. J. Biol. Chem. 270:1995;4205-4208.
103. Okamoto T., Takeda S., Giambarella U., Murayama Y., Matsui T., Katada T., Matsuura Y., Nishimoto I. Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. EMBO J. 15:1996;3769-3777.
104. Okamoto M., Matsuyama T., Sugita M. Ultrastructural localization of mint1 at synapses in mouse hippocampus. Eur. J. Neurosci. 12:2000;3067-3072.
105. Okamoto M., Nakajima Y., Matsuyama T., Sugita M. Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane. Neuroscience. 104:2001;653-665.
106. Perez R.G., Soriano S., Hayes J.D., Ostaszewski B., Xia W.M., Selkoe D.J., Chen X.H., Stokin G.B., Koo E.H. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including A beta 42. J. Biol. Chem. 274:1999;18851-18856.
107. Prince J.A., Feuk L., Sawyer S.L., Gottfries J., Ricksten A., Nagga K., Bogdanovic N., Blennow K., Bookes A.J. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur. J. Hum. Genet. 9:2001;437-444.
108. Rongo C., Whitfield C.W., Rodal A., Kim S.K., Kaplan J.M. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell. 94:1998;751-759.
109. Russo C., Salis S., Dolcini V., Venezia V., Song X.H., Teller J.K., Schettini G. Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain. Neurobiol. Dis. 8:2001;173-180.
110. Russo C., Dolcini V., Salis S., Venezia V., Zambrano N., Russo T., Schettini G. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/ Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. J. Biol. Chem. 277:2002;35282-35288.
111. Sabo S.L., Lanier L.M., Ikin A.F., Khorkova O., Sahasrabudhe S., Greengard P., Buxbaum J.D. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274:1999;7952-7957.
112. Sabo S.L., Ikin A.F., Buxbaum J.D., Greengard P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J. Cell Biol. 153:2001;1403-1414.
113. Sabo S., Ikin A.F., Buxbaum J.D., Greengard P. The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. J. Neurosci. 23:2003;5407-5415.
114. Salinero O., Moreno-Flores M.T., Wandosell F. Increasing neurite outgrowth capacity of beta-amyloid precursor protein proteoglycan in Alzheimer's disease. J. Neurosci. Res. 60:2000;87-97.
115. Sastre M., Turner R.S., Levy E. X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J. Biol. Chem. 273:1998;22351-22357.
116. Scheinfeld M.H., Roncarati R., Vito P., Lopez P.A., Abdallah M., D'Adamio L. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J. Biol. Chem. 277:2002;3767-3775.
117. Schlessinger J., Lemmon M.A. SH2 and PTB domains in tyrosine kinase signaling. Science's STKE. 2003;1-11.
118. Schubert D., Behl C. The expression of Amyloid-Beta Protein-Precursor protects nerve cells from beta-Amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Res. 629:1993;275-282.
119. Schubert D., Jin L.W., Saitoh T., Cole G. The regulation of amyloid-beta-protein precursor secretion and its modulatory role in cell adhesion. Neuron. 3:1989;689-694.
120. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766.
121. Selkoe D.J., Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 26:2003;565-597.
122. Setou M., Nakagawa T., Seog D.H., Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 288:2000;1796-1802.
123. Shioi J., Anderson J.P., Ripellino J.A., Robakis N.K. Chondroitin sulfate proteoglycan form of the Alzheimers beta-amyloid precursor. J. Biol. Chem. 267:1992;13819-13822.
124. Shioi J., Refolo L.M., Efthimiopoulos S., Robakis N.K. Chondroitin sulfate proteoglycan form of cellular and cell- surface Alzheimer amyloid precursor. Neurosci. Lett. 154:1993;121-124.
125. Simske J.S., Kaech S.M., Harp S.A., Kim S.K. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell. 85:1996;195-204.
126. Steiner H., Winkler E., Edbauer D., Prokop S., Basset G., Yamasaki A., Kostka M., Haass C. PEN-2 is an integral component of the gamma-secretase complex required for the coordinated expression of presenilin and nicastrin. J. Biol. Chem. 277:2002;39062-39065.
127. Sumioka A., Imoto S., Martins R.N., Kirino Y., Suzuki T. XB51 isoforms mediate Alzheimer's beta-amyloid production by X11L dependent and independent mechanisms. Biochem. J. 374:2003;261-268.
128. Suzuki T., Oishi M., Marshak D.R., Czernik A.J., Nairn A.C., Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J. 13:1994;1114-1122.
129. Tanahashi H., Tabira T. Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's amyloid precursor protein. NeuroReport. 10:1999;2575-2578.
130. Tanahashi H., Tabira T. Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. Neurosci. Lett. 261:1999;143-146.
131. Tanahashi H., Tabira T. X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Biochem. Biophys. Res. Commun. 255:1999;663-667.
132. Tanahashi H., Tabira T. Characterization of an amyloid precursor protein (APP) binding protein, Fe65L2, and its novel isoforms lacking phosphotyrosine interaction domains. Biochem. J. 367:2002;687-695.
133. Tarr P.E., Roncarati R., Pelicci G., Pelicci P.G., D'Adamio L. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277:2002;16798-16804.
134. Taru H., Iijima K., Hase M., Kirino Y., Yagi Y., Suzuki T. Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J. Biol. Chem. 277:2002;20070-20078.
135. Taru H., Kirino Y., Suzuki T. Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J. Biol. Chem. 277:2002;27567-27574.
136. Thinakaran G., Slunt H.H., Sisodia S.S. Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homolog, APLP2. J. Biol. Chem. 270:1995;16522-16525.
137. Tomita S., Kirino Y., Suzuki T. A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site. J. Biol. Chem. 273:1998;19304-19310.
138. Tomita S., Ozaki T., Taru H., Oguchi S., Takeda S., Yagi Y., Sakiyama S., Kirino Y., Suzuki T. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J. Biol. Chem. 274:1999;2243-2254.
139. Trommsdorff R., Borg J.P., Margolis B., Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273:1998;33556-33560.
140. Turner R.S. Neurological aspects of Alzheimer's disease. Lichtenberg P.A., Murman D.L., Mellow A.M. Handbook of Dementia. Psychological, Neurological, and Psychiatric Perspectives. 2003;1-24 Wiley, Hoboken, NJ.
141. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller L., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., Citron M. beta-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:1999;735-741.
142. Walhout A.J.M., Sordella R., Lu X.W., Hartley J.L., Temple G.F., Brasch M.A., Thierry-Mieg N., Vidal M. Protein interaction mapping in C. elegans using proteins involved in vulval development. Science. 287:2000;116-122.
143. Watanabe T., Sukegawa J., Sukegawa I., Tomita S., Iijima K., Oguchi S., Suzuki T., Nairn A.C., Greengard P. A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein. J. Neurochem. 72:1999;549-556.
144. Whitfield C.W., Benard C., Barnes T., Hekimi S., Kim S.K. Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol. Biol. Cell. 10:1999;2087-2100.
145. Wolfe M.S., Xia W.M., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398:1999;513-517.
146. Wurtele M., Jelich-Ottomann C., Wittinghofer A., Oecking C. Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J. 22:2003;987-994.
147. Yamazaki T., Koo E.H., Selkoe D.J. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. J. Neurosci. 17:1997;1004-1010.
148. Yan R., Munzner J.B., Shuck M.E., Bienkowski M.J. BACE2 functions as an alternative alpha secretase in cells. J. Biol. Chem. 276:2001;34019-34027.
149. Yan K.S., Kuti M., Zhou M.M. PTB or not PTB - That is the question. FEBS Lett. 513:2002;67-70.
150. Zambrano N., Bruni P., Minopoli G., Mosca R., Molino D., Russo C., Schettini G., Sudol M., Russo T. The beta-amyloid precursor protein APP is tyrosine- phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J. Biol. Chem. 276:2001;19787-19792.
151. Zambrano N., Buxbaum J.D., Minopoli G., Fiore F., DeCandia P., DeRenzis S., Faraonio R., Sabo S., Cheetham J., Sudol M., Russon T. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins. J. Biol. Chem. 272:1997;6399-6405.
152. Zambrano N., Minopoli G., de Candia P., Russo T. The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. J. Biol. Chem. 273:1998;20128-20133.
153. Zhang Z.T., Lee C.H., Mandiyan V., Borg J.P., Margolis B., Schlessinger J., Kuriyan J. Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J. 16:1997;6141-6150.
154. Zheng P.Z., Eastman J., Vande Pol S., Pimplikar S.W. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. U. S. A. 95:1998;14745-14750.