Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

Nature Cell Biology

Volumn 4, Issue 10, 2002, Pages 743-749

  Haendeler, Judith ^a   Hoffmann, Jörg ^a   Tischler, Verena ^a   Berk, Bradford C ^b   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; NITRIC OXIDE; NITROSO DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOREDOXIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COMPOSITION; CELL GROWTH; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSFECTION; GROWTH REGULATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; APOPTOSIS; CELLS, CULTURED; CYSTEINE; DOWN-REGULATION; ENDOTHELIUM; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HUMANS; MUTATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN COMPOUNDS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SULFUR; THIOREDOXIN; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0036798856     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb851     Document Type: Article

References (43)

1. Holmgren, A. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 264, 13963-13966 (1989).
2. Nordberg, J. & Arner, E. S. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 31, 1287-1312 (2001).
3. Matsui, M. et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev. Biol. 178, 179-185 (1996).
4. Reichard, P. From RNA to DNA, why so many ribonucleotide reductases? Science 260, 1773-1777 (1993).
5. Lundstrom, J. & Holmgren, A. Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity. J. Biol. Chem. 265, 9114-9120 (1990).
6. Tanaka, T. et al. Redox regulation by thioredoxin superfamily: protection against oxidative stress and aging. Free Radic. Res. 33, 851-855 (2001).
7. Hirota, K. et al. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl Acad. Sci. USA 94, 3633-3638 (1997).
8. Matthews, J. R., Wakasugi, N., Virelizier, J. L., Yodoi, J. & Hay, R. T. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 20, 3821-3830 (1992).
9. Schenk, H., Klein, M., Erdbrugger, W., Droge, W. & Schulze-Osthoff, K. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1. Proc. Natl Acad. Sci. USA 91, 1672-1676 (1994).
10. Saitoh, M. et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17, 2596-2606 (1998).
11. Moncada, S. & Higgs, A. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329, 2002-2012 (1993).
12. Harrison, D. G. Endothelial dysfunction in atherosclerosis. Basic Res. Cardiol. 1, 87-102 (1994).
13. Tsao, P. S. & Cooke, J. P. Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction. J. Cardiovasc. Pharmacol. 32(Suppl. 3), S48-S53 (1998).
14. Murohara, T. et al. Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler. Thromb. Vasc. Biol. 19, 1156-1161 (1999).
15. Dimmeler, S. & Zeiher, A. M. Nitric oxide - an endothelial cell survival factor. Cell Death Differ. 6, 964-968 (1999).
16. Stamler, J. S. et al. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc. Natl Acad. Sci. USA 89, 444-448 (1992).
17. Liu, L. & Stamler, J. S. NO: an inhibitor of cell death. Cell Death Differ. 6, 937-942 (1999).
18. Melino, G. et al. S-nitrosylation regulates apoptosis. Nature 388, 432-433 (1997).
19. Eu, J. P., Liu, L., Zeng, M. & Stamler, J. S. An apoptotic model for nitrosative stress. Biochemistry 39, 1040-1047 (2000).
20. Hoffmann, J., Haendeler, J., Zeiher, A. M. & Dimmeler, S. TNF-α and oxLDL induce a denitrosylation of proteins in endothelial cells. J. Biol. Chem. 276, 41383-41387 (2001).
21. Stamler, J. S., Lamas, S. & Fang, F. C. Nitrosylation. the prototypic redox-based signaling mechanism. Cell 106, 675-683 (2001).
22. Mannick, J. B. et al. Fas-induced caspase denitrosylation. Science 284, 651-654 (1999).
23. sNO signals: translocation, regulation, and a consensus motif. Neuron 18, 691-696 (1997).
24. Stamler, J. S. & Hausladen, A. Oxidative modifications in nitrosative stress. Nature Struct. Biol, 5, 247-249 (1998).
25. Jaffrey, S. R., Erdjument-Bromage, H., Ferris, C. D., Tempst, P. & Snyder, S. H. Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nature Cell Biol. 3, 193-197 (2001).
26. Dalton, T. P., Shertzer, H. G. & Puga, A. Regulation of gene expression by reactive oxygen. Annu. Rev. Pharmacol. Toxicol, 39, 67-101 (1999).
27. Nakamura, H., Nakamura, K. & Yodoi, J. Redox regulation of cellular activation. Annu. Rev. Immunol, 15, 351-369 (1997).
28. Andoh, T., Chock, P. B. & Chiueh, C. C. The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells. J. Biol. Chem. 277, 9655-9660 (2002).
29. Baker, A., Payne, C. M., Briehl, M. M. & Powis, G. Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res. 57, 5162-5167 (1997).
30. Abello, P. A., Fidler, S. A. & Buchman, T. G. Thiol reducing agents modulate induced apoptosis in porcine endothelial cells. Shock 2, 79-83 (1994).
31. Dimmeler, S. & Zeiher, A. M. Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors. Regul. Pept. 90, 19-25 (2000).
32. Chandra, J., Samali, A. & Orrenius, S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29, 323-333 (2000).
33. Bayraktutan, U., Blayney, L. & Shah, A. M. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 20, 1903-1911 (2000).
34. Li, J., Billiar T. R., Talanian, R. V. & Kim, Y. M. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem. Biophys. Res. Commun. 240, 419-424 (1997).
35. Dimmeler, S., Haendeler, J., Nehls, M. & Zeiher, A. M. Suppression of apoptosis by nitric oxide via inhibition of ICE-like and CPP32-like proteases. J. Exp. Med. 185, 601-608 (1997).
36. Haendeler, J., Weiland, U., Zeiher, A. M. & Dimmeler, S. Effects of redox-related congeners on apoptosis and caspase-3 activity. Nitric Oxide 1, 282-293 (1997).
37. Tenneti, L., D'Emilia, D. M. & Lipton, S. A. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neurosci. Lett. 236, 139-142 (1997).
38. 2 sensor and NO signaling functions. Cell 102, 499-509 (2000).
39. Pawloski, J. R., Hess, D. T. & Stamler, J. S. Export by red blood cells of nitric oxide bioactivity. Nature 409, 622-626 (2001).
40. Sun, J., Xin, C., Eu, J. P., Stamler, J. S. & Meissner, G. Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO. Proc. Natl Acad. Sci, USA 98, 11158-11162 (2001).
41. Haendeler, J., Ishida, M., Hunyady, L. & Berk, B. C. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. Circ. Res. 86, 729-736 (2000).
42. Dimmeler, S., Haendeler, J., Galle, J. & Zeiher, A. M. Oxidized low density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: a mechanistic clue to the response to injury hypothesis. Circulation 95, 1760-1763 (1997).
43. Park, H. S., Huhn, S. H., Kim, M. S., Lee, S. H. & Choi E. J. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc. Natl Acad. Sci. USA 97, 14022-14024 (2000).