Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma

Cancer Research

Volumn 56, Issue 23, 1996, Pages 5522-5528

  Kimura, Hiroyuki ^a   Braun, Rod D ^a   Ong, Edgardo T ^a   Hsu, Richard ^b   Secomb, Timothy W ^b   Papahadjopoulos, Demetrios ^c   Hong, Keelung ^c   Dewhirst, Mark W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; ERYTHROCYTE; HYPOXIA; NONHUMAN; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; RAT; REOXYGENATION; TUMOR VASCULARIZATION;

ADENOCARCINOMA; ANIMALS; BACK; BLOOD FLOW VELOCITY; CELL HYPOXIA; ERYTHROCYTES; FLUORESCENT DYES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICROCIRCULATION; NEOPLASM TRANSPLANTATION; OXYGEN; PARTIAL PRESSURE; RATS; RATS, INBRED F344; REPERFUSION; SKIN WINDOW TECHNIQUE; TUMOR CELLS, CULTURED;

EID: 0030476061     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Dische, S. Hyperbaric oxygen: The Medical Research Council trials and their clinical significance. Br. J. Radiol , 51, 888-894, 1978.
2. Dische, S. Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiother. Oncol., 3: 97-115, 1985.
3. Shweiki, D., Itin, A., Soffer, D., and Kesht E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (Lond.), 559, 843-845, 1992.
4. Sutherland, R. M. Tumor hypoxia and heterogeneity: challenges and opportunities for the future. Semin. Radiation Oncology, 6: 59-70, 1996.
5. Graeber, T. G., Osmanian, C., Jacks, T , Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature (Lond), 379: 88-91, 1996.
6. Brizel, D. M., Scully, S. P., Harrelson, J. M , Layfield, L. J., Bean, J. M., Prosnitz, L. R., and Dehirst, M. W. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res , 56: 941-943, 1996
7. Schwickert, G., Walenta, S., Sundfor, K., Rofstad, E. K., and Mueller-Klieser, W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res , 55: 4757-4759, 1995
8. Vaupel, P , Kallinowski, F., and Okunieff, P. Blood flow, oxygen, nutrient supply and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.
9. Secomb, T. W., Hsu, R , Ong, E. T., Gross, J. F., and Dewhirst, M. W. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol., 34: 313-316, 1995.
10. Dewhirst, M. W., Ong, E. T., Klitzman, B., Secomb, T. W., Vinuya, R. Z., Dodge, R., Brizel, D., and Gross, J. F. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. Radiat. Res., 130: 171-182, 1992.
11. Chaplin, D J., Olive, P. L., and Durand, R. E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res., 47: 597-601, 1987
12. Eddy, H. A., and Casarett, G. W. Development of the vascular system in the hamster malignant neurilemoma. Microvasc Res., 6: 63-82, 1973.
13. Brown, J. M. Evidence for acutely hypoxic cells in mouse tumors, and a possible mechanism for reoxygenation. Br J. Radiol., 52: 650-656, 1979.
14. Yamaura, H., and Matsuzawa, T. Tumor regrowth after irradiation. An experimental approach. Int. J. Radiat. Biol., 35: 201-219, 1979
15. Trotter, M. J., Chaplin, D. J., and Olive, P. L. Possible mechanisms for intermittent blood flow in the murine SCCVII carcinoma. Int. J. Radiat. Biol , 60, 139-146, 1991.
16. Papenfuss, D., Gross, J. F., Intaglietta, M., and Treese, F. A. A transparent access chamber for the rat dorsal skin fold. Microvasc. Res., 18, 311-318, 1979.
17. Linsenmeier, R. A., and Yancey, C. M. Improved fabrication of double-barreled recessed cathode oxygen microelectrodes. J. Appl. Physiol., 63: 2554-2557, 1987.
18. Unthank, J. L., Lash, J. M., Nixon, J C., Sidner, R. A., and Bohlen, H G. Evaluation of carbocyanine-labeled erythrocytes for microvascular measurements. Microvasc. Res., 45: 193-210, 1993
19. Brizel, D. M., Klitzman, B., Cook, J. M., Edwards, J , Rosner, G., and Dewhirst, M. W. A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. Int. J Radiat. Oncol. Biol. Phys., 25: 269-276, 1993.
20. Szoka, F. C., and Papahadjopoulos, D. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu. Rev. Biophys. Bioeng., 9: 467-508, 1980.
21. Dewhirst, M. W., Vinuya, R. Z., Ong, E. T., Klitzman, B., Rosner, G., Secomb, T. W., and Gross, J. F. Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature. Radiat. Res., 130: 345-354, 1992.
22. Hsu, R., and Secomb, T. W. A Green's function method for analysis of oxygen delivery to tissue by microvascular networks. Math. Biosci., 96. 61-78, 1989.
23. Dewhirst, M. W , Secomb, T W., Ong, E. T., Hsu, R., and Gross, J. F. Determination of local oxygen consumption rates in tumors. Cancer Res., 54: 3333-3336, 1994
24. Secomb, T W , Hsu, R., Dewhirst, M W., Klitzman, B., and Gross, J. F. Analysis of oxygen transport to tumor tissue by microvascular networks. Int J. Radiat Oncol. Biol Phys., 25. 481-489, 1993.
25. Dewhirst, M. W , Ong, E. T., Rosner, G L., Rehmus, S. W., Shan, S., Braun, R. D., Brizel, D. M., and Secomb, T. W. Arteriolar oxygenation in tumour and subcutaneous arterioles effects of inspired air oxygen content. Br. J. Cancer, 74: S241-S246, 1996.
26. Smith, T. L., Osborne, S. W., and Hutchins, P. M. Long-term micro- and macrocirculatory measurements in conscious rats. Microvasc. Res., 29: 360-370, 1985.
27. Dewhirst, M W., Kimura, H., Rehmus, S. W. E., Braun, R. D., Papahadjopoulos, D., Hong, K , and Secomb, T. W. Microvascular studies on the origins of perfusion-limited hypoxia. Br. J. Cancer, 74: S247-S251, 1996.
28. Patan, S., Munn, L. L , and Jain, R. K. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc. Res., 5: 260-272, 1996
29. Li, X , Brown, S L., and Hill, R. P. Factors influencing the thermosensitivity of two rodent tumors. Radiat. Res., 130: 211-219, 1992.
30. Chaplin, D J , and Hill, S A. Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours Br. J Cancer, 71: 1210-1213, 1995.
31. Hill, S. A., Pigott, K. H., Saunders, M. I., Powell, M. E. B., Arnold, S., Obeid, A., Ward, G., Leahy, M , Hoskin, P. J , and Chaplin, D. J. Microregional blood flow in murine and human tumours assessed using laser Doppler microprobes Br. J Cancer, 74: S260-S263, 1996.
32. Cline, J. M., Thrall, D. E., Page, R L., Franko, A. J , and Raleigh, J. A Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours Br. J Cancer, 62: 925-931, 1990.
33. Brown, J. M., and Koong, A. Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J. Natl. Cancer Inst., 83: 178-185, 1991.
34. Horsman, M R , Khalil, A A., Siemann, D. W., Grau, C., Hill, S. A., Lynch, E. M., Chaplin, D. J., and Overgaard, J. Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation. Int. J Radiat. Oncol. Biol. Phys , 29. 439-442, 1994
35. Fenton, B M., Kiani, M. F., and Siemann, D. W. Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int. J Radiat. Oncol. Biol. Phys., 33: 365-373, 1995.
36. Gatenby, R. A., Kassler, H. B., Rosenblum, J. S., Coia, L. R., Moldofsky, P. J., Hartz, W. H., and Broder, C J Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 14: 831-838, 1988.
37. Hockel, M., Knoop, C., Schlenger, K., Vorndran, B., Baußmann, E., Mitze, M., Knapstein, P., and Vaupel, P. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix Radiother. Oncol., 26, 45-50, 1993.
38. Welbourn, C. R., Goldman, G., Paterson, I S., Valeri, C. R , Shepro, D., and Hechtman, H. B. Pathophysiology of ischemia reperfusion injury: central role of the neutrophil. Br. J Surg., 78: 651-655, 1991.