Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer

Oncogene

Volumn 24, Issue 43, 2005, Pages 6555-6563

  Zhu, Yonghua ^a   Denhardt, David T ^b   Cao, Hongbin ^a   Sutphin, Patrick D ^a   Koong, Albert C ^a   Giaccia, Amato J ^a   Le, Quynh Thu ^a  

^a STANFORD UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Akt; Hypoxia; Osteopontin; ras; Regulation

Indexed keywords

DACTINOMYCIN; DNA; MESSENGER RNA; OSTEOPONTIN; PROTEIN KINASE B; RAS PROTEIN; ONCOPROTEIN; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; SIALOGLYCOPROTEIN; SPP1 PROTEIN, MOUSE;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; ENHANCER REGION; GEL MOBILITY SHIFT ASSAY; GENE DELETION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HYPOXIC CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL HYPOXIA; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MOUSE; RNA STABILITY; SQUAMOUS CELL CARCINOMA;

3T3 CELLS; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; DACTINOMYCIN; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, RAS; HEAD AND NECK NEOPLASMS; MICE; OSTEOPONTIN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RESPONSE ELEMENTS; RNA STABILITY; RNA, MESSENGER; SIALOGLYCOPROTEINS; TRANSCRIPTION, GENETIC;

EID: 26944478634     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208800     Document Type: Article

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