Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas

International Journal of Radiation Oncology Biology Physics

Volumn 54, Issue 1, 2002, Pages 215-228

  Ljungkvist, Anna S E ^a   Bussink, Johan ^a   Rijken, Paulus F J W ^a   Kaanders, Johannes H A M ^a   Van der Kogel, Albert J ^a   Denekamp, Juliana ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Hypoxia; Image analysis; Proliferation; Tumors; Xenografts

Indexed keywords

FRACTIONATION; IMAGE ANALYSIS;

CELL CARCINOMA;

ONCOLOGY;

CELL MARKER; HOE 33342; OXYGEN; PIMONIDAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCULATION; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; HYPOXIA; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OXYGEN TENSION; PERFUSION; PHYSIOLOGY; PRIORITY JOURNAL; SCORING SYSTEM; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; TUMOR CELL; TUMOR VASCULARIZATION; XENOGRAFT;

ANIMALS; BROMODEOXYURIDINE; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL HYPOXIA; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036716726     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)02938-3     Document Type: Article

References (73)

1. The histological structure of some human lung cancers and the possible implications for radiotherapy
2. Regional variation in the oxygenation of mouse mammary tumours in vivo demonstrated by fluorescence of pyridine nucleotide
3. Dynamics of microvascular flow in implanted mouse mammary tumours
4. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
5. Microvascular corrosion casting in the study of tumor vascularity: A review
6. A marker for hypoxic cells in tumours with potential clinical applicability
7. 2 tension measurements
8. 2 predicts survival in advanced cancer of the uterine cervix
9. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]
10. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
11. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
12. Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line
13. Optical sensor-based oxygen tension measurements correspond with hypoxia marker binding in three human tumor xenograft lines
14. A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas
15. Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas
16. Synthesis of deoxy-ribonucleic acid in normal and irradiated cells and its relation to chromosome breakage
17. Predictive assays of tumor radiocurability
18. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
19. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample
20. Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts
21. Tumour proliferation assessed by combined histological and flow cytometric analysis: Implications for therapy in squamous cell carcinoma in the head and neck
22. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays
23. Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry
24. Factors influencing the estimates of proliferative labelling indices in rectal cancer
25. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
26. Tumour cell proliferation in relation to the vasculature
27. Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: Effects of carbogen and nicotinamide
28. Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: A quantitative multi-parameter analysis
29. Angiogenesis as a prognostic marker in early head and neck cancer
30. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
31. Low vascular density indicates poor response to radiotherapy in small glottic carcinomas
32. Tumor angiogenesis and prognosis in squamous cell carcinoma of the head and neck
33. Intratumoral microvessel density and p53 protein: Correlation with metastasis in head-and-neck squamous-cell carcinoma
34. The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck
35. Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma of the tongue
36. Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis
37. Tumor vascularization and prognosis in squamous cell carcinomas of the esophagus
38. Tumor angiogenesis as a prognostic factor in early oral tongue cancer
39. Immunohistochemical study of tumour angiogenesis in oral squamous cell carcinoma
40. Tumor angiogenesis as a prognostic factor in laryngeal cancer
41. Vascular endothelial growth factor in squamous cell head and neck carcinoma: Expression and prognostic significance
42. Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx
43. Loss of local control with prolongation in radiotherapy
44. The hazard of accelerated tumor clonogen repopulation during radiotherapy
45. Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
46. Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors
47. Vascular density in melanoma xenografts correlates with vascular permeability factor expression but not with metastatic potential
48. Delayed vascular changes after antiangiogenic therapy with antivascular endothelial growth factor antibodies in human glioma xenografts in nude mice
49. Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts
50. Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse
51. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
52. A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer
53. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: Results of the EORTC 22851 randomized trial
54. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: Tumor dose-response and repopulation
55. Regeneration in cervix cancer after 252Cf neutron brachytherapy
56. Conventional radiotherapy as primary treatment of squamous cell carcinoma of the head and neck. A randomized multicenter study of 5 versus 6 fractions per week. Report from the DAHANCA 7 trial
57. Cancer vascularization: Implications in radiotherapy?
58. Studies with bromodeoxyuridine in head and neck cancer and accelerated radiotherapy
59. Patterns of proliferation related to vasculature in human head-and-neck carcinomas before and after transplantation in nude mice
60. Distribution of the hypoxia marker CCI-103F in canine tumors
61. Intratumour heterogeneity in microvessel oxyhaemoglobin saturations
62. 2 gradients in window chamber tumours: Impact on tumour hypoxia
63. Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe
64. Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle
65. Differential expression of clusterin in inducible models of apoptosis
66. Simultaneous triple staining for hypoxia, proliferation, and DNA content in murine tumours
67. The relationship between proliferative and oxygenation status in spontaneous canine tumors
68. Distribution of hypoxia and proliferation associated markers in spontaneous canine tumors
69. Pimonidazole: A novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma
70. The effect of hypoxia on the generation time of mammalian cells
71. Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: Modifications induced by low concentrations of misonidazole present during hypoxia
72. Evidence for intermittent radiobiological hypoxia in experimental tumour systems