메뉴 건너뛰기




Volumn 1773, Issue 10, 2007, Pages 1558-1571

Intermittent hypoxia changes HIF-1α phosphorylation pattern in endothelial cells: Unravelling of a new PKA-dependent regulation of HIF-1α

Author keywords

HIF 1 ; Intermittent hypoxia; Neo angiogenesis; PKA; Tumor

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44;

EID: 34848884803     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2007.06.002     Document Type: Article
Times cited : (62)

References (70)
  • 1
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
    • (2003) Nat. Med. , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 6
    • 0034979159 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
    • Dor Y., Porat R., and Keshet E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am. J. Physiol., Cell Physiol. 280 (2001) C1367-C1374
    • (2001) Am. J. Physiol., Cell Physiol. , vol.280
    • Dor, Y.1    Porat, R.2    Keshet, E.3
  • 7
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R., and Folkman J. Clinical translation of angiogenesis inhibitors. Nat. Rev., Cancer 2 (2002) 727-739
    • (2002) Nat. Rev., Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 8
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., and Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat. Rev., Cancer 3 (2003) 401-410
    • (2003) Nat. Rev., Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 9
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies
    • Eberhard A., Kahlert S., Goede V., Hemmerlein B., Plate K.H., and Augustin H.G. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res. 60 (2000) 1388-1393
    • (2000) Cancer Res. , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 10
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L.E., Golijanin D., Itin A., Pode D., and Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103 (1999) 159-165
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 12
    • 0035700693 scopus 로고    scopus 로고
    • Clinical relevance of intermittent tumour blood flow
    • Dur R.E., and Aquino-Parsons C. Clinical relevance of intermittent tumour blood flow. Acta Oncol. 40 (2001) 929-936
    • (2001) Acta Oncol. , vol.40 , pp. 929-936
    • Dur, R.E.1    Aquino-Parsons, C.2
  • 13
    • 0035682917 scopus 로고    scopus 로고
    • Non-constant tumour blood flow-implications for therapy
    • Dur R.E., and Aquino-Parsons C. Non-constant tumour blood flow-implications for therapy. Acta Oncol. 40 (2001) 862-869
    • (2001) Acta Oncol. , vol.40 , pp. 862-869
    • Dur, R.E.1    Aquino-Parsons, C.2
  • 14
    • 4344707313 scopus 로고    scopus 로고
    • Quantifying transient hypoxia in human tumor xenografts by flow cytometry
    • Bennewith K.L., and Durand R.E. Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res. 64 (2004) 6183-6189
    • (2004) Cancer Res. , vol.64 , pp. 6183-6189
    • Bennewith, K.L.1    Durand, R.E.2
  • 15
    • 0034660890 scopus 로고    scopus 로고
    • Fractals and cancer
    • Baish J.W., and Jain R.K. Fractals and cancer. Cancer Res. 60 (2000) 3683-3688
    • (2000) Cancer Res. , vol.60 , pp. 3683-3688
    • Baish, J.W.1    Jain, R.K.2
  • 17
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger R.H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16 (2002) 1151-1162
    • (2002) FASEB J. , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 18
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 5510-5514
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 19
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang G.L., and Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270 (1995) 1230-1237
    • (1995) J. Biol. Chem. , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 20
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S., and Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272 (1997) 22642-22647
    • (1997) J. Biol. Chem. , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 21
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
    • Semenza G.L. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107 (2001) 1-3
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 26
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang B.H., Rue E., Wang G.L., Roe R., and Semenza G.L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 271 (1996) 17771-17778
    • (1996) J. Biol. Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 27
    • 0034107952 scopus 로고    scopus 로고
    • Mammalian oxygen sensing, signalling and gene regulation
    • Wenger R.H. Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 203 (2000) 1253-1263
    • (2000) J. Exp. Biol. , vol.203 , pp. 1253-1263
    • Wenger, R.H.1
  • 28
    • 0035694958 scopus 로고    scopus 로고
    • Intermittent blood flow in solid tumours-An under-appreciated source of 'drug resistance'
    • Durand R.E. Intermittent blood flow in solid tumours-An under-appreciated source of 'drug resistance'. Cancer Metastasis Rev. 20 (2001) 57-61
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 57-61
    • Durand, R.E.1
  • 29
    • 0032756201 scopus 로고    scopus 로고
    • Inducible repair and the two forms of tumour hypoxia-time for a paradigm shift
    • Denekamp J., and Dasu A. Inducible repair and the two forms of tumour hypoxia-time for a paradigm shift. Acta Oncol. 38 (1999) 903-918
    • (1999) Acta Oncol. , vol.38 , pp. 903-918
    • Denekamp, J.1    Dasu, A.2
  • 30
    • 0029024240 scopus 로고
    • Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours
    • Chaplin D.J., and Hill S.A. Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br. J. Cancer 71 (1995) 1210-1213
    • (1995) Br. J. Cancer , vol.71 , pp. 1210-1213
    • Chaplin, D.J.1    Hill, S.A.2
  • 33
    • 0030200651 scopus 로고    scopus 로고
    • Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry
    • Pigott K.H., Hill S.A., Chaplin D.J., and Saunders M.I. Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry. Radiother. Oncol. 40 (1996) 45-50
    • (1996) Radiother. Oncol. , vol.40 , pp. 45-50
    • Pigott, K.H.1    Hill, S.A.2    Chaplin, D.J.3    Saunders, M.I.4
  • 34
    • 33846204728 scopus 로고    scopus 로고
    • Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies
    • Martinive P., Defresne F., Bouzin C., Saliez J., Lair F., Gregoire V., Michiels C., Dessy C., and Feron O. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Res. 66 (2006) 11736-11744
    • (2006) Cancer Res. , vol.66 , pp. 11736-11744
    • Martinive, P.1    Defresne, F.2    Bouzin, C.3    Saliez, J.4    Lair, F.5    Gregoire, V.6    Michiels, C.7    Dessy, C.8    Feron, O.9
  • 35
    • 0001637870 scopus 로고
    • Permanent cell line expressing human factor VIII-related antigen established by hybridization
    • Edgell C.J., McDonald C.C., and Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 3734-3737
    • (1983) Proc. Natl. Acad. Sci. U. S. A. , vol.80 , pp. 3734-3737
    • Edgell, C.J.1    McDonald, C.C.2    Graham, J.B.3
  • 38
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
    • Mottet D., Dumont V., Deccache Y., Demazy C., Ninane N., Raes M., and Michiels C. Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J. Biol. Chem. 278 (2003) 31277-31285
    • (2003) J. Biol. Chem. , vol.278 , pp. 31277-31285
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3    Demazy, C.4    Ninane, N.5    Raes, M.6    Michiels, C.7
  • 39
    • 17844364429 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I
    • Treins C., Giorgetti-Peraldi S., Murdaca J., Monthouel-Kartmann M.N., and Van Obberghen E. Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. Mol. Endocrinol. 19 (2005) 1304-1317
    • (2005) Mol. Endocrinol. , vol.19 , pp. 1304-1317
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Monthouel-Kartmann, M.N.4    Van Obberghen, E.5
  • 40
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard D.E., Berra E., Gothie E., Roux D., and Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274 (1999) 32631-32637
    • (1999) J. Biol. Chem. , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 42
    • 1842691021 scopus 로고    scopus 로고
    • PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
    • Zhou J., Schmid T., Frank R., and Brune B. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J. Biol. Chem. 279 (2004) 13506-13513
    • (2004) J. Biol. Chem. , vol.279 , pp. 13506-13513
    • Zhou, J.1    Schmid, T.2    Frank, R.3    Brune, B.4
  • 43
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
    • Arsham A.M., Plas D.R., Thompson C.B., and Simon M.C. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J. Biol. Chem. 277 (2002) 15162-15170
    • (2002) J. Biol. Chem. , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 44
    • 33646560932 scopus 로고    scopus 로고
    • Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1
    • Batmunkh C., Krajewski J., Jelkmann W., and Hellwig-Burgel T. Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1. FEBS Lett. 580 (2006) 3153-3160
    • (2006) FEBS Lett. , vol.580 , pp. 3153-3160
    • Batmunkh, C.1    Krajewski, J.2    Jelkmann, W.3    Hellwig-Burgel, T.4
  • 45
    • 0028891906 scopus 로고
    • The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
    • Kvietikova I., Wenger R.H., Marti H.H., and Gassmann M. The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res. 23 (1995) 4542-4550
    • (1995) Nucleic Acids Res. , vol.23 , pp. 4542-4550
    • Kvietikova, I.1    Wenger, R.H.2    Marti, H.H.3    Gassmann, M.4
  • 46
    • 0027959825 scopus 로고
    • Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells
    • Marti H.H., Jung H.H., Pfeilschifter J., and Bauer C. Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells. Pflugers Arch. 429 (1994) 216-222
    • (1994) Pflugers Arch. , vol.429 , pp. 216-222
    • Marti, H.H.1    Jung, H.H.2    Pfeilschifter, J.3    Bauer, C.4
  • 47
    • 33644867986 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation modulates cytochrome C oxidase function and augments hypoxia and myocardial ischemia related injury
    • Prabu S.K., Anandatheerthavarada H.K., Raza H., Srinivasan S., Spear J.F., and Avadhani N.G. Protein kinase A-mediated phosphorylation modulates cytochrome C oxidase function and augments hypoxia and myocardial ischemia related injury. J. Biol. Chem. 281 (2005) 2061-2070
    • (2005) J. Biol. Chem. , vol.281 , pp. 2061-2070
    • Prabu, S.K.1    Anandatheerthavarada, H.K.2    Raza, H.3    Srinivasan, S.4    Spear, J.F.5    Avadhani, N.G.6
  • 48
    • 29644440060 scopus 로고    scopus 로고
    • Enhanced phosphorylation of cyclic AMP response element binding protein in the brain of mice following repetitive hypoxic exposure
    • Gao Y., Gao G., Long C., Han S., Zu P., Fang L., and Li J. Enhanced phosphorylation of cyclic AMP response element binding protein in the brain of mice following repetitive hypoxic exposure. Biochem. Biophys. Res. Commun. 340 (2006) 661-667
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 661-667
    • Gao, Y.1    Gao, G.2    Long, C.3    Han, S.4    Zu, P.5    Fang, L.6    Li, J.7
  • 49
    • 0029884640 scopus 로고    scopus 로고
    • Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells
    • Takagi H., King G.L., Ferrara N., and Aiello L.P. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Investig. Ophthalmol. Vis. Sci. 37 (1996) 1311-1321
    • (1996) Investig. Ophthalmol. Vis. Sci. , vol.37 , pp. 1311-1321
    • Takagi, H.1    King, G.L.2    Ferrara, N.3    Aiello, L.P.4
  • 50
    • 0029840035 scopus 로고    scopus 로고
    • Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
    • Takagi H., King G.L., Robinson G.S., Ferrara N., and Aiello L.P. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Investig. Ophthalmol. Vis. Sci. 37 (1996) 2165-2176
    • (1996) Investig. Ophthalmol. Vis. Sci. , vol.37 , pp. 2165-2176
    • Takagi, H.1    King, G.L.2    Robinson, G.S.3    Ferrara, N.4    Aiello, L.P.5
  • 51
    • 0034128083 scopus 로고    scopus 로고
    • Adenosine and muscle vasodilatation in acute systemic hypoxia
    • Marshall J.M. Adenosine and muscle vasodilatation in acute systemic hypoxia. Acta Physiol. Scand. 168 (2000) 561-573
    • (2000) Acta Physiol. Scand. , vol.168 , pp. 561-573
    • Marshall, J.M.1
  • 53
    • 23044510839 scopus 로고    scopus 로고
    • Growth regulation of the vascular system: an emerging role for adenosine
    • Adair T.H. Growth regulation of the vascular system: an emerging role for adenosine. Am. J. Physiol., Regul. Integr. Comp. Physiol. 289 (2005) R283-R296
    • (2005) Am. J. Physiol., Regul. Integr. Comp. Physiol. , vol.289
    • Adair, T.H.1
  • 55
    • 0029921939 scopus 로고    scopus 로고
    • Adenosine physiology and pharmacology: how about A2 receptors?
    • Daval J.L., Nicolas F., and Doriat J.F. Adenosine physiology and pharmacology: how about A2 receptors?. Pharmacol. Ther. 71 (1996) 325-335
    • (1996) Pharmacol. Ther. , vol.71 , pp. 325-335
    • Daval, J.L.1    Nicolas, F.2    Doriat, J.F.3
  • 56
    • 0027478599 scopus 로고
    • Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia
    • Michiels C., Arnould T., Knott I., Dieu M., and Remacle J. Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. Am. J. Physiol. 264 (1993) C866-C874
    • (1993) Am. J. Physiol. , vol.264
    • Michiels, C.1    Arnould, T.2    Knott, I.3    Dieu, M.4    Remacle, J.5
  • 57
    • 0037081745 scopus 로고    scopus 로고
    • Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors
    • Michiels C., Renard P., Bouaziz N., Heck N., Eliaers F., Ninane N., Quarck R., Holvoet P., and Raes M. Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors. Biochem. Pharmacol. 63 (2002) 321-332
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 321-332
    • Michiels, C.1    Renard, P.2    Bouaziz, N.3    Heck, N.4    Eliaers, F.5    Ninane, N.6    Quarck, R.7    Holvoet, P.8    Raes, M.9
  • 59
    • 0036794517 scopus 로고    scopus 로고
    • Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies
    • Ray C.J., Abbas M.R., Coney A.M., and Marshall J.M. Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. J. Physiol. 544 (2002) 195-209
    • (2002) J. Physiol. , vol.544 , pp. 195-209
    • Ray, C.J.1    Abbas, M.R.2    Coney, A.M.3    Marshall, J.M.4
  • 60
    • 33645990346 scopus 로고    scopus 로고
    • The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium
    • Ray C.J., and Marshall J.M. The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. J. Physiol. 570 (2006) 85-96
    • (2006) J. Physiol. , vol.570 , pp. 85-96
    • Ray, C.J.1    Marshall, J.M.2
  • 61
    • 3242740249 scopus 로고    scopus 로고
    • Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells
    • Yuan G., Adhikary G., McCormick A.A., Holcroft J.J., Kumar G.K., and Prabhakar N.R. Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells. J. Physiol. 557 (2004) 773-783
    • (2004) J. Physiol. , vol.557 , pp. 773-783
    • Yuan, G.1    Adhikary, G.2    McCormick, A.A.3    Holcroft, J.J.4    Kumar, G.K.5    Prabhakar, N.R.6
  • 62
    • 33847267684 scopus 로고    scopus 로고
    • A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation
    • Ryan S., McNicholas W.T., and Taylor C.T. A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochem. Biophys. Res. Commun. 355 (2007) 728-733
    • (2007) Biochem. Biophys. Res. Commun. , vol.355 , pp. 728-733
    • Ryan, S.1    McNicholas, W.T.2    Taylor, C.T.3
  • 63
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., and Semenza G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60 (2000) 1541-1545
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 66
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., and Bruick R.K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16 (2002) 1466-1471
    • (2002) Genes Dev. , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 67
    • 0042564792 scopus 로고    scopus 로고
    • S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity
    • Yasinska I.M., and Sumbayev V.V. S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity. FEBS Lett. 549 (2003) 105-109
    • (2003) FEBS Lett. , vol.549 , pp. 105-109
    • Yasinska, I.M.1    Sumbayev, V.V.2
  • 68
    • 0035855668 scopus 로고    scopus 로고
    • Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
    • Suzuki H., Tomida A., and Tsuruo T. Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 20 (2001) 5779-5788
    • (2001) Oncogene , vol.20 , pp. 5779-5788
    • Suzuki, H.1    Tomida, A.2    Tsuruo, T.3
  • 69
    • 0022592496 scopus 로고
    • Changes in intracellular pH induced by hyperthermia and hypoxia
    • Vexler A.M., and Litinskaya L.L. Changes in intracellular pH induced by hyperthermia and hypoxia. Int. J. Hypertherm. 2 (1986) 75-81
    • (1986) Int. J. Hypertherm. , vol.2 , pp. 75-81
    • Vexler, A.M.1    Litinskaya, L.L.2
  • 70
    • 33644873854 scopus 로고    scopus 로고
    • Antiangiogenic agent SU6668 suppresses the tumor growth of xenografted A-431 cells
    • Nakamura T., Ozawa S., Kitagawa Y., Ueda M., Kubota T., and Kitajima M. Antiangiogenic agent SU6668 suppresses the tumor growth of xenografted A-431 cells. Oncol. Rep. 15 (2006) 79-83
    • (2006) Oncol. Rep. , vol.15 , pp. 79-83
    • Nakamura, T.1    Ozawa, S.2    Kitagawa, Y.3    Ueda, M.4    Kubota, T.5    Kitajima, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.