Hypoxia-inducible factor-1α stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion

Molecular Biology of the Cell

Volumn 19, Issue 1, 2008, Pages 86-94

  Page, Elisabeth L ^a   Chan, Denise A ^b   Giaccia, Amato J ^b   Levine, Mark ^c   Richard, Darren E ^a  

^a LAVAL UNIVERSITY   (Canada)

^b STANFORD UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGENASE; PROLINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYDROXYLATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; UBIQUITINATION; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMALS; ASCORBIC ACID; CELL HYPOXIA; COENZYMES; HALF-LIFE; HUMANS; HYDROGEN PEROXIDE; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SPACE; MALE; OXIDATION-REDUCTION; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; THERMODYNAMICS; UBIQUITINATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 38749106115     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-06-0612     Document Type: Article

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