Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI

Magnetic Resonance in Medicine

Volumn 58, Issue 3, 2007, Pages 473-481

  Brurberg, Kjetil G ^a   Benjaminsen, Ilana C ^a   Dørum, Liv M R ^a   Rofstad, Einar K ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Blood perfusion; Kety analysis; Melanoma xenografts

Indexed keywords

DERMATOLOGY; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; ONCOLOGY; TUMORS;

BLOOD PERFUSION; DYNAMIC CONTRAST ENHANCED MRI; EXPERIMENTAL PROCEDURE; EXTRACTION FRACTIONS; KETY ANALYSIS; MELANOMA XENOGRAFTS; PARTITION COEFFICIENT; TEMPORAL HETEROGENEITIES;

BLOOD;

GADOLINIUM PENTETATE MEGLUMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGE PROCESSING; MELANOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION; REPRODUCIBILITY; TUMOR BLOOD FLOW; XENOGRAFT;

EID: 35148853125     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21367     Document Type: Article

References (40)

1. 2 saturations, perfusion and hypoxia in spontaneous and transplanted tumor models. Int J Cancer 2001;93:693-698.
2. Jain RK. Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev 1997;26:71-90.
3. 1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223-232.
4. Larsson HB, Stubgaard M, Sondergaard L, Henriksen O. In vivo quantification of the unidirectional influx constant for Gd-DTPA diffusion across the myocardial capillaries with MR imaging. J Magn Reson Imaging 1994;4:433-440.
5. Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O. Myocardial perfusion modeling using MRI. Magn Reson Med 1996;35:716-726.
6. Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988;48:2641-2658.
7. Benjaminsen IC, Graff BA, Brurberg KG, Rofstad EK. Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts. Magn Reson Med 2004;52:269-276.
8. Graff BA, Benjaminsen IC, Brurberg KG, Ruud EBM, Rofstad EK. Comparison of tumor blood perfusion assessed by dynamic contrast-enhanced MRI with tumor blood supply assessed by invasive imaging. J Magn Reson Imaging 2005;21:272-281.
9. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 1998;58:1408-1416.
10. Horsman MR. Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. A review. Acta Oncol 1995;34:571-587.
11. Brown JM. The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 1999;59:5863-5870.
12. Kimura H, Braun RD, Ong ET, Hsu R, Secomb TW, Papahadjopoulos D, Hong K, Dewhirst MW. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 1996;56:5522-5528.
13. 2 of R3230AC tumors in Fischer-344 rats. Int J Radiat Oncol Biol Phys 1998;42:723-726.
14. Brurberg KG, Graff BA, Rofstad EK. Temporal heterogeneity in oxygen tension in human melanoma xenografts. Br J Cancer 2003;89:350-356.
15. Wouters BG, Weppler SA, Koritzinsky M, Landuyt W, Nuyts S, Theys J, Chiu RK, Lambin P. Hypoxia as a target for combined modality treatments. Eur J Cancer 2002;38:240-257.
16. Rofstad EK. Microenvironment-induced cancer metastasis. Int J Radiat Biol 2000;76:589-605.
17. Höckel M, Schlenger K, Mitze M, Schaffer U, Vaupel P. Hypoxia and radiation response in human tumors. Semin Radiat Oncol 1996;6:3-9.
18. Nordsmark M, Overgaard J. Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer. Acta Oncol 2004;43:396-403.
19. Chaplin DJ, Durand RE, Olive PL. Acute hypoxia in tumors: implications for modifiers of radiation effects. Int J Radiat Oncol Biol Phys 1986;12:1279-1282.
20. Bennewith KL, Raleigh JA, Durand RE. Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res 2002;62:6827-6830.
21. 2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia? Phys Med Biol 2004;49:3389-3411.
22. Dewhirst MW, Kimura H, Rehmus SW, Braun RD, Papahadjopoulos D, Hong K, Secomb TW. Microvascular studies on the origins of perfusion-limited hypoxia. Br J Cancer Suppl 1996;27:S247-S251.
23. 2 fluctuations in human melanoma xenografts. Int J Radiat Oncol Biol Phys 2004;58:403-409.
24. Rofstad EK, Måseide K. Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours. Int J Radiat Biol 1999;75:1377-1393.
25. Rofstad EK. Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br J Cancer 1994;70:804-812.
26. Lyng H, Dahle GA, Kaalhus O, Skretting A, Rofstad EK. Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging. Magn Reson Med 1998;40:89-98.
27. Hittmair K, Gomiscek G, Langenberger K, Recht M, Imhof H, Kramer J. Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI. Magn Reson Med 1994;31:567-571.
28. Kety S. Theory of blood-tissue exchange and its application to measurements of blood flow. Methods Med Res 1960;8:228-236.
29. Braun RD, Lanzen JL, Dewhirst MW. Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am J Physiol 1999;277:H551-H568.
30. Egeland TAM, Gaustad JV, Vestvik IK, Benjaminsen IC, Mathiesen B, Rofstad EK. Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn Reson Med 2006;55:874-882.
31. Dewhirst MW. Concepts of oxygen transport at the microcirculatory level. Semin Radiat Oncol 1998;8:143-150.
32. e imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med 2006;55:309-315.
33. Gaustad JV, Benjaminsen IC, Graff BA, Brurberg KG, Ruud EB, Rofstad EK. Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 2005;21:792-800.
34. Graff BA, Kvinnsland Y, Skretting A, Rofstad EK. Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts. Br J Cancer 2003;88:291-297.
35. Tufto I, Lyng H, Rofstad EK. Vascular density in human melanoma xenografts: relationship to angiogenesis, perfusion and necrosis. Cancer Lett 1998;123:159-165.
36. Måseide K, Rofstad EK. Intratumour heterogeneity in microvessel oxyhaemoglobin saturations. Cancer Lett 2001;162:245-251.
37. Baudelet C, Cron GO, Ansiaux R, Crokart N, Dewever J, Feron O, Gallez B. The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors. NMR Biomed 2006;19:69-76.
38. Trotter MJ, Chaplin DJ, Olive PL. Possible mechanisms for intermittent blood flow in the murine SCCVII carcinoma. Int J Radiat Biol 1991;60:139-146.
39. Tufto I, Rofstad EK. Transient perfusion in human melanoma xenografts. Br J Cancer 1995;71:789-793.
40. Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentration within the extravascular compartment of an experimental tumor. Cancer Res 2006;66:2219-2223.