Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors

Journal of Biomedical Optics

Volumn 13, Issue 1, 2008, Pages

  Sorg, Brian S ^a,b,c   Hardee, Matthew E ^b   Agarwal, Nikita ^a   Moeller, Benjamin J ^b   Dewhirst, Mark W ^b  

^a University of Florida   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

cancer; fluctuations; hemoglobin saturation; hypoxia; in vivo microscopy; microvasculature; oxygen; tumor; window chamber

Indexed keywords

CANCER; FLUCTUATIONS; HEMOGLOBIN SATURATION; HYPOXIA; IN VIVO MICROSCOPY; MICRO-VASCULATURE; WINDOW CHAMBER;

BLOOD VESSELS; HEMOGLOBIN; MICROCIRCULATION; MICROELECTRODES; OXYGEN; OXYGENATION; OXYGENATORS; VISUALIZATION;

TUMORS;

FISTULA;

OXYGEN;

ANIMAL; ARTICLE; EVALUATION; EXPERIMENTAL NEOPLASM; METABOLISM; METHODOLOGY; MICROCIRCULATION; MICROSCOPY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; MICROCIRCULATION; MICROSCOPY; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS;

EID: 44349193706     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.2837439     Document Type: Article

References (42)

1. T. M., Busch, E. P., Wileyto, S. M., Evans, and C. J., Koch, " Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections, ", Adv. Exp. Med. Biol., 510, 37-43 (2003). aem AEMBAP 0065-2598 (Pubitemid 36307751)
2. D. J., Chaplin, M. R., Horsman, M. J., Trotter, and D. W., Siemann, " Therapeutic significance of microenvironmental factors, " in, Blood Perfusion and Microenvironment of Human Tumors, M., Molls, and, P., Vaupel, Eds., pp. 133-143, Springer-Verlag, New York (1998).
3. M. W., Dewhirst, " Concepts of oxygen transport at the microcirculatory level, ", Semin. Radiat. Oncol., 8, 143-150 (1998). 8hu ZZZZZZ 1053-4296 (Pubitemid 28323473)
4. R. E., Durand and N. E., LePard, " Contribution of transient blood flow to tumor hypoxia in mice, ", Acta Oncol., 34, 317-323 (1995). aoo ACTOEL 0284-186X 10.3109/02841869509093982
5. R. K., Jain, " Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy, ", Nat. Med., 7, 987-989 (2001). 84o ZZZZZZ 1078-8956 (Pubitemid 32937367)
6. P., Vaupel, A., Mayer, S., Briest, and M., Höckel, " Hypoxia in breast cancer: Role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion, ", Adv. Exp. Med. Biol., 566, 333-342 (2005). aem AEMBAP 0065-2598 (Pubitemid 43779520)
7. M. R., Horsman and J., Overgaard, " The oxygen effect, " in, Basic Clinical Radiobiology, 2nd ed., G. G., Steel, Ed., pp. 132-140, Oxford University Press, New York (1997).
8. A. M., Shannon, D. J., Bouchier-Hayes, C. M., Condron, and D., Toomey, " Tumor hypoxia, chemotherapeutic resistance and hypoxia-related therapies, ", Cancer Treat Rev., 29, 297-307 (2003). 3za ZZZZZZ 0305-7372 (Pubitemid 37069660)
9. A. L., Harris, " Hypoxia - a key regulatory factor in tumor growth, ", Nat. Rev. Cancer, 2, 38-47 (2001). bcg NRCAC4 1474-175X 10.1038/nrc704
10. M., Höckel and P., Vaupel, " Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects, ", J. Natl. Cancer Inst., 93, 266-276 (2001). jnq JNCIEQ 0027-8874 10.1093/jnci/93.4.266 (Pubitemid 32219813)
11. H., Kimura, R. D., Braun, E. T., Ong, R., Hsu, T. W., Secomb, D., Papahadjopoulos, K., Hong, and M. W., Dewhirst, " Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma, ", Cancer Res., 56, 5522-5528 (1996). cnr CNREA8 0008-5472 (Pubitemid 27011389)
12. 2, gradients in window chamber tumours: Impact on tumour hypoxia, ", Br. J. Cancer, 79, 1717-1722 (1999). bjc BJCAAI 0007-0920 10.1038/sj.bjc.6690273 (Pubitemid 29132294)
13. R. D., Braun, J. L., Lanzen, and M. W., Dewhirst, " Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats, ", Am. J. Physiol., 277, H551-H568 (1999). ajh AJPHAP 0002-9513
14. M. W., Dewhirst, " Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting, ", Cancer Res., 67, 854-855 (2007). cnr CNREA8 0008-5472
15. P., Martinive, F., Defresne, C., Bouzin, J., Saliez, F., Lair, V., Grégoire, C., Michiels, C., Dessy, and O., Feron, " Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: Implications for anticancer therapies, ", Cancer Res., 66, 11736-11744 (2006). cnr CNREA8 0008-5472 10.1158/0008-5472.CAN-06-2056 (Pubitemid 46094185)
16. E. K., Rofstad, K., Galappathi, B., Mathiesen, and E.-B. M., Ruud, " Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis, ", Clin. Cancer Res., 13, 1971-1978 (2007). 84q ZZZZZZ 1078-0432 (Pubitemid 46649862)
17. A., Zakrzewicz, T. W., Secomb, and A. R., Pries, " Angioadaptation: Keeping the vascular system in shape, ", News Physiol. Sci., 17, 197-201 (2002). nep NEPSEY 0886-1714
18. R. K., Jain, " Determinents of tumor blood flow: A review, ", Cancer Res., 48, 2641-2658 (1988). cnr CNREA8 0008-5472
19. P., Vaupel, F., Kallinowski, and P., Okunieff, " Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review, ", Cancer Res., 49, 6449-6465 (1989). cnr CNREA8 0008-5472 (Pubitemid 20008770)
20. D. W., Siemann, " The tumor microenvironment: A double-edged sword, ", Int. J. Radiat. Oncol., Biol., Phys., 42, 697-699 (1998). ioc IOBPD3 0360-3016 10.1016/S0360-3016(98)00336-8 (Pubitemid 28559400)
21. S., Ho, W. Y., Lau, W. T., Leung, M., Chan, K. W., Chan, P. J., Johnson, and A. K. C., Li, " Arteriovenous shunts in patients with hepatic tumors, ", J. Nucl. Med., 38, 1201-1205 (1997). eaq JNMEAQ 0161-5505 (Pubitemid 27332612)
22. S. R., McDougall, A. R. A., Anderson, M. A. J., Chaplain, and J. A., Sheratt, " Mathematical modelling of flow through vascular networks: Implications for tumor-induced angiogenesis and chemotherapy strategies, ", Bull. Math. Biol., 64, 673-702 (2002). bmv BMTBAP 0092-8240 10.1006/bulm.2002.0293 (Pubitemid 36072687)
23. B. S., Sorg, B. J., Moeller, O., Donovan, Y., Cao, and M. W., Dewhirst, " Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development, ", J. Biomed. Opt., 10, 044004 (2005). jbo JBOPFO 1083-3668 10.1117/1.2003369 (Pubitemid 43328906)
24. B. S., Sorg, B. J., Moeller, O., Donovan, Y., Cao, and M. W., Dewhirst, " Measurement of hemoglobin saturation in tumor microvasculature in preclinical models using hyperspectral imaging, ", Proc. SPIE, 5694, 74-81 (2005). spi PSISDG 0277-786X (Pubitemid 41091312)
25. R. D., Shonat, E. S., Wachman, W.-H., Niu, A. P., Koretsky, and D. L., Farkas, " Near-simultaneous hemoglobin saturation and oxygen tension maps in mouse brain using an AOTF microscope, ", Biophys. J., 73, 1223-1231 (1997). bio BIOJAU 0006-3495 (Pubitemid 27360712)
26. D. C., Montgomery and E. A., Peck, Introduction to Linear Regression Analysis, Wiley-Liss, New York (1992).
27. J., Lanzen, R. D., Braun, B., Klitzman, D., Brizel, T. W., Secomb, and M. W., Dewhirst, " Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor, ", Cancer Res., 66, 2219-2223 (2006). cnr CNREA8 0008-5472 10.1158/0008-5472.CAN-03-2958
28. 2, in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy, ", Radiol. Oncol., 77, 220-226 (2005). ron RONCEM 1318-2099 (Pubitemid 41682391)
29. M. R., Horsman and D. W., Siemann, " Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies, ", Cancer Res., 24, 11520-11539 (2006). cnr CNREA8 0008-5472 10.1158/0008-5472.CAN-06-2848 (Pubitemid 46094158)
30. B. R., Duling and R. M., Berne, " Longitudinal gradients in periarteriolar oxygen tension, ", Circ. Res., 27, 669-678 (1970). cis CIRUAL 0009-7330
31. L. I., Cardenas-Navia, D., Yu, R. D., Braun, D. M., Brizel, T. W., Secomb, and M. W., Dewhirst, " Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing, ", Cancer Res., 64, 6010-6017 (2004). cnr CNREA8 0008-5472 10.1158/0008-5472.CAN-03-0947 (Pubitemid 39129398)
32. A., Colantuoni, S., Bertuglia, and M., Intaglieta, " Quantitation of rhythmic diameter changes in arterial microcirculation, ", Am. J. Physiol., 246, H508-H517 (1984). ajh AJPHAP 0002-9513
33. W. G., Hundley, G. J., Renaldo, J. E., Levasseur, and H. A., Kontos, " Vasomotion in cerebral microcirculation of awake rabbits, ", Am. J. Physiol., 254, H67-H71 (1988). ajh AJPHAP 0002-9513
34. B. D., Kavanagh, B. E., Coffey, D., Needham, R. M., Hochmuth, and M. W., Dewhirst, " The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment, ", Br. J. Cancer, 67, 734-741 (1993). bjc BJCAAI 0007-0920 (Pubitemid 23101551)
35. P., Vaupel, " Tumor blood flow, " in, Blood Perfusion and Microenvironment of Human Tumors, M., Molls, and, P., Vaupel, Eds., pp. 41-45, Springer-Verlag, Berlin (1998).
36. C., Lagergren, Å., Lindbom, and G., Söderberg, " Vascularization of fibromatous and fibrosarcomatous tumors, ", Acta Radiol. (1921-1962), 53, 1-16 (1960). arx ACRAAX 0001-6926
37. B. A., Warren, " The vascular morphology of tumors, " in, Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors, H.-I., Peterson, Ed., pp. 1-47, CRC Press, Inc., Boca Raton, Fla. (1979).
38. L., Mariani, G., Schroth, J. P., Wielepp, A., Haldemann, and R. W., Seiler, " Intratumoral arteriovenous shunting in malignant gliomas, ", Neurosurgery, 48, 353-358 (2001). 6aq ZZZZZZ 0148-396X (Pubitemid 32164875)
39. D. W., Siemann, M. R., Horsman, and D. J., Chaplin, " Modification of oxygen supply, " in, Blood Perfusion and Microenvironment of Human Tumors, M., Molls, and, P., Vaupel, Eds., pp. 209-217, Springer-Verlag, Berlin (1998).
40. P., Vaupel, D. K., Kelleher, and O., Thews, " Modulation of tumor oxygen, ", Int. J. Radiat. Oncol., Biol., Phys., 42, 843-848 (1998). ioc IOBPD3 0360-3016 10.1016/S0360-3016(98)00324-1 (Pubitemid 28559429)
41. 2, in tumors in response to carbogen breathing, ", Int. J. Radiat. Oncol., Biol., Phys., 42, 855-859 (1998). ioc IOBPD3 0360-3016 10.1016/S0360-3016(98)00312-5 (Pubitemid 28559431)
42. B., Styp-Rekowska, N. M., Disassa, B., Reglin, L., Ulm, H., Kuppe, T. W., Secomb, and A. R., Pries, " An imaging spectroscopy approach for measurement of oxygen saturation and hematocrit during intravital microscopy, ", Microcirculation (Philadelphia), 14, 207-221 (2007). mip MROCER 1073-9688 (Pubitemid 46552877)