Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span

Current Biology

Volumn 15, Issue 22, 2005, Pages 2063-2068

  Bauer, Johannes H ^a,c   Poon, Peter C ^a,c   Glatt Deeley, Heather ^a   Abrams, John M ^b   Helfand, Stephen L ^a,c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; P53 PROTEIN, DROSOPHILA; PROTEIN P53;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DROSOPHILA MELANOGASTER; ENERGY METABOLISM; FERTILITY; GENETICS; LONGEVITY; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PHYSIOLOGY;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENERGY METABOLISM; FERTILITY; LONGEVITY; NEURONS; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53;

DROSOPHILA MELANOGASTER;

EID: 27844596799     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2005.10.051     Document Type: Article

References (25)

1. S.D. Tyner, S. Venkatachalam, J. Choi, S. Jones, N. Ghebranious, H. Igelmann, X. Lu, G. Soron, B. Cooper, and C. Brayton p53 mutant mice that display early ageing-associated phenotypes Nature 415 2002 45 53
2. B. Maier, W. Gluba, B. Bernier, T. Turner, K. Mohammad, T. Guise, A. Sutherland, M. Thorner, and H. Scrable Modulation of mammalian life span by the short isoform of p53 Genes Dev. 18 2004 306 319
3. J. Campisi Between Scylla and Charybdis: p53 links tumor suppression and aging Mech. Ageing Dev. 123 2002 567 573
4. L.A. Donehower Does p53 affect organismal aging? J. Cell. Physiol. 192 2002 23 33
5. D. van Heemst, S.P. Mooijaart, M. Beekman, J. Schreuder, A.J.M. de Craen, B.W. Brandt, P.E. Slagboom, R.G.J. Westendorp, and Long Life Study Group Variation in the human TP53 gene affects old age survival and cancer mortality Exp. Gerontol. 40 2005 11 15
6. W. Nordstrom, and J.M. Abrams Guardian ancestry: fly p53 and damage-inducible apoptosis Cell Death Differ. 7 2000 1035 1038
7. C.A. Wolkow Life span: getting the signal from the nervous system Trends Neurosci. 25 2002 212 216
8. A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415
9. M.H. Brodsky, W. Nordstrom, G. Tsang, E. Kwan, G.M. Rubin, and J.M. Abrams Drosophila p53 binds a damage response element at the reaper locus Cell 101 2000 103 113
10. T. Osterwalder, K.S. Yoon, B.H. White, and H. Keshishian A conditional tissue-specific transgene expression system using inducible GAL4 Proc. Natl. Acad. Sci. USA 98 2001 12596 12601
11. G. Roman, K. Endo, L. Zong, and R.L. Davis P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster Proc. Natl. Acad. Sci. USA 98 2001 12602 12607
12. B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003
13. H.D. Wang, P. Kazemi-Esfarjani, and S. Benzer Multiple-stress analysis for isolation of Drosophila longevity genes Proc. Natl. Acad. Sci. USA 101 2004 12610 12615
14. T.E. Johnson, S. Henderson, S. Murakami, E. de Castro, S.H. de Castro, J. Cypser, B. Rikke, P. Tedesco, and C. Link Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease J. Inherit. Metab. Dis. 25 2002 197 206
15. C.Y. Li, J.B. Little, K. Hu, W. Zhang, L. Zhang, M.W. Dewhirst, and Q. Huang Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures Cancer Res. 61 2001 428 432
16. L. Partridge, and N. Prowse The effects of reproduction on longevity and fertility in male Drosophila melanogaster J. Insect Physiol. 43 1997 501 512
17. J.H. Marden, B. Rogina, K.L. Montooth, and S.L. Helfand Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies Proc. Natl. Acad. Sci. USA 100 2003 3369 3373
18. W. Mair, P. Goymer, S.D. Pletcher, and L. Partridge Demography of dietary restriction and death in Drosophila Science 301 2003 1731 1733
19. T.G. Bross, B. Rogina, and S.L. Helfand Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction Aging Cell 2005 10.1111/j.1474-9726.2005.00181.x in press. Published online November 7, 2005
20. T. Igaki, H. Kanuka, N. Inohara, K. Sawamoto, G. Nunez, H. Okano, and M. Miura Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death Proc. Natl. Acad. Sci. USA 97 2000 662 667
21. S. Jin, S. Martinek, W.S. Joo, J.R. Wortman, N. Mirkovic, A. Sali, M.D. Yandell, N.P. Pavletich, M.W. Young, and A.J. Levine Identification and characterization of a p53 homologue in Drosophila melanogaster Proc. Natl. Acad. Sci. USA 97 2000 7301 7306
22. M. Ollmann, L.M. Young, C.J. Di Como, F. Karim, M. Belvin, S. Robertson, K. Whittaker, M. Demsky, W.W. Fisher, and A. Buchman Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 Cell 101 2000 91 101
23. N. Sogame, M. Kim, and J.M. Abrams Drosophila p53 preserves genomic stability by regulating cell death Proc. Natl. Acad. Sci. USA 100 2003 4696 4701
24. T.B. Kirkwood p53 and ageing: too much of a good thing? Bioessays 24 2002 577 579
25. J. Zheng, S.W. Edelman, G. Tharmarajah, D.W. Walker, S.D. Pletcher, and L. Seroude Differential patterns of apoptosis in response to aging in Drosophila Proc. Natl. Acad. Sci. USA 102 2005 12083 12088