Determination and Modulation of Prolyl-4-Hydroxylase Domain Oxygen Sensor Activity

Methods in Enzymology

Volumn 435, Issue , 2007, Pages 43-60

  Wirthner, Renato ^a   Balamurugan, Kuppusamy ^a   Stiehl, Daniel P ^a   Barth, Sandra ^a   Spielmann, Patrick ^a   Oehme, Felix ^b   Flamme, Ingo ^b   Katschinski, Dörthe M ^c   Wenger, Roland H ^a   Camenisch, Gieri ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Institute of Cardiovascular Research   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; TISSUE EXTRACT; UBIQUITIN PROTEIN LIGASE; VON HIPPEL LINDAU PROTEIN; GLUTARIC ACID; GLUTARIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1BETA; PEPTIDE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; HYDROXYLATION; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SENSOR; THIN LAYER CHROMATOGRAPHY; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CHROMATOGRAPHY, THIN LAYER; DECARBOXYLATION; GLUTARATES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXIDATION-REDUCTION; OXYGEN; PEPTIDES; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TISSUE EXTRACTS;

EID: 39749110067     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(07)35003-9     Document Type: Review

References (50)

1. Appelhoff R.J., Tian Y.M., Raval R.R., Turley H., Harris A.L., Pugh C.W., Ratcliffe P.J., and Gleadle J.M. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 279 (2004) 38458-38465
2. Aprelikova O., Chandramouli G.V., Wood M., Vasselli J.R., Riss J., Maranchie J.K., Linehan W.M., and Barrett J.C. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. J. Cell. Biochem. 92 (2004) 491-501
3. Baek J.H., Mahon P.C., Oh J., Kelly B., Krishnamachary B., Pearson M., Chan D.A., Giaccia A.J., and Semenza G.L. OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α. Mol. Cell 17 (2005) 503-512
4. Berchner-Pfannschmidt U., Yamac H., Trinidad B., and Fandrey J. Nitric oxide modulates oxygen sensing by HIF-1 dependent induction of prolyl hydroxylase 2. J. Biol. Chem. 282 (2006) 1788-1796
5. Berra E., Benizri E., Ginouves A., Volmat V., Roux D., and Pouysségur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22 (2003) 4082-4090
6. Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97 (2000) 9082-9087
7. Cockman M.E., Lancaster D.E., Stolze I.P., Hewitson K.S., McDonough M.A., Coleman M.L., Coles C.H., Yu X., Hay R.T., Ley S.C., Pugh C.W., Oldham N.J., et al. Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl. Acad. Sci. USA 103 (2006) 14767-14772
8. D'Angelo G., Duplan E., Vigne P., and Frelin C. Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1α Pro-564 hydroxylation. J. Biol. Chem. 278 (2003) 15406-15411
9. D'Angelo G., Duplan E., Boyer N., Vigne P., and Frelin C. Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation. J. Biol. Chem. 278 (2003) 38183-38187
10. Dalgard C.L., Lu H., Mohyeldin A., and Verma A. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem. J. 380 (2004) 419-424
11. Ehrismann D., Flashman E., Genn D.N., Mathioudakis N., Hewitson K.S., Ratcliffe P.J., and Schofield C.J. Studies on the activity of the hypoxia-inducible factor hydroxylases using an oxygen consumption assay. Biochem. J. 401 (2006) 227-234
12. Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., Tian Y.M., Masson Y.M., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107 (2001) 43-54
13. Gerald D., Berra E., Frapart Y.M., Chan D.A., Giaccia A.J., Mansuy D., Pouysségur J., Yaniv M., and Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118 (2004) 781-794
14. Hagen T., Taylor C.T., Lam F., and Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1α. Science 302 (2003) 1975-1978
15. Hewitson K.S., McNeill L.A., Riordan M.V., Tian Y.M., Bullock A.N., Welford R.W., Elkins J.M., Oldham N.J., Bhattacharya S., Gleadle J.M., Ratcliffe P.J., Pugh C.W., et al. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277 (2002) 26351-26355
16. Hirsilä M., Koivunen P., Günzler V., Kivirikko K.I., and Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278 (2003) 30772-30780
17. Hirsilä M., Koivunen P., Xu L., Seeley T., Kivirikko K.I., and Myllyharju J. Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J. 19 (2005) 1308-1310
18. Hopfer U., Hopfer H., Jablonski K., Stahl R.A., and Wolf G. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). J. Biol. Chem. 281 (2006) 8645-8655
19. Ivan M., Haberberger T., Gervasi D.C., Michelson K.S., Günzler V., Kondo K., Yang H., Sorokina I., Conaway R.C., Conaway J.W., and Kaelin Jr. W.G. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA 99 (2002) 13459-13464
20. Karaczyn A., Ivanov S., Reynolds M., Zhitkovich A., Kasprzak K.S., and Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J. Cell. Biochem. 97 (2006) 1025-1035
21. 14C]succinate: Application to prolyl 4-hydroxylase. Anal. Biochem. 184 (1990) 291-297
22. Knowles H.J., Raval R.R., Harris A.L., and Ratcliffe P.J. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res. 63 (2003) 1764-1768
23. Koivunen P., Hirsilä M., Kivirikko K.I., and Myllyharju J. The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J. Biol. Chem. 281 (2006) 28712-28720
24. Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., and Bruick R.K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16 (2002) 1466-1471
25. Linden T., Katschinski D.M., Eckhardt K., Scheid A., Pagel H., and Wenger R.H. The antimycotic ciclopirox olamine induces HIF-1α stability, VEGF expression, and angiogenesis. FASEB J. 17 (2003) 761-763
26. Lu H., Dalgard C.L., Mohyeldin A., McFate T., Tait A.S., and Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J. Biol. Chem. 280 (2005) 41928-41939
27. Mahon P.C., Hirota K., and Semenza G.L. FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 (2001) 2675-2686
28. Martin F., Linden T., Katschinski D.M., Oehme F., Flamme I., Mukhopadhyay C.K., Eckhardt K., Tröger J., Barth S., Camenisch G., and Wenger R.H. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: Implications for ceruloplasmin regulation. Blood 105 (2005) 4613-4619
29. Marxsen J.H., Stengel P., Doege K., Heikkinen P., Jokilehto T., Wagner T., Jelkmann W., Jaakkola P., and Metzen E. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases. Biochem. J. 381 (2004) 761-767
30. Masson N., Appelhoff R.J., Tuckerman J.R., Tian Y.M., Demol H., Puype M., Vandekerckhove J., Ratcliffe P.J., and Pugh C.W. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. FEBS Lett. 570 (2004) 166-170
31. McNeill L.A., Flashman E., Buck M.R., Hewitson K.S., Clifton I.J., Jeschke G., Claridge T.D., Ehrismann D., Oldham N.J., and Schofield C.J. Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Mol. Biosyst. 1 (2005) 321-324
32. Metzen E., Zhou J., Jelkmann W., Fandrey J., and Brüne B. Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol. Biol. Cell 14 (2003) 3470-3481
33. Metzen E., Stiehl D.P., Doege K., Marxsen J.H., Hellwig-Bürgel T., and Jelkmann W. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: Identification of a functional hypoxia-responsive element. Biochem. J. 387 (2005) 711-717
34. Myllylä R., Majamaa K., Günzler V., Hanauske-Abel H.M., and Kivirikko K.I. Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase. J. Biol. Chem. 259 (1984) 5403-5405
35. Nakayama K., Frew I.J., Hagensen M., Skals M., Habelhah H., Bhoumik A., Kadoya T., Erdjument-Bromage H., Tempst P., Frappell P.B., Bowtell D.D., Ronai Z., et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1α abundance, and modulates physiological responses to hypoxia. Cell 117 (2004) 941-952
36. Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., and Flamme I. A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity. Anal. Biochem. 330 (2004) 74-80
37. Ozer A., Wu L.C., and Bruick R.K. The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Proc. Natl. Acad. Sci. USA 102 (2005) 7481-7486
38. Percy M.J., Zhao Q., Flores A., Harrison C., Lappin T.R., Maxwell P.H., McMullin M.F., and Lee F.S. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc. Natl. Acad. Sci. USA 103 (2006) 654-659
39. Pescador N., Cuevas Y., Naranjo S., Alcaide M., Villar D., Landázuri M.O., and Del Peso L. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem. J. 390 (2005) 189-197
40. Salnikow K., Donald S.P., Bruick R.K., Zhitkovich A., Phang J.M., and Kasprzak K.S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J. Biol. Chem. 279 (2004) 40337-40344
41. Schofield C.J., and Ratcliffe P.J. Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol. 5 (2004) 343-354
42. Selak M.A., Armour S.M., MacKenzie E.D., Boulahbel H., Watson D.G., Mansfield K.D., Pan Y., Simon M.C., Thompson C.B., and Gottlieb E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7 (2005) 77-85
43. Stiehl D.P., Wirthner R., Köditz J., Spielmann P., Camenisch G., and Wenger R.H. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J. Biol. Chem. 281 (2006) 23482-23491
44. Takeda K., Ho V., Takeda H., Duan L.J., Nagy A., and Fong G.H. Placental but not heart defect is associated with elevated HIFα levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol. 26 (2006) 8336-8346
45. To K.K., and Huang L.E. Suppression of hypoxia-inducible factor 1α (HIF-1α) transcriptional activity by the HIF prolyl hydroxylase EGLN1. J. Biol. Chem. 280 (2005) 38102-38107
46. Wenger R.H. Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 203 (2000) 1253-1263
47. 2-regulated gene expression. FASEB J. 16 (2002) 1151-1162
48. Wenger R.H. Mitochondria: Oxygen sinks rather than sensors?. Med. Hypotheses 66 (2006) 380-383
49. Wenger R.H., Stiehl D.P., and Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci. STKE 2005 (2005) re12
50. Willam C., Maxwell P.H., Nichols L., Lygate C., Tian Y.M., Bernhardt W., Wiesener M., Ratcliffe P.J., Eckardt K.U., and Pugh C.W. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J. Mol. Cell. Cardiol. 41 (2006) 68-77