A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 3, 2006, Pages 654-659

  Percy, Melanie J ^a   Zhao, Quan ^b   Flores, Adrian ^b   Harrison, Claire ^c   Lappin, Terence R J ^d   Maxwell, Patrick H ^e   McMullin, Mary Frances ^d   Lee, Frank S ^b  

^a BELFAST CITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

EGLN1; Epo; Hypoxia inducible factor; Proteasome; VHL

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; PROTEASOME; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ADULT; ANEMIA; ANGIOGENESIS; ARTICLE; CASE REPORT; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ERYTHROCYTOSIS; FAMILIAL DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; HOMEOSTASIS; HUMAN; HYDROXYLATION; MALE; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ADULT; AMINO ACID SUBSTITUTION; CELL LINE; FEMALE; HOMEOSTASIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; MALE; MIDDLE AGED; OXYGEN; POINT MUTATION; POLYCYTHEMIA; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA;

EID: 31444436640     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508423103     Document Type: Article

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