Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 40337-40344

  Salnikow, Konstantin ^a   Donald, Steven P ^a   Bruick, Richard K ^b   Zhitkovich, Anatoly ^c   Phang, James M ^a   Kasprzak, Kazimierz S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARCINOGENS; CHEMICAL ACTIVATION; COBALT; ENZYMES; GENES; HYDROXYLATION; IRON; NICKEL; OXYGEN;

CARCINOGENIC COMPOUNDS; HYDROXYLASES; HYPOXIA-INDUCIBLE GENES; INTRACELLULAR ASCORBATE;

CELLS;

2 OXOGLUTARIC ACID; AMINO ACID; ASCORBIC ACID; CARCINOGEN; COBALT; COMPLEMENTARY DNA; HEAVY METAL; HYPOXIA INDUCIBLE FACTOR 1; NICKEL; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CARCINOGENICITY; CELL CULTURE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INACTIVATION; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; HYPOXIA; LUNG CANCER; LUNG INJURY; MALIGNANT TRANSFORMATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REPORTER GENE; VITAMIN BLOOD LEVEL; WESTERN BLOTTING;

ANOXIA; ASCORBIC ACID; BLOTTING, WESTERN; CARCINOGENS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COBALT; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; KETOGLUTARIC ACIDS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; MUTATION; NICKEL; NUCLEAR PROTEINS; OXYGEN; PLASMIDS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROLINE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 4644260710     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403057200     Document Type: Article

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