Suppression of hypoxia-inducible factor 1α (HIF-1α) transcriptional activity by the HIF prolyl hydroxylase EGLN1

Journal of Biological Chemistry

Volumn 280, Issue 45, 2005, Pages 38102-38107

  To, Kenneth K W ^a   Huang, L Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; GENES; HYDROXYLATION; PHARMACOKINETICS; PROTEINS; TUMORS;

HYPOXIA; NEGATIVE FEEDBACK MECHANISM; TARGET GENE EXPRESSION; TRANSCRIPTION FACTORS;

ENZYMES;

ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; PROLYL HYDROXYLASE EGLN1; PROLYL HYDROXYLASE EGLN2; PROLYL HYDROXYLASE EGLN3; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; EGLN1 GENE; EGLN2 GENE; EGLN3 GENE; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROXYLATION; ISCHEMIA; MAMMAL; MOLECULAR RECOGNITION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; GENE SILENCING; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 27844577728     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504342200     Document Type: Article

References (51)

1. Wang, G. L., Jiang, B. H., Rue, E. A., and Semenza, G. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5510-5514
2. Bunn, H. F., and Poyton, R. O. (1996) Physiol. Rev. 76, 839-885
3. Semenza, G. L. (1999) Annu. Rev. Cell Dev. Biol. 15, 551-578
4. Wenger, R. H. (2002) FASEB J. 16, 1151-1162
5. Giaccia, A., Siim, B. G., and Johnson, R. S. (2003) Nat. Rev. Drug Discov. 2, 803-811
6. Huang, L. E., and Bunn, H. F. (2003) J. Biol. Chem. 278, 19575-19578
7. Pugh, C. W., and Ratcliffe, P. J. (2003) Nat. Med. 9, 677-684
8. Poellinger, L., and Johnson, R. S. (2004) Curr. Opin. Genet. Dev. 14, 81-85
9. Semenza, G. L. (2003) Nat. Rev. Cancer 3, 721-732
10. Koshiji, M., Kageyama, Y., Pete, E. A., Horikawa, I., Barrett, J. C., and Huang, L. E. (2004) EMBO J. 23, 1949-1956
11. Koshiji, M., and Huang, L. E. (2004) Cell Cycle 3, 853-854
12. Koshiji, M., To, K. K., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., and Huang, L. E. (2005) Mol. Cell 17, 793-803
13. Wang, G. L., and Semenza, G. L. (1995) J. Biol. Chem. 270, 1230-1237
14. Arany, Z., Huang, L. E., Eckner, R., Bhattacharya, S., Jiang, C., Goldberg, M. A., Bunn, H. F., and Livingston, D. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12969-12973
15. Bhattacharya, S., Michels, C. L., Leung, M. K., Arany, Z. P., Kung, A. L., and Livingston, D. M. (1999) Genes Dev. 13, 64-75
16. Kallio, P. J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H., and Poellinger, L. (1998) EMBO J. 17, 6573-6586
17. Wang, G. L., and Semenza, G. L. (1993) J. Biol. Chem. 268, 21513-21518
18. Huang, L. E., Arany, Z., Livingston, D. M., and Bunn, H. F. (1996) J. Biol. Chem. 271, 32253-32259
19. Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M., and Ratcliffe, P. J. (1997) J. Biol. Chem. 272, 11205-11214
20. Salceda, S., and Caro, J. (1997) J. Biol. Chem. 272, 22642-22647
21. Huang, L. E., Gu, J., Schau, M., and Bunn, H. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7987-7992
22. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G., Jr. (2001) Science 292, 464-468
23. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
24. Yu, F., White, S. B., Zhao, Q., and Lee, F. S. (2001) Proc. Natl. Acad. Scei. U. S. A. 98, 9630-9635
25. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) Nature 399, 271-275
26. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. (2000) Nat. Cell Biol. 2, 423-427
27. Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R. C., and Conaway, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10430-10435
28. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) J. Biol. Chem. 275, 25733-25741
29. Tanimoto, K., Makino, Y., Pereira, T., and Poellinger, L. (2000) EMBO J. 19, 4298-4309
30. Taylor, M. S. (2001) Gene (Amst.) 275, 125-132
31. Epstein, A. C., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., Tian, Y. M., Masson, N., Hamilton, D. L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P. H., Pugh, C. W., Schofield, C. J., and Ratcliffe, P. J. (2001) Cell 107, 43-54
32. Bruick, R. K., and McKnight, S. L. (2001) Science 294, 1337-1340
33. Mahon, P. C., Hirota, K., and Semenza, G. L. (2001) Genes Dev. 15, 2675-2686
34. Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., and Whitelaw, M. L. (2002) Science 295, 858-861
35. Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., and Bruick, R. K. (2002) Genes Dev. 16, 1466-1471
36. Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y. M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., Ratcliffe, P. J., Pugh, C. W., and Schofield, C. J. (2002) J. Biol. Chem. 277, 26351-26355
37. Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J., and Schofield, C. J. (2003) J. Biol. Chem. 278, 1802-1806
38. Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Burgel, T., Jelkmann, W., Acker, H., and Fandrey, J. (2003) J. Cell Sci. 116, 1319-1326
39. del Peso, L., Castellanos, M. C., Ternes, E., Martin-Puig, S., Cuevas, Y., Olmos, G., and Landazuri, M. O. (2003) J. Biol. Chem. 278, 48690-48695
40. Berra, E., Benizri, E., Ginouves, A., Volmat, V., Roux, D., and Pouyssegur, J. (2003) EMBO J. 22, 4082-4090
41. Elbashir, S. M., Harborth, J., Weber, K., and Tuschl, T. (2002) Methods 26, 199-213
42. Gu, J., Milligan, J., and Huang, L. E. (2001) J. Biol. Chem. 276, 3550-3554
43. Huang, L. E., Pete, E. A., Schau, M., Milligan, J., and Gu, J. (2002) J. Biol. Chem. 277, 41750-41755
44. Kageyama, Y., Koshiji, M., To, K. K., Tian, Y. M., Ratcliffe, P. J., and Huang, L. E. (2004) FASEB J. 18, 1028-1030
45. Jiang, B. H., Rue, E., Wang, G. L., Roe, R., and Semenza, G. L. (1996) J. Biol. Chem. 271, 17771-17778
46. Isaacs, I. S., Jung, Y. J., Mimnaugh, E.G., Martinez, A., Cuttitta, F., and Neckers, L. M. (2002) J. Biol. Chem. 277, 29936-29944
47. Appelhoff, R. J., Tian, Y. M., Raval, R. R., Turley, H., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., and Gleadle, J. M. (2004) J. Biol. Chem. 279, 38458-38465
48. Berra, E., Richard, D. E., Gothie, E., and Pouyssegur, J. (2001) FEBS Lett. 491, 85-90
49. Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Glaccia, A. J., and Semenza, G. L. (2005) Mol. Cell 17, 503-512
50. Ozer, A., Wu, L. C., and Bruick, R. K. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 7481-7486
51. Hewitson, K. S., and Schofield, C. J. (2004) Drug Discov. Today 9, 704-711