Stability of bovine serum albumin complexed with PEG-poly(L-histidine) diblock copolymer in PLGA microspheres

Journal of Controlled Release

Volumn 109, Issue 1-3, 2005, Pages 86-100

  Kim, Jong Ho ^a,b   Taluja, Ajay ^a   Knutson, Kristine ^a   Han Bae, You ^a  

^a UNIVERSITY OF UTAH   (United States)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Acidic microenvironment; Buffering capacity; PEG poly(histidine) diblock copolymer; Poly(lactic co glycolic acid) PLGA ; Protein stability

Indexed keywords

BIODEGRADATION; BLOCK COPOLYMERS; COMPLEXATION; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; PH EFFECTS; POLYETHYLENE GLYCOLS; SOLUTIONS; SPECTROPHOTOMETRY; ULTRAVIOLET SPECTROSCOPY;

ACIDIC MICROENVIRONMENT; BUFFERING CAPACITY; PEG-POLY(L-HISTIDINE) DIBLOCK COPOLYMERS; POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA); PROTEIN STABILITY;

PROTEINS;

BOVINE SERUM ALBUMIN; COPOLYMER; EXCIPIENT; MICROSPHERE; POLY(ETHYLENE GLYCOL)POLY(HISTIDINE)DIBLOCK COPOLYMER; POLYGLACTIN; POLYHISTIDINE; UNCLASSIFIED DRUG;

ACIDITY; AQUEOUS SOLUTION; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFERENCE PAPER; CONFOCAL MICROSCOPY; DEGRADATION KINETICS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EMULSION; FLUORESCENCE ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STABILITY; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

DRUG STABILITY; EXCIPIENTS; HISTIDINE; HYDROGEN-ION CONCENTRATION; KINETICS; LACTIC ACID; MICROSCOPY, CONFOCAL; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SERUM ALBUMIN, BOVINE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 28444435109     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.09.016     Document Type: Conference Paper

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